Total number of articles (from all journals) and average impact factor (averaged from all journals) from 2002–2010.

<p>Total number of articles (from all journals) and average impact factor (averaged from all journals) from 2002–2010.</p

Effect of VPA on tumor volume in Caki-1 xenografts in mice.

<p>Mice in the treatment arm received 200 mg VPA/kg once daily. Control mice received solvent (n = 6). *indicates significant difference to the control mice.</p

Correlation of impact factor (IF) 2002–2010 with percentage of articles in each category (clinical, experimental, review and commentarial).

<p>n.s. = not significant, r = regression, p indicates significance value.</p

Western Blot analysis of cell cycle regulating (fig. 2A) and cell signaling proteins (fig. 2B) in tumor tissue from drug-sensitive (responders) versus drug-resistant mice (non-responders).

<p>Control tissue specimens were taken from untreated animals. Cell lysates (50 µg) were subjected to SDS-PAGE and blotted on the membrane incubated with the corresponding monoclonal antibodies. β-actin served as the internal control. The figure shows one representative from three separate experiments.</p

Long-term exposure of VPA causes drug resistance and Akt up-regulation.

<p><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053100#pone-0053100-g004" target="_blank">Fig. 4A</a>: Caki-1 cells were treated for 2 weeks (short-term) or 12 weeks (long-term) with 1 mM VPA, and cell growth was analysed by the MTT assay. Controls remained untreated. The figure shows one representative from six separate experiments. *indicates significant difference to controls. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0053100#pone-0053100-g004" target="_blank">Fig. 4B</a>: To evaluate Akt expression and activity, Caki-1 cells were treated short-term or long-term with 1 mM VPA. Controls remained untreated. Cell lysates were subjected to SDS-PAGE and blotted on the membrane incubated with the respective monoclonal antibodies. β-actin served as the internal control. One representative from three separate experiments.</p

Percent categorical changes in six urologic journals from 2002–2010.

<p>★ = significant Neumann trend from 2002. # = significant Neumann trend from 2004.</p

Additional file 2: of Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies

Figure S1. Concordance of species coverage predicted by reads (x-axis, both plots) with species coverage predicted by ORFs (y-axis) (bottom) and concordance of total missing ORFs (y-axis) with abundance of species (top) for the Balanced community for each assembler. Both sets of graphs are plotted on natural log vs natural log scales. For regression between coverages, mean values were used—violins of the ORF coverage distributions are shown surrounding each point. (PDF 104 kb

Additional file 1: Table S1. of Utilization of defined microbial communities enables effective evaluation of meta-genomic assemblies

Species abundance in mock staggered community. Table S2. DNA concentration in mock staggered community. Table S3. Tax ID and Accession Numbers for all organisms in mock or synthetic communities. Table S4. MetaQUAST output from mock balanced community. Table S5. metaQUAST output from mock staggered community. (XLSX 84 kb

Meta-analysis (forest plot) of publication effects considering change in impact factor from 2001–2010 and the 95% confidence interval of the ratio of editorship/all publications.

<p>TE = treatment effect, i.e. publication effect. seTe = standard error of treatment effect, i.e. standard error of publication effect. ◊ = overall effect.</p

Additional file 1: Table S1. of Microbial diversity in individuals and their household contacts following typical antibiotic courses

Study subjects. (PDF 275 kb