О Модернизации Жилищного Законодательства И Построении Эффективных Финансовых Моделей Управления Многоквартирными Домами В Современной России

The article substantiates a set of proposals for amending housing legislation aimed at building effective financial models of various ways to manage apartment buildings in modern Russia. The implementation of the proposals will allow the creation of financially sustainable management organizations in the housing and utilities sector, who receive their remuneration in legal form and are interested in the results of their financial and economic activities. The study was carried out with the financial support of the Russian Foundation for Basic Research in the framework of the research project No. 18-010-00090 “Study of the financial and economic aspects of the activities of management companies in the housing and utilities sector and the development of proposals to improve their financial sustainability.”El artículo respalda un conjunto de propuestas para enmendar la legislación de vivienda con el objetivo de construir modelos financieros efectivos de varias maneras de administrar edificios de apartamentos en la Rusia moderna. La implementación de las propuestas permitirá la creación de organizaciones de gestión financieramente sostenibles en el sector de vivienda y servicios públicos, que reciben su remuneración en forma legal y están interesados en los resultados de sus actividades financieras y económicas. El estudio se realizó con el apoyo financiero de la Fundación Rusa para la Investigación Básica en el marco del proyecto de investigación Nº 18-010-00090 "Estudio de los aspectos financieros y económicos de las actividades de las empresas de gestión en el sector de la vivienda y los servicios públicos. y el desarrollo de propuestas para mejorar su sostenibilidad financiera ". В статье обосновывается комплекс предложений по изменению жилищного законодательства, направленного на построение эффективных финансовых моделей различных способов управления многоквартирными домами в современной России. Реализация предложений позволит создать финансово устойчивые управляющие организации сферы ЖКХ, получающие свое вознаграждение в легальной форме и заинтересованные в результатах своей финансово-хозяйственной деятельности.   Исследование выполнено при финансовой поддержке Российского фонда фундаментальных исследований в рамках научного проекта № 18-010-00090 «Исследование финансово-экономических аспектов деятельности управляющих компаний в сфере ЖКХ и разработка предложений по повышению их финансовой устойчивости»

Evaluation of the prevalence of consumption of various kinds of smoking among school students of hiddle and senior classes

The article discusses the problem of the use of nicotine-containing mixtures (snus) by schoolchildren. The results of monitoring the opinions of high school students on the issues of smoking tobacco cigarettes, hookahs, electronic cigarettes and chewing tobacco are considered. Recommendations are given on the prevention of the use of nicotine-containing non-smoking mixtures among adolescents. The reason for this work was the frequent cases of snus poisoning in Russia and the death of a seventh grader in a secondary school in NovosibirskВ статье рассматривается проблема употребления никотиносодержащих смесей (снюса) школьниками. Рассмотрены результаты мониторинга мнения старшеклассников о вопросах различных видов курения. Поводом для проведения данной работы стали случаи отравления снюсом в России, в том числе в г. Екатеринбурге, а также случай смерти семиклассника средней школы в г. Новосибирске

A clinical case of congenital cytomegalovirus infection in a premature baby. Observation in the catamnesis

The purpose of the study is to demonstrate the importance of a multidisciplinary approach in the timely diagnosis and treatment of a child with congenital cytomegalovirus infection by the example of a clinical case.Цель исследования - на примере клинического случая продемонстрировать важность мультидисциплинарного подхода в своевременной диагностики и лечении ребенка с врожденной цитомегаловирусной инфекцией

Associations of changes in lipid metabolism parameters and the severity of COVID-19 infection in Novosibirsk residents

Aim. To study the associations of changes in lipid metabolism parameters and the severity of a coronavirus disease 2019 (COVID-19).Material and methods. This cross-sectional study included 270 patients aged 26-84 years (mean age, 53,09±13,22 years) who had COVID-19 within prior two months, which were divided into 3 groups: mild (1, n=128), moderate (2, n=128) and severe (3, n=14) COVID-19. Patients were assessed for body mass index (BMI), waist circumference (WC), hip circumference (HC), waist-to-hip ratio (WHR), total cholesterol, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C). In addition, atherogenic index of plasma (AIP) was calculated. Statistical processing was performed using the SPSS software package (version 13.0).Results. Patients with severe COVID-19 had significantly higher levels of TG and AIP compared with patients with moderate and mild course. BMI and WC were significantly higher in patients in groups 2 and 3 compared with patients in group 1. In women, BMI and AIP levels were significantly higher in the severe COVID-19 group compared to groups 1 and 2. HDL-C levels were lower in patients with severe COVID-19 compared to those with moderate disease. WHR was higher among men in group 3 compared with group 1.Conclusion. Patients with severe COVID-19 have higher BMI, WC, AIP, TG levels, and lower HD-C levels. The relative odds for severe COVID-19 are associated with increased WC, AIP, TG, and lower HDL-C

Modeling the structure and formation of the oil and gas potential of Riphean-Vendian deposits that belong to north-east regions of the Volga-Ural oil and gas province

The paper is devoted to the urgent problem of studying the prospects of the oil and gas potential of Riphean-Vendian sediments of poorly studied areas such as northeastern regions of the Volga-Ural oil and gas province. The paper presents the characteristic of the lithological and stratigraphic features of the structure of Riphean and Vendian deposits in the northeastern part of the Volga-Ural oil and gas province. Particular attention is paid to the basin modeling of well sections that did not fully passed through the Riphean-Vendian complex of rocks.That allows to predict oil and gas generation processes. During the research sections of three wells were modelled. Wells Keltmenskaya-1, Krasnovisherskaya-18, Borovitskaya-624 revealed Upper Proterozoic rocks in the north-east of the Perm region and the Komi Republic. Procedure features of the used software systems, phasing of the research, including gathering and input of initial data, processing of parameters, calculation and calibration of models are given. Certain challenges associated with modeling the conditions of oil and gas formation and oil and gas accumulation of Riphean and Vendian sediments of this territory are associated with insufficient information on the structure and composition of sediments, incomplete drilling of ancient sediments in wells and inconsistent geophysical data. In addition, the complexity of the reconstruction lies in the lack of information about geothermal conditions of sections, numerous interruptions in sedimentation and erosion of sediments. According to simulation results, most of the Riphean-Vendian sedimentary section is located in the main zone of oil generation. The research conducted allowed the authors to conclude that there are increased prospects to discover oil hydrocarbons in a wide range of depths in the areas where the Krasnovisherskaya-18 and Borovitskaya-624 wells are drilled. There is a little likelihood that gaseous hydrocarbons can be found in the section. Conducted research and obtained results pose a problem for the development of geological exploration in the poorly studied areas of the northeast of the Volga-Ural oil and gas province. First of all, that corresponds to reference-parametric drilling together with the zonal-regional geophysical studies

Non-alcoholic fatty liver disease and metabolic liver dysfunction in the new coronavirus infection COVID-19

Our study aimed to explore associated non-alcoholic fatty liver disease (NAFLD) and metabolic liver dysfunction influence on the severity of the new coronavirus infection COVID-19. Material and methods. The study design was a cross-sectional study. The research included 215 patients (39.50 % of men) aged 26–60 years who had undergone a new coronavirus infection COVID-19 at least two months ago. Participants were divided into three groups by severity of infection: mild (n = 99), moderate and severe (n = 116) by anamnesis. Hepatic steatosis index (HIS), body mass index (BMI), waist circumference, alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, systolic and diastolic pressure were calculated and abdominal ultrasound examination was done. Results. In the group with moderate and severe course of COVID-19, the proportion of patients diagnosed with NAFLDaccording to the HSI index was significantly higher compared to patients with mild coronavirus infection. Patients with mild COVID-19, who were diagnosed with NAFLD, had higher alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, BMI, systolic and diastolic pressure, waist circumference compared to patients without NAFLD. Similar differences persisted for patients with moderate and severe course. With the step-by-step exclusion of cardiometabolic parameters from the logistic regression model, the triglyceride content and BMI retained association with steatohepatosis according to ultrasound data, regardless of severity. When creating a similar model for the HSI index, significant correlation was shown for alanine aminotransferase activity in patients with mild COVID-19, for alanine aminotransferase activity and BMI – in patients with moderate and severe COVID-19. Conclusions. Patients with NAFLD have a more severe course of COVID-19. In addition, associations of the severity of COVID-19 with a combination of NAFLD and other cardiometabolic changes in the body, such as arterial hypertension, obesity, dyslipidemia, were revealed

Limitations and opportunities of cancer treatment in the COVID-19 pandemic

The COVID-19 pandemic has affected all medical fields and brought up a lot of serious problems. The features of the COVID-19 infection in patients with cancer are important to understand. According to many articles, patients with cancer are more vulnerable to COVID-19 infection. Patients undergoing anticancer treatment have 1-4% morbidity rate. Patients with hematological diseases and lung cancer are at higher risk of SARS-CoV-2 infection and also have more severe symptoms and complications. In this article we discuss the effect of the tumors on the immune system and comprehend the pathogenesis of the coronavirus disease according to its impact on the immunity. Moreover, in the review we analyze available data about the influence of the different types of cancer therapy (chemotherapy, target therapy, radiotherapy and immunotherapy) on the severity of the COVID-19 infection. Evidence on the effect of chemotherapy on severity and mortality from COVID-19 is contradictory. Whereas there are some authors concluding that chemotherapy treatment is not affecting the severity of COVID-19 disease, there are also some works where the connection between these facts was established. At the same time target therapy, radio- and immunotherapy most likely do not worsen the SARS-CoV-2 infection and are not associated with the development of complications. But it’s important to say that the amount of data available for today is insufficient to make a unambiguous conclusion

Profile of subpopulation composition of regulatory T lymphocytes and intestinal microbiota in patients with irritable bowel syndrome

The following specificcharacteristics of the composition of intestinal microbiota in patients with irritable bowel syndrome (IBS) were identified using a metagenomic analysis (16 S rRNA): 1) an increase in the representation of Actinobacteria, including Bifidobacterium spp., Firmicutes, including representatives of Streptococcaceae (Streptococcus), Lachnosperaceae (Dorea), Veillonellaceae (Dialister), Proteobacteria (Enterobacteriaceae and Desulfovibrionaceae families); 2) a decrease in the population of Bacteroidetes, including representatives of the families Prevotellacea (Prevotella spp.), Bacteroidaceae (Bacteroides spp.). Firmicutes belonging to the families Clostridiaceae and Ruminococcaceae (Fecalibacterium spp.).Flow cytometry in the study of the subpopulation composition of T regulatory (Treg) lymphocytes in patients with IBS revealed an increase in the number of CD45R0+CD62L+ central memory cells (CM), which can regulate the processes of maturation and differentiation of lymphocytes in lymphoid tissue. A decrease in the expression of exonucleases CD39 and CD73 was detected, which can have a significant effect on their activity. A reduction in effector memory cells (EM) Treg was observed.Changes in the expression level of exonucleases CD39 and CD73 were inversely correlated with the content of Proteobacteria and the representation of the genera Bifidobacterium spp. and Faecalibacterium spp. The content of СЫ Treg was directly correlated with the content of Dorea spp.The results may be indicative of impairment in the processes of Treg differentiation, which are closely related to changes in key components of intestinal microbiocenosis in IBS

Associative connection of infectious and inflammatory diseases in pregnancy and severe preeclampsia

Materials and methods. This retrospective case-control study enrolled 50 women with severe preeclampsia and 50 control women with spontaneous singleton pregnancy. Median age of women ranged from 20 to 35 years. All women did not have a history of hypertension, autoimmune, metabolic, renal, or cardiac diseases, and preeclampsia before this pregnancy. We have analyzed χ2, odds ratio (OR) and its 95% confidence intervals (95% Cl). Results. We found significant association between maternal systemic infectious and severe preeclampsia (OR = 49.6; 95% Cl 13.05-188.64). The risk of severe preeclampsia were significantly lower in patients with local infections of the lower genital tract (OR = 4.5; 95% Cl 1.49-6.71). Asymptomatic bacteriuria is associated with the highest risk of severe preeclampsia (OR = 17.0; 95% Cl 4.66-61.81). Acute gravidarum pyelonephritis showed lower association with severe preeclampsia (OR = 5.4; 95% Cl 1.69-10.54). We did not observe increased risk of severe preeclampsia with acute respiratory infections (OR = 2.0; 95% Cl 0.71-4.69). Acute non-specific bacterial vaginitis and acute candidiasis vulvovaginitis were found to be risk factors of severe preeclampsia (OR = 6.7; 95% Cl 1.90-11.02 and OR = 4.3; 95% Cl 1.45-9.99 respectively). Cytomegalovirus infection (2 %), toxoplasmosis (2 %), Chlamydia trachomatis cervicitis (4 %), acute Trichomonas colpitis (2 %) and bacterial vaginosis (4 %) were found only in patients with severe preeclampsia. Conclusion. Our data support that acute maternal infection is associated with an increased risk of severe preeclampsia in healthy women with singleton pregnancy. Systemic inflammatory response might be the main potential mechanisms related to infections and enhanced development of severe preeclampsia. Further research is required to elucidate the underlying mechanism of this association

Effect of the qualitative composition of a high-fat diet in rats with systemic inflammatory response syndrome upon myocardial resistance to ischemic-reperfusion injury and cytokine levels

Overweight and obesity are among the main factors of cardiovascular risk, but the prospective studies on the dependence between high-fat diets and weight gain yielded contradictory results. Different types of fats exert varying metabolic effects, and this fact leads to a difference in the risk associated with increasing body weight. The effects of fat quality in the daily diet on immunological status and resistance of myocardium to ischemic-reperfusion damage should be studied experimentally in biomedical models. The purpose of this work was to assess the effect of the qualitative composition of a high-fat diet used for induction of primary visceral obesity (PVO) in rats with systemic inflammatory response syndrome (SIRS) upon myocardial resistance to ischemic-reperfusion injury, and levels of pro- and anti-inflammatory cytokines.The experiments were performed on adult male Wistar rats with PVO caused by 28-day consumption of any fat types: hydrogenated fats (HF), vegetable oils (VO), animal fats (AF) or milk fat (MF). The SIRS model included a combination of chemically induced colitis (CIC) and intragastric injection of a broad-spectrum antimicrobial agent (AMA) for three days. Five days later, immunological and biochemical studies were conducted, as well as composition of intestinal microbiota in faecal samples, morphological changes in the structure of the large intestine, hemodynamic parameters and myocardial resistance to ischemic-reperfusion injury were studied in the model of isolated heart perfusion, by Langendorff technique.There was a significant increase in the concentration of anti-inflammatory cytokines in animals with SIRS, i.e., TNFα, IL-1α, IL-2, IL-8, as well as a decrease in TGF-1β, an anti-inflammatory cytokine. SIRS was accompanied by severe dietary disorders and evacuatory function of the gastrointestinal tract. Minimal changes in the intestinal microbiota composition, as well as the most pronounced regeneration signs of intestinal epithelium was observed in rats in the group with MF injection. There was a trend for increasing size of infarction in all the groups as compared with control, directly correlating with increase in BDNF and IL-2 production. However, a significant increase in the infarction size was found only in the group receiving milkfat, thus suggesting a decrease in myocardial resistance to ischemic reperfusion injury (IRI).Thus, the presence of SIRS in the primary obesity model is characterized by controllable change of inflammation markers and depends on the quality of dietary fats. The degree of morphofunctional deterioration of isolated heart, including a decrease in resistance to ischemia-reperfusion injury, correlates with the concentration of BDNF and IL-2 during the studied observation terms