Pre-seismic ionospheric anomalies detected before the 2016 Taiwan earthquake

On Feb. 5 2016 (UTC), an earthquake with moment magnitude 6.4 occurred in southern Taiwan, known as the 2016 (Southern) Taiwan earthquake. In this study, evidences of seismic earthquake precursors for this earthquake event are investigated. Results show that ionospheric anomalies in Total Electric Content (TEC) can be observed before the earthquake. These anomalies were obtained by processing TEC data, where such TEC data are calculated from phase delays of signals observed at densely arranged ground-based stations in Taiwan for Global Navigation Satellite Systems. This shows that such anomalies were detected within 1 hour before the event

Capability of TEC correlation Analysis and Deceleration at Propagation Velocities of Medium-Scale Traveling Ionospheric Disturbances: Preseismic Anomalies before the Large Earthquakes

Data analysis method (CRA, hereafter) to correlate multiple TEC anomaly signals has detected pre-seismic anomalies before the 2011 Tohoku-Oki earthquake (Iwata & Umeno 2016), the 2016 Kumamoto earthquake (Iwata & Umeno 2017) and the 2016 Tainan earthquake (Goto et al. 2019). However, a critical argument said that those anomalies detected by CRA would not be pre-seismic anomalies published by Journal of Geophysical Research-Space Physics (126), 2021 (JGR-SP (126), hereafter). In this paper, we would point out its incorrect use of statistical anomalies in evaluating CRA as the following points: CRA is shown to increase the signal-to-noise ratio (SNR) to amplify pre-seismic TEC’s small anomaly signals with synchronizing and correlating multiple GNSS receivers’ data. We proved again that pre-seismic anomalies certainly exist before the 2011 Tohoku-Oki earthquake and the 2016 Kumamoto earthquake with additional data analysis. In particular, as a temporal anomaly, deceleration at propagation velocities of medium-scale traveling ionospheric disturbances (MSTID, hereafter) before the 2016 Kumamoto earthquake captured by CRA (Iwata & Umeno 2017) is elucidated as pre-seismic anomalies. Furthermore, we proposed a physical model to predict that 35 m/s change at MSTID propagation velocities estimated by TEC’s CRA requires 0.58 × 10⁻³ V/m electric field in the F Layer ionosphere. Contrary to the claim with the incorrect use of statistical anomalies in JGR-SP (126), TEC’s correlation anomalies detected by CRA (Iwata & Umeno 2016 and Iwata & Umeno 2017) clearly provided supporting evidence that physical pre-seismic anomalies really exist

Synergistic inhibition of pro-inflammatory pathways by ginger and turmeric extracts in RAW 264.7 cells

Synergy plays a prominent role in herbal medicines to increase potency and widen the therapeutic windows. The mechanism of synergy in herbal medicines is often associated with multi-targeted behavior and complex signaling pathways which are challenging to elucidate. This study aims to investigate the synergistic mechanism of a combination (GT) of ginger (G) and turmeric (T) extracts by exploring the modulatory activity in lipopolysaccharides (LPS)-induced inflammatory pathways and key molecular targets. A Bioplex ProTM mouse cytokine 23-plex assay was utilized to assess the broad anti-cytokine activity of GT in LPS and interferon (IFN)-gamma (both at 50 ng/mL)-activated RAW 264.7 cells. The inhibitory effects of individual and combined G and T on major proinflammatory mediators including nitric oxide (NO), tumor necrosis factor (TNF) and interleukin (IL)-6 were tested using Griess reagents and ELISA assays, respectively. Immunofluorescent staining and Western blot were used to investigate the modulatory effect of GT on key proteins in the LPS/TLR4 signaling transduction. The regulation of murine microRNA miR-155-5p was tested using real-time PCR. The IC50 value and combination index (CI) values were used to demonstrate potency and synergistic interaction, respectively. GT synergistically attenuated a range of pro-inflammatory mediators including inducible NO, major cytokines (TNF and IL-6) and secondary inflammatory cytokines (GM-CSF and MCP-1). GT significantly inhibited LPS-induced NF-kB p65 translocation, the activation of TLR4, TRAF6, and phosphorylation of JNK and c-JUN. Moreover, the suppressive effect of GT on each of the protein targets in this axis was stronger than that of the individual components. Real-time PCR analysis showed that GT suppressed miR-155-5p to a greater extent than G or T alone in LPS-stimulated cells. Our study demonstrates the synergistic mechanism of GT in downregulating LPS-induced proinflammatory pathways at the miRNA and protein levels. Our results establish a scientific basis for the combined application of G and T as an advanced therapeutic candidate in inflammatory diseases with broad and synergistic anti-inflammatory activity and multi-targeted mechanisms

Model-based engine fault detection using cylinder pressure estimates from nonlinear observers

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Improved optical limiting performance of laser-ablation-generated metal nanoparticles due to silica-microsphere-induced local field enhancement

For practical application, optical limiting materials must exhibit a fast response and a low threshold in order to be used for the protection of the human eye and electro-optical sensors against intense light. Many nanomaterials have been found to exhibit optical limiting properties. Laser ablation offers the possibility of fabricating nanoparticles from a wide range of target materials. For practical use of these materials, their optical limiting performance, including optical limiting threshold and the ability to efficiently attenuate high intensity light, needs to be improved. In this paper, we fabricate nanoparticles of different metals by laser ablation in liquid. We study the optical nonlinear properties of the laser-generated nanoparticle dispersion. Silica microspheres are used to enhance the optical limiting performance of the nanoparticle dispersion. The change in the optical nonlinear properties of the laser-generated nanoparticle dispersion caused by silica microspheres is studied. It is found that the incident laser beam is locally focused by the microspheres, leading to an increased optical nonlinearity of the nanoparticle dispersion

Pre-seismic ionospheric anomalies detected before the 2016 Taiwan earthquake

Corresponding Author : Ken UmenoShin‐itiro Goto, Ryoma Uchida, Kiyoshi Igarashi, Chia‐Hung Chen, Minghui Kao and Ken Umeno (2019). Pre‐seismic ionospheric anomalies detected before the 2016 Taiwan earthquake. Journal of Geophysical Research: Space Physics. https://doi.org/10.1029/2019JA02664

Tuning Optical Nonlinearity of Laser-Ablation-Synthesized Silicon Nanoparticles via Doping Concentration

Silicon nanoparticles at different doping concentrations are investigated for tuning their optical nonlinear performance. The silicon nanoparticles are synthesized from doped silicon wafers by pulsed laser ablation. Their dispersions in water are studied for both nonlinear absorption and nonlinear refraction properties. It is found that the optical nonlinear performance can be modified by the doping concentration. Nanoparticles at a higher doping concentration exhibit better saturable absorption performance for femtosecond laser pulse, which is ascribed to the free carrier absorption mechanism

6-shogaol and 10-shogaol synergize curcumin in ameliorating proinflammatory mediators via the modulation of TLR4/TRAF6/MAPK and NFkB translocation

Extensive research supported the therapeutic potential of curcumin, a naturally occurring compound, as a promising cytokinesuppressive anti-inflammatory drug. This study aimed to investigate the synergistic anti-inflammatory and anti-cytokine activities by combining 6-shogaol and 10-shogaol to curcumin, and associated mechanisms in modulating lipopolysaccharides and interferon-ɣ-induced proinflammatory signaling pathways. Our results showed that the combination of 6-shogaol-10-shogaolcurcumin synergistically reduced the production of nitric oxide, inducible nitric oxide synthase, tumor necrosis factor and interlukin-6 in lipopolysaccharides and interferon-γ-induced RAW 264.7 and THP-1 cells assessed by the combination index model. 6-shogaol-10-shogaol-curcumin also showed greater inhibition of cytokine profiling compared to that of 6-shogaol-10-shogaol or curcumin alone. The synergistic anti-inflammatory activity was associated with supressed NFκB translocation and downregulated TLR4-TRAF6-MAPK signaling pathway. In addition, SC also inhibited microRNA-155 expression which may be relevant to the inhibited NFκB translocation. Although 6-shogaol-10-shogaol-curcumin synergistically increased Nrf2 activity, the anti-inflammatory mechanism appeared to be independent from the induction of Nrf2. 6-shogaol-10-shogaol-curcumin provides a more potent therapeutic agent than curcumin alone in synergistically inhibiting lipopolysaccharides and interferon-γ induced proinflammatory mediators and cytokine array in macrophages. The action was mediated by the downregulation of TLR4/TRAF6/MAPK pathway and NFκB translocation