42 research outputs found
Metallicity Calibration and Photometric Parallax Estimation: I. UBV photometry
We present metallicity and photometric parallax calibrations for the F and G
type dwarfs with photometric, astrometric and spectroscopic data. The sample
consists of 168 dwarf stars covering the colour, iron abundance and absolute
magnitude intervals mag, dex and
mag, respectively. The means and standard deviations of the
metallicity and absolute magnitude residuals are small, i.e.
and dex, and and mag, respectively, which indicate
accurate metallicity and photometric parallax estimations.Comment: 13 pages, 11 figures and 2 tables, accepted for publication in
Astrophysics and Space Scienc
Local Stellar Kinematics from RAVE data - VII. Metallicity Gradients from Red Clump Stars
We investigate the Milky Way Galaxy's radial and vertical metallicity
gradients using a sample of 47,406 red clump stars from the RAVE DR4. This
sample is more than twice the size of the largest sample in the literature
investigating radial and vertical metallicity gradients. The absolute magnitude
of Groenewegen (2008) is used to determine distances to our sample stars. The
resulting distances agree with the RAVE DR4 distances Binney et al. (2014) of
the same stars. Our photometric method also provides distances to 6185 stars
that are not assigned a distance in RAVE DR4. The metallicity gradients are
calculated with their current orbital positions ( and ) and with
their orbital properties (mean Galactocentric distance, and ),
as a function of the distance to the Galactic plane:
d[Fe/H]/d- dex/kpc for kpc and
d[Fe/H]/d- dex/kpc for kpc. This
reaffirms the radial metallicity gradient in the thin disc but highlights that
gradients are sensitive to the selection effects caused by the difference
between and . The radial gradient is flat in the distance
interval 0.5-1 kpc from the plane and then becomes positive greater than 1 kpc
from the plane. The radial metallicity gradients are also eccentricity
dependent. We showed that d[Fe/H]/d-, -,
- and - dex/kpc for , ,
and sub-samples, respectively, in the distance
interval kpc. Similar trend is found for vertical
metallicity gradients. Both the radial and vertical metallicity gradients are
found to become shallower as the eccentricity of the sample increases. These
findings can be used to constrain different formation scenarios of the thick
and thin discs.Comment: 18 pages, including 16 figures and 6 tables, accepted for publication
in PAS
Investigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitus
Introduction: Non insulin dependent diabetes mellitus is the most common type of diabetes. Genetic factors, lipid profiles, hypertension are potential risk factors for diabetes mellitus. Adenosine binding cassette transporter proteins 1 (ABCA1) plays a role in cholesterol metabolism, especially high density lipoprotein (HDL-cholesterol). There are multiple mechanisms by which HDL-cholesterol can be atheroprotective, it is clear that the relative activity of ABCA1 plays a major role. We aimed to in-vestigate association of ABCA1 C69T gene polymorphism with lipid levels in Turkish type 2 diabetic patients.
Materials and methods: After isolation of DNA by ethanol precipitation we determined ABCA1 gene polymorphism by using polimerase chain reaction - restriction fragment lenght polymorphism (PCR-RFLP) method in 107 type 2 diabetic patients and 50 healthy controls.
Results: We have observed that the frequency of TT genotype is significantly higher in healthy con-trols compared to patients (14% vs. 3%; P = 0.008). Also frequency of T allele was higher in controls than in patients (34% vs. 21%; P = 0.020; OR (95% CI) = 0.52 (0.30-0.88)). There was no association of lipid levels and ABCA1 C69T polymorphism subgroups.
Conclusion: We have found significantly higher frequency of both T allele and genotype in control group when compared to patients that made us think that T allele may be a protective factor against diabetes mellitus. But, we could not find a relationship between genotypes and lipid concentrations in our two groups. Larger studies will help us to understand the relationship between ABCA1 C69T genotype and lipid parameters in diabetes mellitus
Paraoxonase 55 and 192 polymorphism and its relationship to serum paraoxonase activity and serum lipids in Turkish patients with non-insulin dependent diabetes mellitus
We investigated the effect of PON 55 and PON 192 polymorphisms on serum PON1 activity and lipid profiles in 213 non-insulin dependent diabetes mellitus (NIDDM) individuals and 116 non-diabetic controls among Turkish subjects. The distribution of PON 55/192 gene polymorphism was determined by polymerase chain reaction-based restriction fragment length polymorphism. Serum lipid levels were measured enzymically. PON activity was measured by spectrophotometric assay of p-nitrophenol production following addition of paraoxon. We found that PON 55 and 192 genotype distribution was similar in patients and controls and paraoxonase activity was generally lower in diabetics than in control subjects. We showed that PON 55 and 192 genotypes have a major effect on serum PON activity. PON 192 BB homozygotes had significantly higher PON activity than AA and AB genotypes among the control and NIDDM populations (p < 0.001). PON 55 MM homozygotes had significantly lower PON activity than did LL and LM genotypes in control and NIDDM populations (p < 0.05). The PON1 55 and 192 polymorphisms did not consistently influence the serum lipid profiles in either population. In conclusion, our results suggest that the paraoxonase activities are affected by PON I genetic variability in Turkish NIDDM patients and controls. Copyright (C) 2004 John Wiley Sons, Ltd
Serum paraoxonase activity, and genotype distribution in diabetes mellitus and its relationship to serum lipids
An Association between MPO-463 G/A Polymorphism and Type 2 Diabetes
Myeloperoxidase (MPO) is an enzyme which is a member of the haem-peroxidase superfamily and plays a role in production of reactive oxygen species. The most common polymorphism in the promoter region of MPO gene is -463 G/A. It was shown that carrying the GG genotype means increased activity of the gene approximately 2-3-fold compared to GA and AA genotypes. It was found that hyperglycaemia, modified oxidized proteins and increased advanced glycosylated end products (AGE) are related to oxidative stress in diabetes. Under the hyperglycaemic conditions, production of reactive oxygen radical is elevated in smooth muscle endothelial cells, mesengial and tubular endothelial cells. Especially, elevated lipid oxidation plays an important role in pathogenesis of diabetic complications such as cardiovascular complications. We examined the MPO -463 G/A polymorphism by using the PCR-RFLP method in 145 type 2 diabetic patients and 151 healthy controls. We observed that the AA genotype and A allele were protective variants against type 2 diabetes and the GG genotype was a risk factor for diabetes. While we studied the relationship between genotypes and biochemical parameters, we found that patients with the A allele had decreased serum cholesterol, triglyceride, VLDL levels and body mass index. We suggest that the MPO gene has an important role in pathogenesis of type 2 diabetes because of the increased frequency of GG genotype, which is related to increased activity and oxidant capacity of MPO in the patients
Investigation of ABCA1 C69T polymorphism in patients with type 2 diabetes mellitus.
Introduction: Non insulin dependent diabetes mellitus is the most common type of diabetes. Genetic factors, lipid profiles, hypertension are potential risk factors for diabetes mellitus. Adenosine binding cassette transporter proteins 1 (ABCA1) plays a role in cholesterol metabolism, especially high density lipoprotein (HDL-cholesterol). There are multiple mechanisms by which HDL-cholesterol can be atheroprotective, it is clear that the relative activity of ABCA1 plays a major role. We aimed to investigate association of ABCA1 C69T gene polymorphism with lipid levels in Turkish type 2 diabetic patients
Local Stellar Kinematics from RAVE Data - VI. Metallicity Gradients Based on the F-G Main-Sequence Stars
We estimated iron and metallicity gradients in the radial and vertical directions with the F and G type dwarfs taken from the Radial Velocity Experiment Data Release 4 database. The sample defined by the constraints Z(max) 8 kpc. The range of the iron and metallicity abundance for the F and G type dwarfs on elongated orbits, [-0.13, -0.01), is similar to the thin-disc stars, while at least half of their space velocity components agree better with those of the thick-disc stars. The vertical iron gradients estimated for the F and G type dwarfs on circular orbits are d[Fe/H]/dZ(max) = -0.176 +/- 0.039 dex kpc(-1) and d[Fe/H]/dZ(max) = -0.119 +/- 0.036 dex kpc(-1) for the intervals Z(max) <= 825 and Z(max) <= 1500 pc, respectively