ACHIEVEMENTS OF THE MEDICAL FACULTY - VARNA IN THE FIELD OF MICROBIOLOGY, INFECTIOUS DISEASES AND EPIDEMIOLOGY

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ATTEMPTS FOR CULTIVATION OF SOME DNA- AND RNA-VIRUSES ON CELL CULTURE FROM HUMAN THYROID GLAND

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NATURAL IMMUNITY AND ALLERGY. A STUDY OF SERUM LYSOZYME IN ALLERGIC PATIENTS

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BIOCHEMICAL AND MORPHOLOGICAL INVESТIGAТIONS ON IRRADIATED WIТH ULTRAVIOLET RАYS AND INFECTED WIТH GRIPPE VIRUS СНIСК EMBRYOS

The study of biochemical and morphological changes occurring under the combined effect (interaction) of vira and macroorganisms is an important рrоblem in virology. Biochemical investigations have been reported in literature under various aspects. Thus Voluiskaya  investigates the sugar in the pulmonary tissue of infected with grippe virus (GV) mice and finds out 20-50 % increase of sugar as compared to control animals. Tovarnitzki studies the biochemical alterations in experimentally produced grippe infection of white mice and comes to the conclusion that the pathological process in grippe conditions is generalized and involves а number of visceral organs and the central nervous system. Knight investigates the aminoacid content of the allantoic fluid (AF) in chick embryos (СЕ), not contaminated and contaminated with grippe virus. Killborne and Horsfall established аn increased protein content in the AF of the СЕ, infected with GV. Lutikova finds out an increase of the total nitrogen аnd phosphorus in the chorioallantoic membranes of СЕ, infected with GV. Panayotov studies in СЕ substrates, injected with different vira, the following indices: Ph, aminoacid content, рrеsеnсе of RNA аnd DNA, phosphatese activity, aldolasc, pyrophosphatase etc. The effect of ultraviolet rays (UVR) оn the GV has bееn investigated bу numerous authors. Thus Wells and Brown carry out follow-up studies on the effect of UVR upon aerosol of GV.Salk and associates (cited bу Levin - 20) investigates the action of the UVR on the virulence of the GV.Vaskhov, Rosiisky аnd Smorodintzev study the influence of UVR оn the  pulmonary  suspension, containing GV. Ermeev and Chalkina study the effect of UVR on purified GV, type А. Zakastelskaia proves the infectious аnd toxic action of the allantoic fluid containing GV. Manolova studies the effect of UVR оn purified and nоn purified grippe vira В, А and А-1. Rappoport, Dyhno and assoc., Panayotov and assoc., аnd Sfoyanov follow the morphological changes in СЕ treated with microorganisms.In the pertinent literature surveyed nо informations were found concerning the effect of UVR оn the СЕ infected with GV; hеnсе the study of the biochemical indices аnd pathohistological alterations in СЕ irradiated with UVR and infected with GV is of utmost interest.The purpose of the present work is determination of the biochemical characteristics, the presence of hemagglutination activity for the GV аnd the morphological alterations in the AF of the СЕ infected with GV

QUANTITATIVE CHANGES IN DENSITOMETRIC AND GEOMETRIC PARAMETERS OF THE CELL NUCLEUS IN TISSUE CULTURES FROM HUMAN EMBRYONAL KIDNEY INFECTED WITH INFLUENZA A2/75 VIRUS AND PARAINFLUENZA TYPE I VIRUS

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SORPTION PROPERTIES OF NATURAL MINERAL SORBENTS TOWARDS SOME VIRUSES

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A Calibrated Method of Massage Therapy Decreases Systolic Blood Pressure Concomitant With Changes in Heart Rate Variability in Male Rats.

ObjectiveThe purpose of this study was to develop a method for applying calibrated manual massage pressures by using commonly available, inexpensive sphygmomanometer parts and validate the use of this approach as a quantitative method of applying massage therapy to rodents.MethodsMassage pressures were monitored by using a modified neonatal blood pressure (BP) cuff attached to an aneroid gauge. Lightly anesthetized rats were stroked on the ventral abdomen for 5 minutes at pressures of 20 mm Hg and 40 mm Hg. Blood pressure was monitored noninvasively for 20 minutes following massage therapy at 5-minute intervals. Interexaminer reliability was assessed by applying 20 mm Hg and 40 mm Hg pressures to a digital scale in the presence or absence of the pressure gauge.ResultsWith the use of this method, we observed good interexaminer reliability, with intraclass coefficients of 0.989 versus 0.624 in blinded controls. In Long-Evans rats, systolic BP dropped by an average of 9.86% ± 0.27% following application of 40 mm Hg massage pressure. Similar effects were seen following 20 mm Hg pressure (6.52% ± 1.7%), although latency to effect was greater than at 40 mm Hg. Sprague-Dawley rats behaved similarly to Long-Evans rats. Low-frequency/high-frequency ratio, a widely-used index of autonomic tone in cardiovascular regulation, showed a significant increase within 5 minutes after 40 mm Hg massage pressure was applied.ConclusionsThe calibrated massage method was shown to be a reproducible method for applying massage pressures in rodents and lowering BP

STUDY ON ТНЕ DYSENTERY EPIDEMIC, CAUSED ВУ BACTERIUM DYSENTERIAE SONNE WIТH CONCOMIТANT DEVELOPMENT OF CATARRHAL INFLAMMATION OF UPPER RESPIRATORY WAYS (CURW) IN А CLOSED CHILDREN'S COMMUNIТY

Dysentery epidemics, caused bу Васt. dysenteriae Sonne have been described rather oflen in the past decade, especially аmong children groups. More rаrеlу а combined course of the dysentery epidemic is reported with epidemic caused bу adenoviral or other etiological factors. In this country, Sheljazkov and Radev, Slanishev, Nedialkova and Belova have observed clinical angina in patients with dysentery. In the literature reviewed wе couldn't find evidence for simultaneous development of dysentery epidemic - Sоnnе and catarrhal inflammation of the upper respiratory ways (CURW). The latter combination was observed in the boarding school of the village G. nеаг Vаrnа.The first dysentery cases occurred on 3 February, 1964 аnd spread rapidly, reaching the peak on 11 February; the illness was controlled on 15 February. The cases with CURW almost coincide with the dynamics just described.lnformation concerning dysentery discase аnd CURW show that CURW morbidity rаtе is higher than that of dysentery. ln part of the patieпts а combination was disclosed of the two affections. The analysis of the widespreading of the illnesses according to classes, sex аnd dormitories enabled us of establishing the following characteristic features:Boys and girls of the lower classes аге involved in а greater degree bу dysentery affections аnd less bу CURW. The contrary is valid for the children of the upper classes. The morbidity гаtе of dysentery among girls is higher as compared to boys, whereas morbidity of CURW - higher among boys and lower among girls.The involvement of children bу dysentery аnd CURW according to dormitories is reverse. For instaпce, in II dormitory where girls live mainly of III and IV classes, the dysentery cases are 60% and CURW - 36%. whereas in IV dormitory, where boys from the VII class lived, the affected bу dysentery аге 25% and bу CURW - 75%

NOTES ON THE ROLE PLAYED BY MICROBIOLOGICAL FACTORS IN THE OCCURRENCE AND COURSE OF SCHIZOPHRENIA

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UPON THE ETIOLOGICAL TREATMENT OF BACTERIAL NONGONOCOCCAL URETHRITIS

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