Dissociable Components of Cognitive Control: An Event-Related Potential (ERP) Study of Response Inhibition and Interference Suppression

Background: Cognitive control refers to the ability to selectively attend and respond to task-relevant events while resisting interference from distracting stimuli or prepotent automatic responses. The current study aimed to determine whether interference suppression and response inhibition are separable component processes of cognitive control. Methodology/Principal Findings: Fourteen young adults completed a hybrid Go/Nogo flanker task and continuous EEG data were recorded concurrently. The incongruous flanker condition (that required interference suppression) elicited a more centrally distributed topography with a later N2 peak than the Nogo condition (that required response inhibition). Conclusions/Significance: These results provide evidence for the dissociability of interference suppression and response inhibition, indicating that taxonomy of inhibition is warranted with the integration of research evidence from neuroscience

The six stimuli used in the present experiment.

<p>The six stimuli used in the present experiment.</p

N2 Amplitude and Latency Summary Statistics (Means, with Standard Deviations in Parentheses).

<p>N2 Amplitude and Latency Summary Statistics (Means, with Standard Deviations in Parentheses).</p

Stimulus-locked ERP waveforms, difference waveforms, and scalp topographic maps.

<p>Left-hand panel: Grand-averaged ERP in response to congruous (blue), incongruous (red), and Nogo (green) stimuli with the amplitude (µV) as the y-axis and time (ms) as the x-axis. Time 0 represents stimulus onset. Middle panel: Grand-averaged difference waveforms computed as the incongruous – congruous waveform (red) and Nogo – congruous (green). Right-hand panel: Topographic distribution of amplitude at the peak latency of the N2 identified in the difference waveforms (incongruous – congruous is shown in the upper map, and Nogo – congruous is shown in the lower map).</p