4 research outputs found
Clinical Efficacy and Tolerability of Praziquantel for Intestinal and Urinary Schistosomiasis—A Meta-analysis of Comparative and Non-comparative Clinical Trials
- Author
- A Danso-Appiah
- A Danso-Appiah
- A Davis
- A Metwally
- AA Massoud
- AA Mohamed
- AB Oyediran
- AH Omer
- AK Al-Aska
- AM Ghandour
- AM Navaratnam
- AT Santos
- B Gryseels
- B Juni
- CH King
- CH Teesdale
- CO Obonyo
- CV Kramer
- CV Kramer
- D De Clercq
- D De Clercq
- D De Clercq
- EK N'Goran
- F Guisse
- FF Stelma
- FW Thiong'o
- G Degu
- G Olds
- G Raso
- GD Burchard
- GL de Rezende
- H Friis
- HA Wilkins
- J Keiser
- J Utzinger
- JC Sousa-Figueiredo
- JE McMahon
- JE McMahon
- JE McMahon
- JE McMahon
- JL Rey
- Julien Zwang
- K Taddese
- LA Tchuente
- LC da Silva
- LC Da Silva
- LC Queiroz
- M El Tayeb
- Malcolm K. Jones
- MC Latham
- MG Chen
- MH Wu
- MM Homeida
- MM Ismail
- MS Sissoko
- MS Sissoko
- MW Kardaman
- MW Kardaman
- N Berhe
- N Katz
- N Midzi
- NB Kabatereine
- P Fernandes
- P Kern
- P Olliaro
- P Steinmann
- P Taylor
- PC Inyang-Etoh
- PE Simonsen
- Piero L. Olliaro
- PL Olliaro
- R Barakat
- R DerSimonian
- RR Abu-Elyazeed
- S Borrmann
- S Botros
- S Knopp
- SJ Pocock
- T Ishizaki
- VY Belizario Jr
- WG Jaoko
- XY Hou
- Z Asfaw
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Parasitic Central Nervous System Infections in Immunocompromised Hosts
- Author
- Anders KH
- Anez N
- Antunes AC
- Bucher HC
- Carr A
- Ching HT
- Conti DJ
- Contreras M
- Cook GC.
- Cordonnier C
- Del Brutto OH
- Del Brutto OH
- Del Brutto OH
- DeVault
- Di Lorenzo GA
- Ferrari ML
- Ferreira MS
- Fowler R
- Gellido CL
- Gomes ML
- Gordillo-Paniagua G
- Gotuzzo E
- Graus F
- Hagensee ME
- Ionita C
- Israelski DM
- Joseph R. Zunt
- Kardaman MW
- Lahn MM
- Lappalainen M
- Leiby DA
- Leiguarda R
- Livramento JA
- Luft BJ
- Luft BJ
- Mahmoud HK
- Malheiros SM
- Martinez HR
- Masdeu JC
- Masur H
- Mauad T
- Mehta J
- Melanie Walker
- Metze K
- Michaels MG
- Nobre V
- Pittella JE
- Pittella JE.
- Porter SB
- Preidler KW
- Rabello AL
- Ramsey RG
- Richards
- Rocha A
- Roghmann MC
- Roman G
- Sanelli PC
- Schad GA
- Silva N
- Slavin MA
- Smallman LA
- Sostak P
- Stuiver PC.
- Takayanagui OM
- Thompson JR
- Thornton CA
- Vazquez MC
- Vishwanath S
- Vyas R
- White
- Publication venue
- 'University of Chicago Press'
- Publication date
- Field of study
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: Results of an international multi-centre study
- Author
- Aaliya A. M.
- Abd Elazeem H. A. S.
- Abdelhafez M. H.
- Abdelmalak A.
- Abdelwahab O. A.
- Abdulhadi O. M. A. S.
- Abdulmalek A.
- Abdulmoiz A.
- Adewole O.
- Ahmed A.
- Ahmed A.
- Aimee L.
- Albatoul M.
- Alexander C.
- Ali A.
- Alice N.
- Alsahab M.
- Avinash A.
- Azzam Y.
- Babar L.
- Babb L.
- Badh M.
- Baguiasri M.
- Baguneid C.
- Bailey E.
- Baili E.
- Baldwin S.
- Baloyiannis I.
- Bannerjee M.
- Barnard A.
- Barra F.
- Bashir H.
- Bawor M.
- Bayhan Z.
- Beishon L.
- Belcher J.
- Belgamwar R.
- Bentley C.
- Birchenough A.
- Boden R.
- Bouhuwaish A.
- Brachini G.
- Bremner L.
- Bridgwater H.
- Brown B.
- Bryant C.
- Budd G.
- Budd S.
- Budzikoski A.
- Bulla R.
- Buondonno A.
- Burden N.
- Burn E.
- Burton J. K.
- Butt H.
- Capoglu R.
- Caracostea A.
- Cardoso R.
- Carolyn A.
- Carr A.
- Carrasco-Prats M.
- Catherine A.
- Catherine O.
- Cattel C.
- Ceccarelli G.
- Cecere G.
- Charalabopoulos A.
- Charsley E.
- Cheney-Lowe H.
- Cheran A.
- Chevallier T.
- Choudhry A. J.
- Christina O.
- Ciccarone F.
- Cicerchia P. M.
- Cirillo B.
- Collins F. D.
- Comerford V.
- Cordie A.
- Coulter S.
- Coulthard N.
- Cox C.
- Cox N.
- Cox V.
- Crowe A.
- Cullen J.
- Cummings J.
- Cunningham N.
- Curley D.
- Currie H.
- Daly M.
- Dani M.
- Danielle L.
- Darley J.
- Dattani N.
- Davakis S.
- Davies R.
- De Paola G.
- De Toma G.
- Del Valle-Ruiz S.
- Deldar B.
- Demir H.
- Desai A.
- Desai N.
- Devaney A.
- Dew L.
- Dhesi J.
- Dias M.
- Dick G.
- Doddamani P.
- Dogra G.
- Doll T.
- Dooley H. C.
- Dost S.
- Dotchin C.
- Dowell H.
- Drghita I. M.
- Dundas J. M.
- Duranti G.
- Dusara H.
- Dwivedi R.
- Dyer A. H.
- Eastaugh A.
- Edwards E.
- Eirene Y.
- El-Shazly M.
- Elabedeen O. Z.
- Eleanor L.
- Elghazaly S. M.
- Elhadi M.
- Elmehrath A. O.
- Elrick H.
- Elsayed A.
- Eltayeb M. A.
- Emery A.
- Emily L.
- Emma L.
- Emrah A.
- Etchill E. W.
- Evans S.
- Evison F.
- Fairhead C.
- Fatih A. -S.
- Faulkner M.
- Favour N.
- Felska A.
- Fernandez A.
- Fernandez-Fernandez P. V.
- Ferraiolo A.
- Ferrero S.
- Fiori E.
- First N.
- Fisk G.
- Fleck A.
- Francesco A.
- Freshwater S.
- Gabre-Kidan F. A.
- Gabriel L.
- Gallo G.
- Gandhi R.
- Garner M.
- Gaunt V.
- Gavriella L.
- Georgiou N.
- Gerretsen H.
- Ghannam N. A. A.
- Ghobrial A.
- Ghobrial H.
- Ghufoor Z.
- Gibbon J.
- Gilbert G. F.
- Giles M.
- Gimenez-Frances C.
- Giovanni B.
- Gitanjali A.
- Gonullu E.
- Gordon A.
- Goujon M.
- Grace L.
- Gray A.
- Gray J. H.
- Green D.
- Greene C.
- Griffin E.
- Griffith K.
- Grubb A.
- Guan Y.
- Guerero D. N.
- Gupta A.
- Gustavino C.
- Guzman L.
- Hadreiez A. K. M.
- Hajiioannou J.
- Hale M.
- Hanji D.
- Harmantepe T.
- Harrison P.
- Harsha M.
- Hart B.
- Haslam A.
- Haunton V.
- Haut E. R.
- Hayley J. B.
- Hazem A. A.
- Heinsohn T.
- Helena L.
- Hennah L.
- Hetta H. F.
- Hickman A.
- Hobill A.
- Hogan P. C. P.
- Hogan V.
- Holmes E.
- Honney K.
- Hood K.
- Hopkinson K.
- Howells L.
- Hrouda N.
- Hughes T.
- Hunsley D.
- Hurst W.
- Hussein A. R. M.
- Ibrahim E. A. A.
- Ibtida I.
- Ibukunoluwakitan A.
- Ishlek I.
- Islam A.
- Ismini P.
- Iyer R.
- Jackson K.
- Jackson R.
- Jackson T. A.
- Jade M.
- James E.
- Jarita V. S.
- Jarvis H.
- Jeffs S.
- Jelley B.
- Jenko N.
- Jessica P.
- Jeyakumar S.
- Jocelyn A.
- Jolene A.
- Kabir S.
- Kainth H.
- Kalloo J.
- Kanzaria A.
- Karapanou A.
- Kardaman N.
- Karthikeyan S.
- Karunatilleke A.
- Kelly M.
- Kelly N. I.
- Khalid H.
- Khan A.
- Khan H.
- Khan M. S.
- Khiroya H.
- King M.
- Kingsley H. A.
- Kneen T.
- Kok L.
- Kratochwila C.
- Kuzeva A.
- Lal R.
- Lapolla P.
- Lau R.
- Laura W.
- Lauren P.
- Lelt Y.
- Lia O.
- Lily L. -M.
- Lobna A. -S.
- Lochlainn M. N.
- Luigi S.
- Madden K.
- Madhavan D. H.
- Magill L.
- Manning H.
- Mantoglu B.
- Marc O.
- Martinez-Sanz N.
- Marx W.
- Masoli J.
- Masood A. E.
- Masud T.
- Maughan T.
- Mawhinney J.
- Maxfield D.
- Mayer J.
- Maynard H.
- Mccluskey L.
- Mcdonald C.
- Mcgovern A.
- Mclachlan S.
- Mcneela N.
- Medina-Manuel E.
- Meneghini S.
- Merve Y.
- Metcalf M.
- Millwood-Hargrave J.
- Mingoli A.
- Miu K.
- Mohamed Aliae S. M.
- Mohamed F.
- Mohamed H.
- Mohammad A. A.
- Mohammed A.
- Mohammed M. A.
- Mohammedseid-Nurhussien A.
- Momen M. A. A.
- Moomo F.
- Moorey H.
- Mora-Guzman I.
- Moriarty L.
- Morrin H.
- Morris C.
- Moss N.
- Moustafa M. M.
- Mpoura M.
- Mubin M.
- Muhammed A.
- Muhtaroglu A.
- Muir G.
- Mulhern S.
- Muller D.
- Murphy D. C.
- Muzammil B.
- Nadkarni V.
- Nasreldin K.
- Natalie W.
- Nawaz W.
- Nee Y.
- Nguyen H.
- Ni C.
- Nikolaos S.
- Nirantharakumar K.
- Okoth K.
- Olebu O.
- Omoteniola O.
- Osuafor C. N.
- Passby C.
- Pastor-Perez P.
- Patel H.
- Patel S.
- Patterson K.
- Pearson G. M. E.
- Pedro L.
- Penfold R.
- Perinpanathan R.
- Perivoliotis K.
- Perra T.
- Perry R.
- Pettitt M.
- Pigott J.
- Pinkney M.
- Pinkney T.
- Pinotti E.
- Porcu A.
- Price A.
- Pugliese F.
- Puri P.
- Pytraczy S.
- Qaiser Y.
- Quinn T.
- Qurashi M.
- Rachael A.
- Radenkovic D.
- Rajeswaran T.
- Rand A.
- Rapaport S. F.
- Razzak T.
- Rebecca W.
- Reilly L.
- Reynolds A.
- Reynolds P.
- Richardson A.
- Richardson S.
- Roberts A.
- Roberts-Rhodes C.
- Robinson T.
- Rocca A.
- Ross-Skinner E.
- Ruiz-Marin M.
- Ryall R.
- Saad A. M.
- Saad M. M.
- Sadiq A.
- Sally T. A.
- Sammarco G.
- Sampanis M. A.
- Samuel N.
- Sanghvi H.
- Sanyal N.
- Sapienza P.
- Sarah M.
- Sayers R.
- Scott L.
- Seed A.
- Sen M.
- Shaban M. A. A.
- Shakespeare K. T.
- Shaw E.
- Shaw H.
- Sheldrake J.
- Shivam P.
- Sinead O.
- Sivarajan S. S.
- Sleeman I.
- Smith J.
- Soo C.
- Speranza F.
- Spice C.
- Stafford A.
- Stambollouian K.
- Stephanie W.
- Stephen L.
- Stevens K. A.
- Steves C.
- Stewart J.
- Strain W. D.
- Stratton E.
- Street H.
- Surtees M.
- Suvira L.
- Swinnerton E.
- Sylvia A.
- Taha A.
- Taher A. S. A.
- Tait C.
- Taylor A.
- Taylor J.
- Thake M.
- Theodore L.
- Thin K.
- Thould H.
- Thyn T.
- To B.
- Tobiss H.
- Toppley K.
- Torsney K.
- Townsend L.
- Tullo E.
- Tzovaras G.
- Umeadi A.
- Vaidya H.
- Valero-Soriano M.
- Varden R.
- Vergani V.
- Vervoort D.
- Vescio G.
- Vettasseri M.
- Virk M.
- Vyas V.
- Wagland J.
- Wallis S.
- Warner C.
- Watkins E.
- Watson H.
- Webb R.
- Welch C.
- Welsh S. H.
- West R.
- Whelan E.
- Whitney J.
- Whitsey M.
- Wilcock C.
- Wilkinson I.
- Williams D.
- Williamson M.
- Willott R. H.
- Wilson D.
- Wimalasundera M.
- Witham M.
- Yang S.
- Yasin Y.
- Yasmin N.
- Yee K.
- Yesim M. A.
- Yildiz A.
- Yusuf H.
- Zambon M.
- Zaw H.
- Zeinab M.
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2021
- Field of study
Age and frailty are independently associated with increased COVID-19 mortality and increased care needs in survivors: results of an international multi-centre study
- Author
- Aaliya Mohammed (12499327)
- Abdulkader Mohammad (12499324)
- Abdulmalek Aljafari (12498697)
- Abdulmoiz Aljafari (12498700)
- Abigail Hobill (12499126)
- Abigail Reynolds (9119102)
- Adam Budzikoski (12498805)
- Adam Gordon (825422)
- Adam H Dyer (12498967)
- Adam Seed (2367799)
- Agnieszka Felska (12499003)
- Ahmad Bouhuwaish (9757988)
- Ahmed A Momen (12499330)
- Ahmed Cordie (12498865)
- Ahmed KM Hadreiez (12499093)
- Ahmed O Elmehrath (12498979)
- Ahmed SA Taher (12499558)
- Ahmed Y Azzam (12229460)
- Aidan Haslam (12499108)
- Aimee Leadbetter (12499234)
- Aina Ibukunoluwakitan (12499159)
- Aine McGovern (10174331)
- Akhil Kanzaria (12499198)
- Alberto Porcu (5473763)
- Aldo Rocca (10650326)
- Alexander Emery (12498988)
- Alexander Hickman (12499123)
- Alexander Noar (12499387)
- Alexandra Richardson (12499465)
- Alexandros Charalabopoulos (12498838)
- Alexis Carr (12498829)
- Ali Ali (3510386)
- Ali Muhtaroglu (12499357)
- Aliae AR Mohamed Hussein (12499321)
- Alice Devaney (12498922)
- Alice O'Docherty (12499393)
- Alison Eastaugh (12498970)
- Almontacer EB Masood (12499279)
- Alodia Gabre-Kidan (12499027)
- Alshaimaa M Saad (12499483)
- Amalia Karapanou (12499201)
- Amanda Stafford (12499537)
- Ambreen Sadiq (12499489)
- Amelia Roberts (12499468)
- Amir Abdelmalak (12498673)
- Amy Birchenough (12498781)
- Amy Gray (4541533)
- Amybel Taylor (12499564)
- Andra Caracostea (12498823)
- Andrea Mingoli (11397024)
- Andrew Crowe (450839)
- Andrew Ghobrial (12499045)
- Aneliya Kuzeva (12499228)
- Angeline Price (10174343)
- Anna Barnard (1987999)
- Anna Fleck (12499021)
- Anne Karunatilleke (12499210)
- Anthony Grubb (12499081)
- Anthony Umeadi (12499591)
- Antia Fernandez (12499006)
- Antonella Ferraiolo (696685)
- Antonio Buondonno (12498811)
- Arjun Desai (12498919)
- Asad J Choudhry (12498850)
- Asma Khan (8140407)
- Avinash Aujayeb (12229442)
- Awolkhier Mohammedseid-Nurhussien (12498631)
- Ayushi Gupta (9031847)
- Baguiasri Mandane (12499264)
- Barbara Hart (12499105)
- Baris Mantoglu (12499270)
- Benjaman To (12499579)
- Benjamin Jelley (12498613)
- Benyamin Deldar (12498916)
- Bruno Cirillo (9503960)
- Bryony Brown (12498586)
- Bushra Muzammil (12499369)
- Carly Welch (6206861)
- Caroline Tait (12499561)
- Carolyn Akladious (12498694)
- Cassandra Fairhead (12498997)
- Caterina Cattel (12498835)
- Catherine Atkin (12498733)
- Catherine Bryant (5072462)
- Catherine Dotchin (5983973)
- Catherine O'Mahony (12499405)
- Catherine Wilcock (12499639)
- Catrin Cox (12498874)
- Charlotte Greene (12499072)
- Charlotte Roberts-Rhodes (12499471)
- Chee Soo (12498658)
- Cheran Anandarajah (12498721)
- Chiara Kratochwila (12499225)
- Chloe Warner (12499618)
- Christina Page (12499414)
- Christopher N Osuafor (12498634)
- Claire McDonald (627409)
- Claire Morris (2019940)
- Claire Spice (12499534)
- Claire Steves (5144204)
- Clara Gimenez-Frances (12499063)
- Clare Baguneid (12498754)
- Claudio Gustavino (12499087)
- Cliona Ni Cheallaigh (9617430)
- Corrina Bentley (12498778)
- Daisy Wilson (6011324)
- Daniel Curley (12498886)
- Daniel Muller (3244128)
- Daniel N Guerero (12499084)
- Danielle Hunsley (12499150)
- Danielle Lis (12499240)
- David Williams (229939)
- Declan C Murphy (12499366)
- Deepthy Hari Madhavan (12499102)
- Deevia Hanji (12499099)
- Deirdre Green (12499069)
- Dina Radenkovic (4676860)
- Dominic Maxfield (12499288)
- Dominique Vervoort (8468494)
- Efstratia Baili (12258342)
- Eirene Yeung (210321)
- Eleanor Lunt (12499252)
- Eleanor Watkins (12499621)
- Elinor Burn (12498589)
- Elinor Edwards (12498973)
- Elisha Whelan (12499630)
- Elizabeth Holmes (12499135)
- Ellanna Griffin (12499075)
- Ellen James (12499174)
- Ellen Tullo (2880158)
- Ellie Shaw (12499513)
- Elliott R Haut (12499111)
- Elsayed M Awad (12498736)
- Eltayeb A Ahmed (12498685)
- Emily Bailey (5754929)
- Emily Lyon (12499255)
- Emily Ross-Skinner (12499474)
- Emma Livesey (12499243)
- Emma Stratton (12499546)
- Emma Swinnerton (12499555)
- Emre Gonullu (12258426)
- Enrico Fiori (12499012)
- Enrico Pinotti (12499438)
- Eric W Etchill (12498991)
- Esther Medina-Manuel (12499300)
- Evelyn Charsley (12498841)
- Fabio Barra (12229463)
- Fabio Speranza (3594422)
- Farhana Moomo (12499333)
- Fatih Altintoprak (12467228)
- Fatma D Collins (12498859)
- Favour Nwolu (12499390)
- Fawsiya Mohamed (12499315)
- Felicity Evison (12498994)
- Flavia Ciccarone (12498853)
- Francesco Alessandri (6787682)
- Francesco Pugliese (792375)
- Gabriel Lee (838259)
- Gabrielle Budd (12498799)
- Gaetano Gallo (6173327)
- Gavriella Levinson (12499237)
- George Tzovaras (12499588)
- Georgia F Gilbert (12499057)
- Georgina Muir (12499360)
- Giancarlo Ceccarelli (648611)
- Gilda De Paola (12498907)
- Gioia Brachini (12498790)
- Giorgio De Toma (12498910)
- Giovanni B Fonsi (12499024)
- Gitanjali Amaratungaz (12498709)
- Giulia Duranti (12498958)
- Giuseppe Cecere (1928059)
- Giuseppe Sammarco (575750)
- Giuseppina Vescio (12499600)
- Gordon Dick (12498934)
- Grace Lewis (6813344)
- Grace ME Pearson (12498640)
- Gracie Fisk (12499018)
- Gurinder Dogra (12498940)
- Hakan Demir (1454902)
- Hamilton Morrin (12499342)
- Hanna Nguyen (12499384)
- Hannah Bashir (12498766)
- Hannah Bridgwater (12498796)
- Hannah C Dooley (8214468)
- Hannah Cheney-Lowe (12498844)
- Hannah Currie (12498889)
- Hannah Dowell (12498949)
- Hannah Gerretsen (12499039)
- Hannah Moorey (3548264)
- Hannah Shaw (12499516)
- Hannah Street (12499549)
- Hannah Thould (12499573)
- Hannah Tobiss (12499582)
- Hannah Watson (71406)
- Haris Khan (8748504)
- Harjinder Kainth (12499192)
- Harnish Patel (3532901)
- Harsha Malapati (11091047)
- Hayley Jarvis (12499177)
- Hayley R Boden (12498787)
- Hazel Sanghvi (12499495)
- Hazem Ahmed (2734090)
- Hedra Ghobrial (12499048)
- Heena Khiroya (12498616)
- Hein Zaw (5772269)
- Hejab Butt (12498817)
- Helal F Hetta (12499120)
- Helena Lee (7481552)
- Henry Maynard (12499294)
- Hesham Khalid (12499213)
- Hiren Dusara (12498961)
- Hope Elrick (12498982)
- Hossam Aldein S Abd Elazeem (12498667)
- Hrisheekesh Vaidya (4241539)
- Humza Yusuf (12499666)
- Iain Wilkinson (11210310)
- Ioan M Draghita (12498952)
- Ioannis Baloyiannis (12498760)
- Irem Ishlek (12499162)
- Ishmam Ibtida (9849214)
- Islam A Ahmed (12498688)
- Ismael Mora-Guzman (12499336)
- Ismini Panayotidis (4778079)
- Isobel Sleeman (12498655)
- Jack Cullen (12498877)
- Jack Stewart (11781983)
- Jade Man (12499261)
- Jake Gibbon (12499054)
- James Belcher (12498772)
- James M Dundas (12498955)
- Jamie Mawhinney (12499285)
- Jane Masoli (3540020)
- Jarita Sivam (12499528)
- Jason Kalloo (12499195)
- Jay Darley (12498895)
- Jean Cummings (12498880)
- Jenni K Burton (12498592)
- Jennifer Pigott (12498649)
- Jennifer Smith (172056)
- Jessica Parkin (12499420)
- Jiannis Hajiioannou (12499096)
- Joanne Taylor (49271)
- Joanne Wagland (12499612)
- Jocelyn Amer (12498712)
- John Millwood-Hargrave (12499309)
- Jolene Atia (3172896)
- Jonathan Sheldrake (12499519)
- Jordan Mayer (12499291)
- Joshua H Gray (12499066)
- Jugdeep Dhesi (12498928)
- Julie Whitney (12499633)
- Kar Yee Law (12499231)
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- Melanie Dani (6397982)
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- Mohammed Ahmad (9120880)
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- Monica Bawor (516749)
- Mosab AA Shaban (12499507)
- Mostafa El-Shazly (12498985)
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- Mustafa Alsahab (12498583)
- Natalie Cox (12498595)
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- Parveen Doddamani (12498937)
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- W David Strain (12498661)
- Wasim Nawaz (12499381)
- William Hurst (4229008)
- William Marx (12499276)
- Yasin A Yildiz (12499663)
- Yasmin K NasrEldin (12499378)
- Yen Nee J Bo (12498784)
- Yu Lelt Win (12499648)
- Yue Guan (2178228)
- Yusra Qaiser (12499447)
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- Zeinab Majid (9957176)
- Zulfu Bayhan (12498769)
- Publication venue
- Publication date
- 05/02/2021
- Field of study
Introduction: Increased mortality has been demonstrated in older adults with coronavirus disease 2019 (COVID-19), but the effect of frailty has been unclear.
Methods: This multi-centre cohort study involved patients aged 18 years and older hospitalised with COVID-19, using routinely collected data. We used Cox regression analysis to assess the impact of age, frailty and delirium on the risk of inpatient mortality, adjusting for sex, illness severity, inflammation and co-morbidities. We used ordinal logistic regression analysis to assess the impact of age, Clinical Frailty Scale (CFS) and delirium on risk of increased care requirements on discharge, adjusting for the same variables.
Results: Data from 5,711 patients from 55 hospitals in 12 countries were included (median age 74, interquartile range [IQR] 54–83; 55.2% male). The risk of death increased independently with increasing age (>80 versus 18–49: hazard ratio [HR] 3.57, confidence interval [CI] 2.54–5.02), frailty (CFS 8 versus 1–3: HR 3.03, CI 2.29–4.00) inflammation, renal disease, cardiovascular disease and cancer, but not delirium. Age, frailty (CFS 7 versus 1–3: odds ratio 7.00, CI 5.27–9.32), delirium, dementia and mental health diagnoses were all associated with increased risk of higher care needs on discharge. The likelihood of adverse outcomes increased across all grades of CFS from 4 to 9.
Conclusion: Age and frailty are independently associated with adverse outcomes in COVID-19. Risk of increased care needs was also increased in survivors of COVID-19 with frailty or older age.</p