21 research outputs found
Relationship between tei index and left ventricular geometric patterns in a hypertensive population: a cross-sectional study
Assessment of the left ventricular function in normotensive prediabetics: a tissue Doppler echocardiography study
Tea Consumption Enhances Endothelial-Dependent Vasodilation; a Meta-Analysis
Background: Tea consumption is associated with a lower risk of cardiovascular disease including stroke. Direct effects of tea components on the vasculature, particularly the endothelium, may partly explain this association. Objective: We performed a meta-analysis of controlled human intervention studies on the effect of tea on flow-mediated dilation (FMD) of the brachial artery, a measurement of endothelial function, which is suggested to be associated with cardiovascular risk. Methods: Human intervention studies were identified by systematic search of the databases Medline, Embase, Chemical Abstracts and Biosis through March 2009 and by hand-searching related articles. Studies were selected based on predefined criteria: intervention with tea as the sole experimental variable, placebo-controlled design, and no missing data on FMD outcome or its variability. A random effects model was used to calculate the pooled overall effect on FMD due to the intake of tea. The impact of various subject and treatment characteristics was investigated in the presence of heterogeneity. Results: In total, 9 studies from different research groups were included with 15 relevant study arms. The overall absolute increase in FMD of tea vs. placebo was 2.6 % of the arterial diameter (95 % CI: 1.8-3.3%; P-value,0.001) for a median daily dose of 500 mL of tea (2–3 cups). This is a relative increase of approximately 40 % compared to the average FMD of 6.3% measured under placebo or baseline conditions. There was significant heterogeneity between studies (P-value,0.001) tha
Silent diabetic cardiomyopathy in everyday practice: a clinical and echocardiographic study
Transmission of calibration errors (input) by generalized transfer functions to the aortic pressures (output) at different hemodynamic states
Effect of coffee on endothelial function in healthy subjects: the role of caffeine
Coffee is one of the most widely used pharmacologically active
beverages. The present study was designed to evaluate the acute effect
of coffee ingestion on endothelial function in healthy individuals, and
the potential role of caffeine. We studied 17 healthy young adults (28.9
+/- 3.0 years old; nine men), who were regular non-heavy coffee
drinkers. The endothelial performance was estimated by
endothelium-dependent FMD (flow-mediated dilatation) of the brachial
artery before and 30, 60, 90 and 120 min after ingestion of a cup of
caffeinated coffee (80 mg of caffeine) or the corresponding
decaffeinated beverage (< 2 mg of caffeine) in two separate sessions,
following a randomized single-blind cross-over design. There was no
difference in baseline FMD values between the two sessions [7.78
compared with 7.07% after caffeinated and decaffeinated coffee
respectively; P = NS (not significant)]. Caffeinated coffee led to a
decline of FMD (7.78, 2.86, 2.12, 4.44 and 4.57 % at baseline, 30, 60,
90 and 120 min respectively; P < 0.001). This adverse effect was focused
at 30 (P = 0.004) and 60 min (P < 0.001). No significant effect on FMD
was found with the decaffeinated coffee session (7.07, 6.24, 5.21, 7.41
and 5.20 %; P = NS). The composite effect of the type of coffee
consumed over time on FMD was significantly different (P = 0.021). In
conclusion, coffee exerts an acute unfavourable effect on the
endothelial function in healthy adults, lasting for at least I h after
intake. This effect might be attributed to caffeine, given that
decaffeinated coffee was not associated with any change in the
endothelial performance