siRNA inhibition of JNK II inhibits gp120 induced TRAIL R2 upregulation.

<p>Huh7 cells were treated with either BSA or gp120 in the presence or absence siRNA constructs for JNK I, JNK II, and p38; and analyzed for TRAIL R2 content (A). The results presented below are pooled TRAIL R2 densitometry normalized to Actin. Parallel experiments demonstrate that siRNA for JNK I, JNK II, and p38 did not alter TRAIL R2 expression (B), and these siRNA constructs were specific for the proteins against which they were directed (C).</p

Role of TRAIL in HIV/HCV co-infection.

<p>Schematic model of synergy between HIV gp120/CXCR4-induced TRAIL sensitivity and other proapoptotic stimuli (e.g., HBV, HCV, Bile salts), causing hepatocyte death and consequent cirrhosis.</p