Region specificity of rectus femoris muscle for force vectors in vivo.

To examine the region specificity within the rectus femoris (RF) for knee extension and hip flexion force directions, three force components around the ankle were measured during intramuscular electrical stimulation applied to six parts of the RF: a proximal and medial part, a proximal and lateral part, a middle and medial part, a middle and lateral part, a distal and medial part, and a distal and lateral part. As a result, the exerted force directions in all of the subjects were variable in all regions, and the proximal region of the RF was the dominant contributor to the hip flexion moment. In addition, the force in the lateral region of the RF, rather than that in the medial region, denoted the lateral direction. These results suggest that divergent regions of muscle fibers within the RF are responsible for different functions in determining the force direction

ヴィーガニズムとリレーショナル・アート : 人間・食物・自然関係と新たな芸術的表現

多摩美術大学201

Observations of Sunspot Oscillations in G band and Ca II H line with Solar Optical Telescope on Hinode

Exploiting high-resolution observations made by the Solar Optical Telescope onboard Hinode, we investigate the spatial distribution of power spectral density of oscillatory signal in and around NOAA active region 10935. The G-band data show that in the umbra the oscillatory power is suppressed in all frequency ranges. On the other hand, in Ca II H intensity maps oscillations in the umbra, so-called umbral flashes, are clearly seen with the power peaking around 5.5 mHz. The Ca II H power distribution shows the enhanced elements with the spatial scale of the umbral flashes over most of the umbra but there is a region with suppressed power at the center of the umbra. The origin and property of this node-like feature remain unexplained.Comment: 7 pages, 8 figures, accepted for publication in PASJ (Hinode Special Issue

BMP2-induced gene profiling in dental epithelial cell line

Tooth development is regulated by epithelial-mesenchymal interactions and their reciprocal molecular signaling. Bone morphogenetic protein 2 (BMP2) is known as one of the inducers for tooth development. To analyze the molecular mechanisms of BMP2 on ameloblast differentiation (amelogenesis), we performed microarray analyses using rat dental epithelial cell line, HAT-7. After confirming that BMP2 could activate the canonical BMP-Smads signaling in HAT-7 cells, we analyzed the effects of BMP2 on 14,815 gene expressions and profiled them. Seventy-three genes were up-regulated and 28 genes were down-regulated by BMP2 treatment for 24 hours in HAT-7 cells. Functional classification revealed that 18% of up-regulated genes were ECM/adhesion molecules present in the enamel organ. Furthermore, we examined the expression of several differentiation markers in dental epithelial four cell-lineages including inner enamel epithelium (ameloblasts), stratum intermedium, stratum reticulum, and outer enamel epithelium. The results indicated that BMP2 might induce at least two different cell-lineage markers including a BMP antagonist expressed in HAT-7 cells, suggesting that BMP2 could accelerate amelogenesis via BMP signaling

理科指導法における模擬授業の実践と評価

本研究の目的は，理科指導法における模擬授業の実践を通して，学生が授業観察の視点を深めることができたかどうかを 明らかにすることである。その目的を達成するために模擬授業後の学生によるコメントの分析と，全ての模擬授業が終了し た後の学生の振り返りの記述の分析を行なった。その結果，次の二つのことが分かった。 (1) 模擬授業を行うことで教師の振る舞いについて指摘する数は減り，教授について指摘する割合が顕著に増加した。小 学校教育全般に対する指摘は減少し，理科授業全般や単元固有のことについて指摘する数が増加した。 (2) 模擬授業を通して，理科の授業ができるポイントを見つけることができたと評価する学生は99 パーセントに達した。 理科の指導がうまくなったと評価する学生は半数を超えた

Seaweed intake and blood pressure levels in healthy pre-school Japanese children

<p>Abstract</p> <p>Background</p> <p>Few studies have examined whether dietary factors might affect blood pressure in children. We purposed to investigate whether seaweed intake is associated with blood pressure level among Japanese preschool children.</p> <p>Methods</p> <p>The design of the study was cross-sectional and it was conducted in autumn 2006. Subjects were healthy preschoolers aged 3-6 years in Aichi, Japan. Blood pressure and pulse were measured once by an automated sphygmomanometer, which uses oscillometric methods. Dietary data, including seaweed intake, were assessed using 3-day dietary records covering 2 consecutive weekdays and 1 weekend day. Of a total of 533 children, 459 (86.1 percent) agreed to be enrolled in our study. Finally, blood pressure measurement, complete dietary records and parent-reported height and weight were obtained for 223 boys and 194 girls.</p> <p>Results</p> <p>When we examined Spearman's correlation coefficients, seaweed intake was significantly negatively related to systolic blood pressure in girls (<it>P </it>= 0.008). In the one-way analysis of covariance for blood pressure and pulse after adjustments for age and BMI, the boys with the lowest, middle and highest tertiles of seaweed intake had diastolic blood pressure readings of 62.8, 59.3 and 59.6 mmHg, respectively (<it>P </it>= 0.11, trend <it>P </it>= 0.038). Girls with higher seaweed intake had significantly lower systolic blood pressure readings (102.4, 99.2 and 96.9 mmHg for girls with the lowest, middle and highest tertiles of seaweed intake, respectively; <it>P </it>= 0.037, trend <it>P </it>= 0.030).</p> <p>Conclusion</p> <p>Our study showed that seaweed intake was negatively related to diastolic blood pressure in boys and to systolic blood pressure in girls. This suggests that seaweed might have beneficial effects on blood pressure among children.</p

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant

SARS-CoV-2オミクロンBA.2.75株（通称ケンタウロス）のウイルス学的性状の解明. 京都大学プレスリリース. 2022-10-12.The SARS-CoV-2 Omicron BA.2.75 variant emerged in May 2022. BA.2.75 is a BA.2 descendant but is phylogenetically distinct from BA.5, the currently predominant BA.2 descendant. Here, we show that BA.2.75 has a greater effective reproduction number and different immunogenicity profile than BA.5. We determined the sensitivity of BA.2.75 to vaccinee and convalescent sera as well as a panel of clinically available antiviral drugs and antibodies. Antiviral drugs largely retained potency but antibody sensitivity varied depending on several key BA.2.75-specific substitutions. The BA.2.75 spike exhibited a profoundly higher affinity for its human receptor, ACE2. Additionally, the fusogenicity, growth efficiency in human alveolar epithelial cells, and intrinsic pathogenicity in hamsters of BA.2.75 were greater than those of BA.2. Our multilevel investigations suggest that BA.2.75 acquired virological properties independent of BA.5, and the potential risk of BA.2.75 to global health is greater than that of BA.5