Time-dependent transport through a T-coupled quantum dot

We are considering the time-dependent transport through a discrete system, consiting of a quantum dot T-coupled to an infinite tight-binding chain. The periodic driving that is induced on the coupling between the dot and the chain, leads to the emergence of a characteristic multiple Fano resonant profile in the transmission spectrum. We focus on investigating the underlying physical mechanisms that give rise to the quantum resonances. To this end, we use Floquet theory for calculating the transmission spectrum and in addition employ the Geometric Phase Propagator (GPP) approach [Ann. Phys. 375, 351 (2016)] to calculate the transition amplitudes of the time-resolved virtual processes, in terms of which we describe the resonant behavior. This two fold approach, allows us to give a rigorous definition of a quantum resonance in the context of driven systems and explains the emergence of the characteristic Fano profile in the transmission spectrum.Comment: 9 pages, 4 figure

Worldline Casting of the Stochastic Vacuum Model and Non-Perturbative Properties of QCD: General Formalism and Applications

The Stochastic Vacuum Model for QCD, proposed by Dosch and Simonov, is fused with a Worldline casting of the underlying theory, i.e. QCD. Important, non-perturbative features of the model are studied. In particular, contributions associated with the spin-field interaction are calculated and both the validity of the loop equations and of the Bianchi identity are explicitly demonstrated. As an application, a simulated meson-meson scattering problem is studied in the Regge kinematical regime. The process is modeled in terms of the "helicoidal" Wilson contour along the lines introduced by Janik and Peschanski in a related study based on a AdS/CFT-type approach. Working strictly in the framework of the Stochastic Vacuum Model and in a semiclassical approximation scheme the Regge behavior for the Scattering amplitude is demonstrated. Going beyond this approximation, the contribution resulting from boundary fluctuation of the Wilson loop contour is also estimated.Comment: 37 pages, 1 figure. Final version to appear in Phys.Rev.

Worldline Approach to Forward and Fixed Angle fermion-fermion Scattering in Yang-Mills Theories at High Energies

Worldline techniques are employed to study the general behaviour of the fermion-fermion collision amplitude at very high energies in a non-abelian gauge field theory for the forward and fixed angle scattering cases. A central objective of this work is to demonstrate the simplicity by which the worldline methodology isolates that sector of the full theory which carries the soft physics, relevant to each process. Anomalous dimensions pertaining to a given soft sector are identified and subseuently used to facilitate the renormalization group running of the respective four point functions. Gluon reggeization is achieved for forward, while Sudakov suppression is established for fixed angle scattering.Comment: 28 pages, 10 figures in three file

Cytolytic T-cell response against Epstein-Barr virus in lung cancer patients and healthy subjects

<p>Abstract</p> <p>Background</p> <p>This study aimed to examine whether EBV seropositive patients with lung cancer have an altered virus-specific CTL response, as compared to age-matched healthy controls and whether any variation in this response could be attributed to senescence.</p> <p>Methods</p> <p>Peripheral blood mononuclear cells from lung cancer patients, age-matched and younger healthy individuals were used to measure EBV-specific CTLs after in vitro amplification with the GLCTLVAML and RYSIFFDYM peptides followed by HLA-multimer staining.</p> <p>Results</p> <p>Lung cancer patients and aged-matched controls had significantly lesser EBV-specific CTL than younger healthy individuals. Multimer positive populations from either group did not differ with respect to the percentage of multimer positive CTLs and the intensity of multimer binding.</p> <p>Conclusions</p> <p>This study provides evidence that patients with lung cancer exhibit an EBV-specific CTL response equivalent to that of age-matched healthy counterparts. These data warrant the examination of whether young individuals have a more robust anti-tumor response, as is the case with the anti-EBV response.</p

Foxp3 Expression in Liver Correlates with the Degree but Not the Cause of Inflammation

Patients with chronic viral hepatitis display increased expression of Foxp3 in liver, suggesting that Tregs expansion contributes to persistent infection. The purpose of this study was to elucidate whether the expression of Foxp3 relates not to the viral infection but to the resulting liver inflammation. Liver biopsies obtained from 69 individuals (26 chronic HBV hepatitis, 14 chronic HCV hepatitis, 11 nonalcoholic fatty liver disease, 8 autoimmune diseases, 2 methotrexate-related toxicity, and 8 controls) were examined, by qRT-PCR, for the mRNA expression of Foxp3, IL-10, TGF-β1, Fas, FasL, TRAIL, caspase-3, TNF-α, IFN-γ, and IL-1β. Significant increase of Foxp3 was observed in all disease groups compared to controls, which was positively correlated with the intensity of inflammation. The expression of the apoptosis mediators Fas, FasL, and TRAIL, but not of IL-10 and TGF-β1, was also significantly elevated. Our findings indicate that, independently of the initial inducer, liver inflammation is correlated with elevated expression of apoptosis mediators and is followed by local Treg accumulation. Further research towards the elucidation of the underlying casual relationships is required, in order to clarify whether our results signify the existence of a uniform Treg-mediated regulatory mechanism of apoptosis-induced inflammation

Evaluation of [18F]-FDG-Based Hybrid Imaging Combinations for Assessment of Bone Marrow Involvement in Lymphoma at Initial Staging.

The purpose of our study was to determine the value of different hybrid imaging combinations for the detection of focal and diffuse bone marrow infiltration in lymphoma. Patients with histologically proven lymphoma, who underwent both [18F]-FDG-PET/CT and whole-body MRI (including T1- and diffusion-weighted [DWI] sequences) within seven days, and a subsequent bone marrow biopsy, were retrospectively included. Three hybrid imaging combinations were evaluated: (1) [18F]-FDG-PET/CT; (2) [18F]-FDG-PET/T1; and (3) [18F]-FDG-PET/DWI. The presence of focal or diffuse bone marrow infiltration was assessed by two rater teams. Sensitivity, specificity, and accuracy for the detection of overall, focal, and diffuse bone marrow involvement were compared between the three hybrid imaging combinations. Overall, lymphomatous bone marrow involvement was found in 16/60 patients (focal, 8; diffuse, 8). Overall sensitivity, specificity, and accuracy were 81.3%, 95.5%, and 91.7% for [18F]-FDG-PET/CT; 81.3%, 97.7%, and 93.3% for [18F]-FDG-PET/T1; and 81.3%, 95.5%, and 91.7% for [18F]-FDG-PET/DWI. No statistically significant differences between the three imaging combinations were observed, based on overall bone marrow involvement, focal involvement, or diffuse involvement. The sensitivity of all three imaging combinations for detecting diffuse bone marrow involvement was only moderate (62.5% for all three combinations). Although the combination of [18F]-FDG-PET and T1-weighted MRI generally showed the best diagnostic performance for the detection of bone marrow involvement in lymphoma, it was not significantly superior to the two other hybrid imaging combinations. Since the sensitivity of all imaging combinations for the detection of diffuse bone marrow involvement was only moderate, bone marrow biopsy cannot be replaced by imaging as yet

Gauge (non-)invariant Green functions of Dirac fermions coupled to gauge fields

We develop a unified approach to both infrared and ultraviolet asymptotics of the fermion Green functions in the condensed matter systems that allow for an effective description in the framework of the Quantum Electrodynamics. By applying a path integral representation to the previously suggested form of the physical electron propagator we demonstrate that in the massless case this gauge invariant function features a "stronger-than-a-pole" branch-cut singularity instead of the conjectured Luttinger-like behavior. The obtained results alert one to the possibility that construction of physically relevant amplitudes in the effective gauge theories might prove more complex than previously thought