microRNA-875-5p plays critical role for mesenchymal condensation in epithelial-mesenchymal interaction during tooth development

Epithelial-mesenchymal interaction has critical roles for organ development including teeth, during which epithelial thickening and mesenchymal condensation are initiated by precise regulation of the signaling pathway. In teeth, neural crest-derived mesenchymal cells expressed PDGF receptors migrate and become condensed toward invaginated epithelium. To identify the molecular mechanism of this interaction, we explored the specific transcriptional start sites (TSSs) of tooth organs using cap analysis of gene expression (CAGE). We identified a tooth specific TSS detected in the chromosome 15qD1 region, which codes microRNA-875 (mir875). MiR875-5p is specifically expressed in dental mesenchyme during the early stage of tooth development. Furthermore, PRRX1/2 binds to the mir875 promoter region and enhances the expression of mir875. To assess the role of miR875-5p in dental mesenchyme, we transfected mimic miR875-5p into mouse dental pulp (mDP) cells, which showed that cell migration toward dental epithelial cells was significantly induced by miR875-5p via the PDGF signaling pathway. Those results also demonstrated that miR875-5p induces cell migration by inhibiting PTEN and STAT1, which are regulated by miR875-5p as part of post-transcriptional regulation. Together, our findings indicate that tooth specific miR875-5p has important roles in cell condensation of mesenchymal cells around invaginated dental epithelium and induction of epithelial-mesenchymal interaction

Remarks on Tanimura's reformulation of general relativistic version of Feynman's proof about Maxwell equations

この論文は国立情報学研究所の電子図書館事業により電子化されました。研究会報告We reformulate the genaral relativistic version given by S.Tanimura of Feynman's consideration. Velocity and momentum of a point particle are assumed to be transformed as (contravariant and covariant) vectors under the point transformation in quantum mechanical sense. Such an assumption restricts strongly the equation of motion allowed by the basic commutation relations. This equation is equivalent to Hamilton-type one including scalar, vector and gravitational fields covariantly

Generalization of geometry-induced effect noted by Takagi and Tanzawa

この論文は国立情報学研究所の電子図書館事業により電子化されました。研究会報告The formulation on a particle motion in n-demensional curved manifold M_n embedded in p-dimensional Euclidean space R_p is summarized, and the geometry-induced gauge structure is explained. Next we examine the scalar field theory with a soliton solution, and point out that in spite of the infinite degrees of freedom such a field theory has the same mathematical structure as a particle motion in M_n ⊂ R_p, and our formalism affords a clearer view of understanding physical contents of such a field theory

Study on Nonradiative Decay Process including the Isomerization of p-Methoxy Methyl Cinnamate

第7回分子科学討論会, 2013年9月24日-27日, 京都テルサ(京都), 3A1

Effects of substitution and hydrogen-bonding on nonradiative decay process of Methyl Cinnamate

第8回分子科学討論会, 2014年9月21日-24日, 広島大学東広島キャンパス(東広島), 1P01