Development of a severe local storm prediction system: A 60-day test of a mesoscale primitive equation model

The progress and problems associated with the dynamical forecast system which was developed to predict severe storms are examined. The meteorological problem of severe convective storm forecasting is reviewed. The cascade hypothesis which forms the theoretical core of the nested grid dynamical numerical modelling system is described. The dynamical and numerical structure of the model used during the 1978 test period is presented and a preliminary description of a proposed multigrid system for future experiments and tests is provided. Six cases from the spring of 1978 are discussed to illustrate the model's performance and its problems. Potential solutions to the problems are examined

Reduced Retinal Microvascular Density, Improved Forepaw Reach, Comparative Microarray and Gene Set Enrichment Analysis with c-jun Targeting DNA Enzyme

Retinal neovascularization is a critical component in the pathogenesis of common ocular disorders that cause blindness, and treatment options are limited. We evaluated the therapeutic effect of a DNA enzyme targeting c-jun mRNA in mice with pre-existing retinal neovascularization. A single injection of Dz13 in a lipid formulation containing N-[1-(2,3-dioleoyloxy)propyl]-N,N,N-trimethylammonium methyl-sulfate and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine inhibited c-Jun expression and reduced retinal microvascular density. The DNAzyme inhibited retinal microvascular density as effectively as VEGF-A antibodies. Comparative microarray and gene expression analysis determined that Dz13 suppressed not only c-jun but a range of growth factors and matrix-degrading enzymes. Dz13 in this formulation inhibited microvascular endothelial cell proliferation, migration and tubule formation in vitro. Moreover, animals treated with Dz13 sensed the top of the cage in a modified forepaw reach model, unlike mice given a DNAzyme with scrambled RNA-binding arms that did not affect c-Jun expression. These findings demonstrate reduction of microvascular density and improvement in forepaw reach in mice administered catalytic DNA.This work was supported by grants from Cancer Institute NSW and the National Health and Medical Research Council (NHMRC). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript

Recent examples of mesoscale numerical forecasts of severe weather events along the east coast

Mesoscale numerical forecasts utilizing the Mesoscale Atmospheric Simulation System (MASS) are documented for two East Coast severe weather events. The two events are the thunderstorm and heavy snow bursts in the Washington, D.C. - Baltimore, MD region on 8 March 1984 and the devastating tornado outbreak across North and South Carolina on 28 March 1984. The forecasts are presented to demonstrate the ability of the model to simulate dynamical interactions and diabatic processes and to note some of the problems encountered when using mesoscale models for day-to-day forecasting

Eigenstate Structure in Graphs and Disordered Lattices

We study wave function structure for quantum graphs in the chaotic and disordered regime, using measures such as the wave function intensity distribution and the inverse participation ratio. The result is much less ergodicity than expected from random matrix theory, even though the spectral statistics are in agreement with random matrix predictions. Instead, analytical calculations based on short-time semiclassical behavior correctly describe the eigenstate structure.Comment: 4 pages, including 2 figure

Little Higgs Model Completed with a Chiral Fermionic Sector

The implementation of the little Higgs mechanism to solve the hierarchy problem provides an interesting guiding principle to build particle physics models beyond the electroweak scale. Most model building works, however, pay not much attention to the fermionic sector. Through a case example, we illustrate how a complete and consistent fermionic sector of the TeV effective field theory may actually be largely dictated by the gauge structure of the model. The completed fermionic sector has specific flavor physics structure, and many phenomenological constraints on the model can thus be obtained beyond gauge, Higgs, and top physics. We take a first look on some of the quark sector constraints.Comment: 14 revtex pages with no figure, largely a re-written version of hep-ph/0307250 with elaboration on flavor sector FCNC constraints; accepted for publication in Phys.Rev.

A New Experiment to Study Hyperon CP Violation and the Charmonium System

Fermilab operates the world's most intense antiproton source, now exclusively dedicated to serving the needs of the Tevatron Collider. The anticipated 2009 shutdown of the Tevatron presents the opportunity for a world-leading low- and medium-energy antiproton program. We summarize the status of the Fermilab antiproton facility and review physics topics for which a future experiment could make the world's best measurements.Comment: 16 pages, 3 figures, to appear in Proceedings of CTP symposium on Supersymmetry at LHC: Theoretical and Experimental Perspectives, The British University in Egypt, Cairo, Egypt, 11-14 March 200

Cosmological Symmetry Breaking, Pseudo-scale invariance, Dark Energy and the Standard Model

The energy density of the universe today may be dominated by the vacuum energy of a slowly rolling scalar field. Making a quantum expansion around such a time dependent solution is found to break fundamental symmetries of quantum field theory. We call this mechanism cosmological symmetry breaking and argue that it is different from the standard phenomenon of spontaneous symmetry breaking. We illustrate this with a toy scalar field theory, whose action displays a U(1) symmetry. We identify a symmetry, called pseudo-scale invariance, which sets the cosmological constant exactly equal to zero, both in classical and quantum theory. This symmetry is also broken cosmologically and leads to a nonzero vacuum or dark energy. The slow roll condition along with the observed value of dark energy leads to a value of the background scalar field of the order of Planck mass. We also consider a U(1) gauge symmetry model. Cosmological symmetry breaking, in this case, leads to a non zero mass for the vector field. We also show that a cosmologically broken pseudo-scale invariance can generate a wide range of masses.Comment: 18 pages, no figure

On Toroidal Horizons in Binary Black Hole Inspirals

We examine the structure of the event horizon for numerical simulations of two black holes that begin in a quasicircular orbit, inspiral, and finally merge. We find that the spatial cross section of the merged event horizon has spherical topology (to the limit of our resolution), despite the expectation that generic binary black hole mergers in the absence of symmetries should result in an event horizon that briefly has a toroidal cross section. Using insight gained from our numerical simulations, we investigate how the choice of time slicing affects both the spatial cross section of the event horizon and the locus of points at which generators of the event horizon cross. To ensure the robustness of our conclusions, our results are checked at multiple numerical resolutions. 3D visualization data for these resolutions are available for public access online. We find that the structure of the horizon generators in our simulations is consistent with expectations, and the lack of toroidal horizons in our simulations is due to our choice of time slicing.Comment: Submitted to Phys. Rev.

Localization of Eigenfunctions in the Stadium Billiard

We present a systematic survey of scarring and symmetry effects in the stadium billiard. The localization of individual eigenfunctions in Husimi phase space is studied first, and it is demonstrated that on average there is more localization than can be accounted for on the basis of random-matrix theory, even after removal of bouncing-ball states and visible scars. A major point of the paper is that symmetry considerations, including parity and time-reversal symmetries, enter to influence the total amount of localization. The properties of the local density of states spectrum are also investigated, as a function of phase space location. Aside from the bouncing-ball region of phase space, excess localization of the spectrum is found on short periodic orbits and along certain symmetry-related lines; the origin of all these sources of localization is discussed quantitatively and comparison is made with analytical predictions. Scarring is observed to be present in all the energy ranges considered. In light of these results the excess localization in individual eigenstates is interpreted as being primarily due to symmetry effects; another source of excess localization, scarring by multiple unstable periodic orbits, is smaller by a factor of $\sqrt{\hbar}$.Comment: 31 pages, including 10 figure