TEM analysis and comparison on the BDC using several reanalysis data sets

第3回極域科学シンポジウム　横断セッション「中層大気・熱圏」 11月26日（月） 国立極地研究所 ２階大会議

Therapeutic effect of hyperthermia combined with chemotherapy on vulvar and vaginal carcinoma.

A clinical trial was performed to investigate the efficacy of hyperthermia in combination with chemotherapy for gynecological malignancies. Sixty-nine patients with vaginal or vulvar malignancies (9 primary vulvar, 3 recurrent vulvar, 11 primary vaginal, 4 primary cervical, 40 recurrent cervical, and 2 recurrent ovarian carcinomas) were treated by thermochemotherapy (42 cases) or chemotherapy alone (27 cases). After treatment, 7 patients underwent surgery and 46 patients irradiation. The chemotherapeutic schedule was mainly a combination therapy with bleomycin and mitomycin C (B-M). Microwaves of 2.45 GHz were applied to induce local hyperthermia. The side effects of chemotherapy were not increased by hyperthermia. The rate of partial response plus complete response increased to 84% (16/19) in primary cancers and 45% in recurrent cancers by hyperthermia, compared to the respective values of 40% (2/5) and 17% (3/17) for chemotherapy alone. However, a satisfactory prognosis cannot be expected with thermochemotherapy, unless additional treatments are performed. Subsequent surgery or radiation treatment improved the progression-free interval.</p

Postural muscle activity patterns during standing at rest and on an oscillating floor

金沢大学大学院医学系研究科環境社会医学Postural muscle activity pattern was examined in the eyes-closed state after adequate adaptation to floor anteroposterior oscillation. Twenty-three subjects were grouped almost evenly according to dominance of anterior or posterior postural muscles in the trunk and thigh during quiet stance. In the posterior-dominant group, this dominance was maintained at every frequency in most subjects. In the anterior-dominant group, this dominance was maintained in most subjects at 0.1 and 0.5 Hz but changed to posterior dominance at 1.0 and 1.5 Hz in about half the subjects. Periodicity of muscle activity was evaluated by EMG amplitude spectrum at the floor oscillation frequency. Periodicity of posterior-dominant muscles in the trunk and thigh increased with increasing oscillatory frequency. In the trunk, the periodicity did not differ significantly between posterior-dominant and anterior-dominant groups. However, in the thigh, periodicity was significantly lower in the anterior-dominant muscles. This was considered to be caused by nonperiodic alternating action of the anterior and posterior muscles. In the lower leg, posterior dominance was observed in quiet stance and at all oscillation frequencies. Periodicity of soleus and gastrocnemius increased at higher frequencies and was higher in gastrocnemius than in soleus. The periodicity difference between both muscles decreased with increasing oscillation frequency. © 2005 Elsevier Ltd. All rights reserved

日本人の糖尿病と微量元素に関する栄養学的研究

糖尿病外来患者87名を村象として,罹病期間・合併症発症の危険因子となる肥満・禁煙・飲酒,主な3大合併症である腎症・神経症・網膜症の分類による臨床検査所見の変動を比較した。(1)罹病期間が長くなるに従って,血糖コントロールは悪化し,マグネシウムも同様に減少がみられた。(2)肥満になるにつれ,血糖コントロールは不良となり,HDLコレステロールやマグネシウムも減少傾向を示した。(3)喫煙者に血糖コントロール不良が多くみられ,マグネシウムは非喫煙者よりも低値であった。(4)FBSでは毎日飲酒する群が最も高く1.5AGも同様に悪い結果を示し,HbA_は飲酒による変動はみられなかった。(5)腎症,単純網膜症,増殖性網膜症,神経症を併発した群はFBS,HbA_は,もたない群に対して高値であるため,コントロールが良好でないことが示された。さらに,血中マグネシウムは低値を示した。(6)骨減少症とうつ病を合併している群においても血中マグネシウム量の減少が見られた。(7)マグネシウム摂取量を計算した。最初に穀類中のマグネシウム摂取量の年次推移を計算した。これは穀類中に含まれるマグネシウムの量が圧倒的に多く,これの計算のみでマグネシウム摂取量の年次推移の傾向を知ることができるからである。その結果年を経るとともに,徐々に急速に減少している。最近では日本人の栄養推奨量300mgに不足してきたことが分かる。これらは主に,日本人が穀物を徐々に摂取しなくなったためである。糖尿病の有病者数と死亡者数も年々増加してきている。糖尿病とMgとの関係は大きく,そのため食事によるマグネシウムの摂取は極めて重要なことである。このことからマグネシウムの摂取について国民はもっと注意を払うべきだと考えられた。Diabetes mellitus is a disorder of carbohydrate metabolism characterized by hyperglycemia and glycosuria, and associated with a disturbance of the normal insulin mechanism. Moreover, diabetes mellitus occurs more often in patients with cardiovascular disease, arteriosclerosis, diabetic nephrosis, diabetic retinopathy, necrosis of lower limbs and at least the patients died from these complications. In Japan, a prevalence rate of diabetes was very low in 1920\u27s. But recently, its patients are increasing with satiation and unbalance of food intakes. The purpose of this research is to clarify the relationship between increasing diabetes mellitus and their food habits. For this reason, we examined the physical and nutritional status of about 100 diabetic patients and analyzed the relationship between their clinical findings and food habits. Eighty-seven of diabetic outpatients were examined clinically in relation to duration of disease and complications. The control of blood sugar in diabetic patients with complications were dull, and their blood magnesium levels were also deteriorated. The levels of HbA_, and 1.5AG in patients with diabetic nephropathy were high, and the blood magnesium level was low. In Japan, the consumption of rice as a staple food has declined sharply, from 358g/day in 1960 to only 216g/day in 1985, resulting in a low intake of magnesium. On the contrary, the intakes of animal foods such as milk and dairy products, egg and meat, are markedly increased. Changes of magnesium contents from cereals are decreased about half of 40 years ago. Changes in morbidity and mortality rates from diabetes mellitus were compared with changes of magnesium intake. The mortality rates increased about 10 times in past 40 years, and magnesium intake also decreased about half in past 40 years. This result suggests that increased magnesium intakes play an important role in prevention of diabetes mellitus