Effects of inspiratory muscle training on functional exercise capacity and quality of life in patients with sarcoidosis

Sarkoidoz hastalarında azalan solunum kas kuvveti hastaların fonksiyonel egzersiz kapasitesindeki azalma, yorgunluk, nefes darlığı algısı ve yaşam kalitesindeki kötüleşme ile ilişkilidir; ancak, inspiratuar kas eğitiminin etkilerini araştıran çalışma yoktur. Bu nedenle çalışmamız sarkoidoz hastalarında inspiratuar kas eğitiminin fonksiyonel egzersiz kapasitesi, solunum kas kuvveti, solunum fonksiyonları, nefes darlığı, yorgunluk algısı ve yaşam kalitesi üzerine etkilerini araştırmak üzere rastgelelenmiş,kontrollü, ileriye dönük ve çift kör olarak planlandı. On dört hastaya (tedavi grubu) maksimum inspiratuar basıncın %40?ında (MİP), 15 hastaya (kontrol grubu) ise, MİP?in %5?inde altı hafta boyunca inspiratuar kas eğitimi uygulandı. Tedavi öncesi ve sonrası hastaların solunum fonksiyonları ve akciğer karbonmonoksit difüzyon kapasitesi spirometre ile, fonksiyonel egzersiz kapasitesi altı dakika yürüme testi ile, solunum kas kuvveti ağız basınç ölçüm cihazı ile, yorgunluk algılaması Yorgunluk Şiddet Ölçeği ile, nefes darlığı Modifiye Borg ve Modifiye Medical Research Council dispne ölçekleri ile, yaşam kalitesi Saint George?s Solunum ölçeği ile değerlendirildi. İnspiratuar kas eğitimi sonrası tedavi grubunun fonksiyonel egzersiz kapasitesi, solunum kas kuvveti arttı, yorgunluk ve nefes darlığı algısı azaldı. Grupların yaşam kalitesi algıları aynı oranda iyileşti (p0.05). Sonuç olarak, sarkoidoz hastalarında uygulanan inspiratuar kas eğitimi hastaların fonksiyonel egzersiz kapasitesini ve solunum kas kuvvetini arttır, nefes darlığı ve yorgunluk algısını azaltır; pulmoner rehabilitasyon programlarına etkin ve güvenilir bir şekilde dahil edilmelidir.Reduced respiratory muscle strength is related with decreased functional exercise capacity, worse fatigue, dyspnea and quality of life perception in patients with sarcoidosis. However, no study investigated the effects of inspiratory muscle training in patients with sarcoidosis. Therefore, the purpose of this double-blinded, prospective and randomized controlled study was to investigate the effects of inspiratory muscle training on functional exercise capacity, respiratory muscle strength, pulmonary functions, dyspnea, fatigue and quality of life in patients with sarcoidosis. Fourteen patients (treatment group) received inspiratory muscle training at %40 of maximal inspiratory pressure (MlP), and 15 patients (control group) received sham therapy (%5 of MlP) for 6 weeks. Before and after treatment, pulmonary function and pulmonary diffusing capacity using spirometry, functional exercise capacity using 6-minute walk test,respiratory muscle strength using mouth pressure device, fatigue using Fatigue Severity Scale, dyspnea using Modified Borg and Modified Medical Research Council dyspnea scales, quality of life using Saint George?s Respiratory Questionnaire were evaluated. Functional exercise capacity, respiratory muscle strength, fatigue and dyspnea perception were significantly improved in the treatment group compared with controls;fatigue and quality of life perception were similarly improved within groups(p0.05). In conclusion, inspiratory muscle training improves functional exercise capacity and respiratory muscle strength; decreases dyspnea and fatigue perception in patients with sarcoidosis and should be included safely and effectively in pulmonary rehabilitation programs

Effects of Inspiratory Muscle Training in Subjects With Sarcoidosis: A Randomized Controlled Clinical Trial.

Respiratory muscle weakness occurs in sarcoidosis and is related to decreased exercise capacity, greater fatigue, dyspnea, and lower quality of life in sarcoidosis patients. The effects of inspiratory muscle training in this population have not been comprehensively investigated so far. This study was planned to investigate the effects of inspiratory muscle training on exercise capacity, respiratory and peripheral muscle strength, pulmonary function and diffusing capacity, fatigue, dyspnea, depression, and quality of life in subjects with sarcoidosis

The Role of Inspiratory Muscle Training in Sickle Cell Anemia Related Pulmonary Damage due to Recurrent Acute Chest Syndrome Attacks.

Background. The sickling of red blood cells causes a constellation of musculoskeletal, cardiovascular, and pulmonary manifestations. A 32-year-old gentleman with sickle cell anemia (SCA) had been suffering from recurrent acute chest syndrome (ACS). Aim. To examine the effects of inspiratory muscle training (IMT) on pulmonary functions, respiratory and peripheral muscle strength, functional exercise capacity, and quality of life in this patient with SCA. Methods. Functional exercise capacity was evaluated using six-minute walk test, respiratory muscle strength using mouth pressure device, hand grip strength using hand-held dynamometer, pain using Visual Analogue Scale, fatigue using Fatigue Severity Scale, dyspnea using Modified Medical Research Council Scale, and health related quality of life using European Organization for Research and Treatment of Cancer QOL measurement. Results. A significant improvement has been demonstrated in respiratory muscle strength, functional exercise capacity, pain, fatigue, dyspnea, and quality of life. There was no admission to emergency department due to acute chest syndrome in the following 12 months after commencing regular erythrocytapheresis. Conclusion. This is the first report demonstrating the beneficial effects of inspiratory muscle training on functional exercise capacity, respiratory muscle strength, pain, fatigue, dyspnea, and quality of life in a patient with recurrent ACS