23 research outputs found
The effect of myocardial fibrosis on left ventricular torsion and twist in patients with non-ischemic dilated cardiomyopathy
Background: Left ventricular (LV) rotation, twist, and torsion are important aspects of thecardiac performance. Myocardial fibrosis can be identified as the late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR). In this study, we investigated the associationbetween myocardial fibrosis and LV rotational parameters in patients with nonischemic dilated cardiomyopathy (NDC).Methods: Twenty-two NDC patients were enrolled. LV dimensions, volumes and ejection fraction (EF) were measured, conventional tissue Doppler imaging data was acquired. Speckletracking imaging was performed to measure LV deformation, LV rotational parameters. Bloodsamples were obtained for NT-proBNP. Late gadolinium enhanced cardiac magnetic resonance (LGE-CMR) was used to assess cardiac fibrosis index.Results: Myocardial deformation was similar between LGE+ and LGE– groups. LGE+patients have significantly higher basal and lower apical systolic rotation, lower twist andtorsion when compared to LGE– patients. However, untwisting rate was similar between thegroups. Torsion was significantly correlated with LVEF and MR-index. Patients with reversedapical systolic rotation had significantly greater NT-proBNP values, basal systolic rotation andsignificantly lower apical systolic rotation, torsion, and MR-index.Conclusions: Cardiac fibrosis index is closely related with myocardial torsion and LV systolicfunction and may be used for the evaluation of cardiac condition. Reversed apical systolicrotation indicated more extensive cardiac fibrosis as it may reflect severe LV dyssynchrony andpoor LV performance
Impairment of the left ventricular systolic and diastolic function in patients with non-alcoholic fatty liver disease
Background: Non-alcoholic fatty liver disease (NAFLD) is considered the liver component of
the metabolic syndrome. We investigated the diastolic and systolic functional parameters of
patients with NAFLD and the impact of metabolic syndrome on these parameters.
Methods: Thirty-five non-diabetic, normotensive NAFLD patients, and 30 controls, were
included in this study. Each patient underwent transthoracic conventional and tissue Doppler
echocardiography (TDI) for the assessment of left ventricular (LV) diastolic and systolic function.
Study patients were also evaluated with 24-hour ambulatory blood pressure monitoring.
Results: NAFLD patients had higher blood pressures, increased body mass indices, and more
insulin resistance than controls. TDI early diastolic velocity (E’ on TDI) values were lower in
NAFLD patients than the controls (11.1 ± 2.1 vs 15.3 ± 2.7; p < 0.001). TDI systolic velocity
(S’ on TDI) values were lower in NAFLD patients than the controls (9.34 ± 1.79 vs 10.6 ± 1.52;
p = 0.004). E’ on TDI and S’ on TDI values were moderately correlated with night-systolic
blood pressure, night-diastolic blood pressure, and night-mean blood pressure in NAFLD patients.
Conclusions: Patients with NAFLD have impaired LV systolic and diastolic function even in
the absence of morbid obesity, hypertension, or diabetes. (Cardiol J 2010; 17, 5: 457-463
The association of functional mitral regurgitation and anemia in patients with non-ischemic dilated cardiomyopathy
Background: We investigated the association between anemia and functional mitral regurgitation
(MR) in non-ischemic dilated cardiomyopathy (DCM) patients with sinus rhythm
and normal renal function.
Methods: Sixty non-ischemic DCM patients with sinus rhythm and left ventricular ejection
fraction < 40% were recruited. Functional MR was quantified with the proximal isovelocity
surface area method. MR was graded according to the mitral regurgitant volume (Reg Vol) or
effective regurgitant orifice (ERO) area. The clinical, biochemical and echocardiographic
correlates of functional MR severity were investigated in patients with DCM.
Results: Hemoglobin degrees were significantly different between various MR levels (mild
MR 13.9 ± 1.7 mg/dL, moderate MR 12.3 ± 1.5 mg/dL, moderate to severe MR 10.8 ± 0.9 mg/dL).
Receiver operating characteristic (ROC) analysis was performed to assess the utility of hemoglobin
levels to predict moderate or severe functional MR. A hemoglobin level less than
12.5 mg/dL predicted moderate or high MR with 80% sensitivity and 58% specificity (AUC:
0.789, 95% CI: 0.676–0.901, p < 0.0001). Logistic regression analysis was performed to
determine the independent predictors of moderate or severe levels of MR. The left atrium
diameter (OR: 19.3, 95% CI: 1.4-27.1, p = 0.028) and presence of anemia (OR: 11.9,
95% CI: 1.22-42.5, p = 0.0045) were independent predictors of moderate or severe functional MR.
Conclusions: The presence of anemia and enlarged left atrium are independent predictors of
moderate or severe functional MR in non-ischemic DCM patients with normal renal function.
Hemoglobin levels less than 12.5 mg/dL should alert the physician for the presence of moderate
or severe MR in patients with DCM. (Cardiol J 2010; 17, 3: 274-280