Osteogenesis imperfecta and attention deficit hyperactivity disorder: A rare combination

Osteogenesis Imperfecta (OI) is a rare, autosomally inherited disorder of the connective tissue matrix that is characterized by bone fractures, deafness, and blue sclera. The impairment of Type 1 collagen production causes frequent fractures and increased bone fragility as well as reduced bone mass. Attention Deficit Hyperactivity Disorder (ADHD) is a chronic neurobehavioral disorder developed during childhood that is characterized by inattention, hyperactivity, impulsivity and, consequently, high risk for unintentional injury. This study will examine the case of a 6-year-old male admitted to the researchers clinic who has been diagnosed with OI and ADHD and has experienced reccurent traumatic injury. While in the clinic, the patient also expressed symptoms of anxiety such as insomnia, restlessness and irritability. This case has beenpresented since associations of both d,sorder is rare. Aside from the fact that these disorders are injury-related and, thus, require additional attention by clinicians, the simultaneous nature of these diseases is also important in that their interaction may provide opportunity for early diagnosis and necessary intervention. [Med-Science 2018; 7(1.000): 232-234

Pre- and postoperative quality of life and emotional/behavioural problems in children with PFAPA

Objective: This study aimed to evaluate the effects of surgical intervention on quality of life, emotional/behavioural problems and school absenteeism in children with periodic fever, aphthous stomatitis, pharyngitis and cervical adenitis (PFAPA.

Sertraline-Induced Amotivationel Syndrome in a 12-Year-Old Girl: A Case Report

Sertraline is a safe and effective agent frequently used in the treatment of childhood depression and obsessive compulsive disorder. Amotivational syndrome is also an important clinical manifestation characterized by decreased capacity to make and carry out long-term plans and lack of motivation. This report describes the development of amotivational syndrome in a 12-year-old girl receiving sertraline monotherapy and successful management of this side effect with discontinuation of sertraline and initiation of fluoxetine therapy. This case is presented because, to the best of our knowledge, there have been very few case reports regarding the development of sertraline-related amotivational syndrome and, more importantly, because of the very low number of case reports in which amotivational syndrome was managed by switching to a different selective serotonin reuptake inhibitor

ARID1B gene mutation in a patient with Coffin-Siris syndrome and Autism Spectrum Disorder

Various factors may contribute to the emergence of Autism Spectrum Disorder (ASD). Genetic factors are particularly prominent in the etiology of ASD, and genetic syndromes may frequently accompany the disorder. Coffin-Siris syndrome is a genetic condition characterized by mental retardation, coarse facial appearance, hirsutism/hypertrichosis or skin with sparse hair, distal phalanx aplasia or hypoplasia, and fifth-finger and nail abnormalities. This genetic syndrome is accompanied by numerous different cardiac, genitourinary, gastrointestinal, ophthalmological, and craniofacial systemic abnormalities. ARID1B gene mutation is thought to be involved both in Coffin-Siris syndrome and in the etiology of autism. Although common genetic factors are involved in the etiologies of both diseases, our review of the literature revealed only one case report demonstrating an association between Coffin-Siris syndrome and ASD. This report describes a male patient aged 2 years and 10 months with ARID1B mutation showing Coffin-Siris syndrome and ASD comorbidity. It may be beneficial for clinicians to remember the coexistence of genetic syndromes in patients diagnosed with ASD and to request consultations from relevant departments for early diagnosis and treatment

Sertraline-Induced Amotivationel Syndrome in a 12-Year-Old Girl

Sertraline is a safe and effective agent frequently used in the treatment of childhood depression and obsessive compulsive disorder. Amotivational syndrome is also an important clinical manifestation characterized by decreased capacity to make and carry out long-term plans and lack of motivation. This report describes the development of amotivational syndrome in a 12-year-old girl receiving sertraline monotherapy and successful management of this side effect with discontinuation of sertraline and initiation of fluoxetine therapy. This case is presented because, to the best of our knowledge, there have been very few case reports regarding the development of sertraline-related amotivational syndrome and, more importantly, because of the very low number of case reports in which amotivational syndrome was managed by switching to a different selective serotonin reuptake inhibitor

Relationship between otorhinologic trauma and Attention Deficit Hyperactivity Disorder symptoms in children

Objevtives: Otorhinologic trauma is an important condition at the ear, nose and throat (ENT) outpatient clinic in children. Attention deficit hyperactivity disorder (ADHD) has been identified as a potential risk factor that may contribute to the incidence of traumatic injuries. The aim of the study was to investigate whether there is an association between otorhinologic trauma and ADHD symptoms in children