Tenosynovial Giant Cell Tumor of the Ankle: A Case Report with an Unusual Location

Tenosynovial giant cell tumor (TSDHT) is a slow-growing benign tumor arising from the tendon sheath or bursa. TSDHT of the foot and foot ankle has been reported much less frequently compared to the hand and knee. Morphologically it is classified as the localized form, often seen in the hand, and the diffuse form seen in large joints. Therefore, TSGCT should be considered in the differential diagnosis of the foot and ankle soft tissue tumors. Clinical and radiological findings of the intra-articular localized form of TSGCT in the ankle were presented in this study

NASDAQ FİNANSAL TEKNOLOJİ ENDEKSİ ŞİRKETLERİNDE KÂRLILIĞI ETKİLEYEN FİNANSAL ORANLARIN ARAŞTIRILMASI

ÖZ: Finans sektöründe teknolojik yenilikleri etkin bir şekilde kullanan ve uygulayan şirketler finansal teknoloji (FinTek) şirketi olarak ifade edilmektedir. FinTek şirketleri, genel olarak günümüzde ödeme, API sağlayıcıları, kripto para, bireyler arası borçlanma, muhasebe, denetim, kişisel finans, ulusal/uluslararası para transferleri, kitlesel fonlama, kredi gibi faaliyetlerde bulunmaktadır. FinTek şirketlerinin geleneksel finans şirketlerine rakip olup olmayacakları veya beraber hareket edip etmeyecekleri konusu halen bir tartışma konusudur. Bu tartışma nasıl sonuçlanırsa sonuçlansın neticede FinTek şirketleri de geleneksel olarak ifade edilen mevcut finans sektöründeki şirketler gibi analizlerle araştırılmaktadır. Literatürde performans ölçümünde en sık kullanılan yöntem oran analizi yöntemidir. Bu çalışmanın amacı, KBW NASDAQ Finansal Teknoloji Endeksinde (KFTX) faaliyet gösteren FinTek şirketlerinin finansal oranları ile kârlılık arasındaki ilişkinin araştırılmasıdır. NASDAQ Finansal Teknoloji Endeksi, KBW Yatırım Bankası, Stifel finansal şirketi ve Nasdaq tarafından 2016 yılından itibaren ortaklaşa açıklanan ve ağırlıklı olarak büyük veri, dövize dayalı işlemler ve ödeme ile uğraşan etkili FinTek şirketlerini içeren FinTek endeksidir. KBW’ye göre, bu şirketler ABD finans sektörünün %18’ini oluşturmakta ve 785 milyar dolarlık piyasa değerine sahiptir. KBW NASDAQ Finansal Teknoloji Endeksindeki şirketlerinin 2016-2021 yılları arasındaki finansal tablolarından elde edilen finansal oranlar çalışmada kullanılan değişkenlerdir. Çalışmanın analiz kısmında değişkenler arasındaki ilişkiyi ölçmek için panel regresyon modelleri kullanılmıştır. Çalışmada oluşturulan modellerdeki bağımlı değişkenler aktif kârlılığı (ROA) ve öz sermaye kârlılığıdır (ROE) ve bağımsız değişkenler ise kaldıraç oranı, cari oran, brüt kâr marjı, aktif devir hızı, alacak devir hızı ve borç devir hızıdır. ABSTRACT: Companies that effectively use and implement technological innovations in the financial sector are referred to as financial technology (FinTech) companies. Today, FinTech companies generally are engaged in activities such as payment, API providers, crypto money, interpersonal borrowing, accounting, auditing, personal finance, national/international money transfers, crowdfunding, and loans. The issue of whether FinTech companies will compete with traditional financial companies or act together is still a matter of debate. No matter how this discussion turns out, FinTech companies are also researched with analyses like the companies in the traditionally expressed financial sector. In the literature, the most frequently used method in performance measurement is the ratio analysis method. The aim of this study is to investigate the relationship between the financial ratios and profitability of FinTech companies operating in the KBW NASDAQ Financial Technology Index (KFTX). The NASDAQ Financial Technology Index is a FinTech index jointly announced by KBW Investment Bank, Stifel Financial Corporation and Nasdaq in 2016, and includes influential FinTech companies predominantly engaged in big data, currency-based transactions and payment. According to KBW, these companies make up 18% of the US financial sector and have a market capitalization of $785 billion. The financial ratios obtained from the financial statements of the companies in the KBW NASDAQ Financial Technology Index between the years 2016-2021 are the variables used in the study. In the analysis part of the study, panel regression models were used to measure the relationship between the variables. The dependent variables in the models created in the study are return on assets (ROA) and return on equity (ROE) and the independent variables are leverage ratio, current ratio, gross profit margin, asset turnover, receivables turnover and debt turnover

Non-Specific Medical Treatment Methods in Female Infertility

Infertility, which is defined as the inability to conceive despite one year of unprotected sexual intercourse, affects 15% of couples. Any patient with infertility by definition or at high risk of infertility may be offered an infertility evaluation. In women older than 35 years, this waiting period can be limited to 6 months, and then infertility evaluation can be started. In women older than 40 years, more urgent evaluation and initiation of treatment is the most important option. Evaluation of infertility must be done by experienced and trained physicians and necessary treatments must be followed by these physicians. Alternative treatment methods can be used in patients who do not respond after standard evaluation steps and generally accepted treatment options. Various supportive treatments come to the fore here. These options are used both to obtain better quality oocytes before treatment and to ensure that more follicles participate in stimulation. Antioxidants and metformin are the most commonly used agents before treatment in women who are thought to have insulin resistance, especially considering that oocyte mitochondrial DNA damage increases in advanced female age. On the other hand, agents such as growth hormone that should be used in a controlled manner by experienced specialists have been found effective in many publications. In the presented article, non-conventional treatment options for infertility are explained

Okul çağındaki çocuklarda diş hekimi ziyaret sıklığının çürük deneyimi ve ağız sağlığı faktörleri üzerine etkisi

Amaç: Bu çalışmada okul çağındaki çocuklarda diş hekimi ziyaret sıklığının çürük deneyimi ve ağız sağlığı faktörleri üzerine etkisi incelenmiştir. Gereç ve Yöntemler: Bu çalışma Selçuk Üniversitesi Diş Hekimliği Fakültesi’ne başvuran 188 (14-16 yaş arasındaki) okul çağındaki birey üzerinde gerçekleştirildi. Her birey için DMFT (Çürük, Dolgulu ve Eksik Diş Sayısı) indeksi, plak ve gingival indeks değerleri hesaplandı. DMFT indeksi değerlendirmesinde klinik muayenede Dünya Sağlık Örgütü (DSÖ) kriterleri, radyografik değerlendirme de bitewing radyograflari kullanıldı. Bireylerden cinsiyet, yaş, diş hekimi ziyaret sıklığı, ağız bakım alışkanlıkları, anne-baba eğitim düzeyi ve gelir düzeyi konularında sorular içeren anket formunu doldurmaları istendi. Tüm kayıtların alınmasından sonra bireyler diş hekimi ziyaret sıklığına göre düzenli ve düzensiz olmak üzere iki gruba ayrıldı. İstatistik analiz için Chi-square testi kullanıldı. Bulgular: Sonuçlara göre düzenli diş hekimi ziyareti olan birey sayısı 47 iken, 141 bireyin düzensiz gruba girdiği bulundu. Diş hekimi ziyaret sıklığına göre oluşturulan gruplarda ilk diş hekimine gitme yaşı (p < 0.001), çürüklü (p < 0.001) ve dolgulu (p=0,029) diş sayısı ortalaması, plak indeksi (p=0,005), diş fırçalama sıklığı (p=0,004) ve yatmadan önce fırçalama (p=0,013) açısından anlamlı derecede fark olduğu görüldü. Diğer yandan cinsiyet (p=0,308), eksik diş ortalaması (p=0,421), DMFT ortalaması (p=0,183), gingival indeks (p=0,05), diş ipi kullanımı (p=0,101) ve gargara kullanımı (p=0,155), anne (p=0,084) ve babanın (p=0,489) eğitim seviyesi ve gelir düzeyi (p=0,768) açısından ilişki bulunmadı. Sonuç: Düzenli diş hekimi ziyaretlerinin çocukların ağız bakımının desteklenmesi ve genel çürük risklerinin düşürülmesi açısından son derece önem arz ettiği düşünülmektedir

A Multi-Stage Remanufacturing Approach for Life Extension of Safety Critical systems

Life extension of safety critical systems is gaining popularity in many industries due to the increasing demand in world's energy consumption and the strong desire to reduce carbon emissions by different countries. Identification and implementation of a suitable life extension strategy enables safety critical systems to perform their intended functions under stated condition for an extended period of time beyond original design life. In the past, the viability analysis of life extension strategies has been undertaken based on the accumulated knowledge and experience of Original Equipment Manufacturer (OEM), maintenance engineers and inspectors. These approaches involving expert judgement are qualitative in nature and based on conservative assumptions, which may lead to inaccurate conclusion or misleading recommendations to asset managers. Therefore, it is crucial to develop an approach consisting of methods to determine the technical condition of components, estimate the cost of life extension interventions and to analyze carbon footprints. “Remanufacturing” is considered as a suitable end-of-life strategy that can help reduce the overall environmental burden from the product by processing waste materials while at the same time keeping reliability high. Due to the advantages of remanufacturing, it is widely applied for life extension purposes in safety critical industries such as offshore oil and gas, nuclear power, petrochemical, renewable energy, rail transport, aviation, shipping, and electricity distribution and transmission. In this paper, a multi-stage approach is presented to analyze the impact of remanufacturing of safety critical systems on the performance of industrial operations in terms of total cost and carbon footprint. In this approach, the equipment health status is determined by modelling the degradation of the system and then the maintenance costs and carbon footprint are calculated. For the purpose of clarity, the proposed model is applied to an air compressor system and the results are discussed

Assessment of Interest of Healthcare Employees in Distance Training in the Coronavirus Disease-2019 Pandemic Process

Introduction:In-service healthcare personnel training is an ongoing process. However, emerging unknowns require momentary planning. The Coronavirus disease-2019 (COVID-19) pandemic has made distance training (DT) compulsory for healthcare employees (HE). Thus, it is important to learn about their interest levels. This study investigates the interest of HE in DT during the pandemic process.Methods:The research population consisted of 3,442 personnel registered to take the “HE COVID-19” training at research and training hospital in 2020. The population of the study consisted of all personnel employed at research and training hospital and registered for the training. The study was planned retrospectively for reaching all personnel whose training registrations were made between 17.03.2020 and 15.04.2020. This study was used the data of the personnel who completed the “HE COVID-19 Training” within the scope of the announcements that were made as DT as reported on the Hospital Training System.Results:The total training completion rate of the participants was found to be 90%. When the interests of the HE in the DT in the process of the COVID-19 pandemic were compared, no statistically significant difference could be observed in the participation rates of the specialist doctors, resident doctors, and nurses (p=0.094). The rate of the resident doctors to complete the training until the second announcement was significantly lower compared to the specialist doctors and nurses (specialist doctor vs. resident doctor p=0.044; nurse vs. resident doctor p<0.001). The rates of completing the training after two announcements were significantly higher among the resident doctors than the specialist doctors and nurses and among the specialist doctors than the nurses (respectively p=0.018, p<0.001, p=0.018).Conclusion:Continuous training must ensure that HE are adequately prepared to deal with public health emergencies such as the COVID-19 pandemic. DT should be prioritized in the Emergency Action Plan

Is blue light exposure a cause of precocious puberty in male rats?

PurposeOur study aimed to examine the effects of blue light exposure on prepubertal male rats’ puberty and testis tissue.MethodsEighteen 21-day-old male Sprague Dawley rats were divided into three groups consisting of six rats in each group: Control Group (CG), Blue Light-6 hours (BL-6), and Blue Light-12 hours (BL-12). CG rats were maintained with 12/12-hour light-dark cycles. The rats of BL-6 and BL-12 were exposed to blue light (450-470nm/irradiance level 0.03uW/cm2) for 6 hours and 12 hours, respectively. Rats were exposed to blue light until the first signs of puberty. The ELISA method was used to analyze the serum levels of FSH, LH, testosterone, DHEA-S, leptin, ghrelin, melatonin, glutathione, glutathione peroxidase, and malondialdehyde. Testes were dissected for histomorphological examination.ResultsThe medians of the pubertal entry days of the CG, BL-6, and BL-12 were 38th, 30th, and 28th days, respectively. (p:0.001) The FSH, LH, and testosterone concentrations of all groups were similar. The FSH concentration increased as the LH concentration increased (r: 0.82 p: 0.001). The serum LH concentration increased as serum testosterone, and DHEAS decreased, respectively (r: -0.561, p: 0.01) (r:-0.55 p:0.01). Testicular lengths and weights of the BL groups were smaller compared to CG (p: 0.03),(p: 0.04). GPx was higher for BL-6 and BL-12 than the CG (p:0.021, p:0.024). Testis tissue was compatible with the pubertal period in all groups. As the blue light exposure time increased, spermatogenesis was suppressed, and capillary dilatation and edema in the testis tissue increased.ConclusionOur study is the first to show the effects of blue light exposure on male rats’ puberty process. And we showed that exposure to blue light and the duration of exposure lead to precocious puberty in male rats. The blue light exposure suppressed spermatogenesis, marked vasodilatation in the interstitial area of the testis, and disrupted the integrity of the basement membrane. These findings intensified with increasing exposure time

ARAS VE COPRAS YÖNTEMLERİYLE NAKİT AKIŞINA DAYALI PERFORMANS ÖLÇÜMÜ: BIST KİMYA, PETROL, KAUÇUK VE PLASTİK ÜRÜNLER SEKTÖRÜNDE BİR UYGULAMA

Şirketlerin finansal performanslarının ölçülmesinde nakit akışı olarak ifade edilen kaynak yaratma gücü ve nakit kullanımlarına ilişkin bilgilerden yararlanılmaktadır. Geleneksel yöntemlerle yapılan değerlendirmeler dışında finansal performansın değerlendirilmesinde çok kriterli karar verme yöntemlerinin de kullanıldığı görülmektedir. Bu çalışmanın amacı, Borsa İstanbul (BIST) kimya, petrol, kauçuk ve plastik (KPKP) ürünler sektöründeki şirketlerin nakit akış bilgilerine göre ARAS (Additive Ratio Assessment) ve COPRAS (Complex Proportional Assessment) yöntemleriyle sıralamalarını bulmak ve öneriler getirmektir. BIST-KPKP sektöründeki 32 şirketin performans sıralaması için nakit akış bilgilerine dayalı 18 adet oran kriter olarak belirlenmiş, 16 kriterin yüksek ve 2 kriterin düşük değerler olması tercih edilmiştir. ARAS ve COPRAS yöntemlerine göre yapılan sıralamalarda birebir aynı sonuçlar olmasa da yakınsak sonuçlar elde edilmiştir.The aim of this study is to find the ranking of the companies which are listed in Borsa İstanbul (BIST) chemicals, petroleum, rubber and plastic (CPRP) products industry according to their cash flow information with the methods of ARAS (Additive Ratio Assessment) and COPRAS (Complex Proportional Assessment). For the performance ranking of the 32 companies in the BIST-CPRP sector, 18 ratios based on cash flow information were selected as the criterion. Additionally, 16 criterions are selected as high and 2 criterions are selected as low among 18 criterions. The results of ranking with ARAS and COPRAS methods were not identical, but convergent results were obtained