POTENTIAL HYPOGLYCEMIC EFFECT OF ESSENTIAL OIL OF CITRUS RETICULATA IN WISTAR RATS

ABSTRACT The essential oil of Citrus reticulata is reported to have antidiabetic activity, but there are no reports on their interaction with commonly used hypoglycemic agent like glibenclamide. The present study was planned to elucidate hypoglycemic effect of essential oil of Citrus reticulata (ECR) and its interaction with glibenclamide in euglycemic and hyperglycemic rats. Euglycemic and alloxan induced hyperglycemic male Wistar rats were orally administered, the essential oil, glibenclamide (0.9mg/kg), subhypoglycemic dose (SHD) of ECR and SHD of glibenclamide (0.45mg/kg) in single dose separately in different groups blood glucose was estimated using glucometer at 0, 2, 4, 6, 8 and 12hrs. The essential oil of Citrus reticulata exhibited significant hypoglycemic activity, while it did not potentiate the hypoglycemic activity of glibenclamide

Comparative evaluation of the hemodynamic effects of inclusion versus exclusion of dexmedetomidine to pregabalin and fentanyl premedication regimen during airway instrumentation in laparoscopic abdominal surgeries

Background: Airway instrumentation leads to an aggravated hemodynamic response due to increased sympathetic activity, imposing a risk of myocardial ischemia. A premedication regimen using fentanyl and pregabalin blunts the pressure response but not the rate response. Objective: To compare the effects of pregabalin and fentanyl regimen versus pregabalin, fentanyl, and dexmedetomidine regimen on the hemodynamic pressor response during airway instrumentation in laparoscopic abdominal surgery (LAS). Methods: Sixty patients (ASA I and II), undergoing elective LASunder general anesthesia, were randomly divided into 2 groups - Group A (n=30) premedicated with oral pregabalin (150mg) and IV fentanyl (2μg/kg) and Group B (n=30) premedicated with IV dexmedetomidine (0.25μg/kg) in addition to pregabalin-fentanyl regimen. Both groups were managed with the same anesthetic protocol. The preoperative sedation level was assessed before induction. The heart rate (HR), systolic and diastolic BP (SBP, DBP), and mean arterial pressure (MAP) were recorded at baseline as well as preoperatively, prior to intubation and at 1, 3, 5, 10, and 15 min after intubation. Results: Both groups had similar distribution of age, weight, gender, physical status, sedation level as well as intra-operative fentanyl and postoperative analgesic requirements.&nbsp

Comparative Evaluation of the Hemodynamic Effects of Inclusion Versus Exclusion of Dexmedetomidine to Pregabalin and Fentanyl Premedication Regimen During Airway Instrumentation in Laparoscopic Abdominal Surgeries

Background: Airway instrumentation leads to an aggravated hemodynamic response due to increased sympathetic activity, imposing a risk of myocardial ischemia. A premedication regimen using fentanyl and pregabalin blunts the pressure response but not the rate response. Objective: To compare the effects of pregabalin and fentanyl regimen versus pregabalin, fentanyl, and dexmedetomidine regimen on the hemodynamic pressor response during airway instrumentation in laparoscopic abdominal surgery (LAS). Methods: Sixty patients (ASA I and II), undergoing elective LASunder general anesthesia, were randomly divided into 2 groups - Group A (n=30) premedicated with oral pregabalin (150mg) and IV fentanyl (2μg/kg) and Group B (n=30) premedicated with IV dexmedetomidine (0.25μg/kg) in addition to pregabalin-fentanyl regimen. Both groups were managed with the same anesthetic protocol. The preoperative sedation level was assessed before induction. The heart rate (HR), systolic and diastolic BP (SBP, DBP), and mean arterial pressure (MAP) were recorded at baseline as well as preoperatively, prior to intubation and at 1, 3, 5, 10, and 15 min after intubation. Results: Both groups had similar distribution of age, weight, gender, physical status, sedation level as well as intra-operative fentanyl and postoperative analgesic requirements.&nbsp