10 research outputs found

    Recent Developments in Recommender Systems: A Survey

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    In this technical survey, we comprehensively summarize the latest advancements in the field of recommender systems. The objective of this study is to provide an overview of the current state-of-the-art in the field and highlight the latest trends in the development of recommender systems. The study starts with a comprehensive summary of the main taxonomy of recommender systems, including personalized and group recommender systems, and then delves into the category of knowledge-based recommender systems. In addition, the survey analyzes the robustness, data bias, and fairness issues in recommender systems, summarizing the evaluation metrics used to assess the performance of these systems. Finally, the study provides insights into the latest trends in the development of recommender systems and highlights the new directions for future research in the field

    An unambiguous and robust formulation for Wannier localization

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    We provide a new variational definition for the spread of an orbital under periodic boundary conditions (PBCs) that is continuous with respect to the gauge, consistent in the thermodynamic limit, well-suited to diffuse orbitals, and systematically adaptable to schemes computing localized Wannier functions. Existing definitions do not satisfy all these desiderata, partly because they depend on an "orbital center"-an ill-defined concept under PBCs. Based on this theoretical development, we showcase a robust and efficient (10x-70x fewer iterations) localization scheme across a range of materials.Comment: 11 pages, 6 figure

    Leukocyte telomere length and mitochondrial DNA copy number associate with endothelial function in aging-related cardiovascular disease

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    BackgroundWe investigated the association between leukocyte telomere length, mitochondrial DNA copy number, and endothelial function in patients with aging-related cardiovascular disease (CVD).MethodsIn total 430 patients with CVD and healthy persons were enrolled in the current study. Peripheral blood was drawn by routine venipuncture procedure. Plasma and peripheral blood mononuclear cells (PBMCs) were collected. Cell-free genomic DNA (cfDNA) and leukocytic genomic DNA (leuDNA) were extracted from plasma and PBMCs, respectively. Relative telomere length (TL) and mitochondrial DNA copy number (mtDNA-CN) were analyzed using quantitative polymerase chain reaction. Endothelial function was evaluated by measuring flow-mediated dilation (FMD). The correlation between TL of cfDNA (cf-TL), mtDNA-CN of cfDNA (cf-mtDNA), TL of leuDNA (leu-TL), mtDNA-CN of leuDNA (leu-mtDNA), age, and FMD were analyzed based on Spearman's rank correlation. The association between cf-TL, cf-mtDNA, leu-TL, leu-mtDNA, age, gender, and FMD were explored using multiple linear regression analysis.Resultscf-TL positively correlated with cf-mtDNA (r = 0.1834, P = 0.0273), and leu-TL positively correlated with leu-mtDNA (r = 0.1244, P = 0.0109). In addition, both leu-TL (r = 0.1489, P = 0.0022) and leu-mtDNA (r = 0.1929, P < 0.0001) positively correlated with FMD. In a multiple linear regression analysis model, both leu-TL (β = 0.229, P = 0.002) and leu-mtDNA (β = 0.198, P = 0.008) were positively associated with FMD. In contrast, age was inversely associated with FMD (β = −0.426, P < 0.0001).ConclusionTL positively correlates mtDNA-CN in both cfDNA and leuDNA. leu-TL and leu-mtDNA can be regarded as novel biomarkers of endothelial dysfunction

    A new architecture of neural network for fine-grained video analysis based on visual attention

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    Based on a subtle gesture video dataset,a deep network was proposed to improve the performance on such fine-grained actions in this paper.The architecture consisted of a smaller variation of convolutional 3-dimensional (C3D) network and a long short-term memory (LSTM) with a soft attention mechanism.The depth of C3D network and the weight penalty of the attention mechanism were optimized.Experimental results showed that the fine-grained action recognition network could effectively focus on the certain part with important information,and performed better on both average accuracy and detection accuracy for the dataset

    Induction of deformation twinning by dynamic strain aging effect: Rate-temperature coupling effect and constitutive modeling

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    This study focuses on the rate-temperature dependence analysis and constitutive modeling of the DSA-induced deformation twinning, which is a new plastic deformation mechanism discovered in several low-stacking-fault-energy metallic materials. Two types of deformation twinning, namely primary deformation twinning and DSA-induced deformation twinning, were noticed during the plastic deformation of the commercially pure titanium (CP-Ti). The strain, temperature, and strain rate ranges of the DSA-induced deformation twinning, as well as its rate-temperature coupling dependence, were systematically analyzed. The DSA-induced deformation twinning becomes more pronounced with the increasing strain rate and thereby plays a more significant role in enhancing the strain hardening rate than the primary deformation twinning. According to the dynamic Hall-Petch effect of the deformation twinning, a thermo-viscoplastic constitutive model based on the microstruc-tural evolution and the thermal activation theory was developed. The volume fraction of the deformation twins during plastic deformation was expressed as a function of strain, temperature, and strain rate. The developed model was shown to be able to describe the S-shaped true stress vs. true strain curves over the wide ranges of temperature (77-998 K) and strain rate (0.001-8000/s). Finally, considering the interaction between the DSA and deformation twinning, the authors proposed the synergistic strengthening & toughening effect of DSA and deformation twinning, which was believed as a promising mechanism to achieve the simultaneous strengthening and toughing of the metallic materials

    Effect of ACEI and ARB treatment on nitric oxide-dependentendothelial function

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    <jats:p>Summary: Background: Angiotensin-converting-enzyme inhibitors (ACEI) and angiotensin II receptor blockers (ARB) are widely used as a first-line therapy for the treatment of cardiovascular disease. Here, ACEI modulate the bradykinin receptor (BDKRB1 and BDKRB2) system and NO-dependent endothelial function, thus determining cardiovascular health and regenerative arteriogenesis. The current study aims at evaluating nitric oxide-dependent endothelial function, and gene expression of bradykinin receptors in peripheral blood mononuclear cells (PBMC) from patients with ACEI or ARB treatment. Patients and methods: The WalkByLab has been established to screen cardiovascular patients for peripheral artery disease and coronary artery disease. In total 177 patients from WalkByLab with heterogenous disease and risk status were randomly selected, divided according to their medication history into the following groups: 1. ACEI group, 2. ARB group or 3. non-ACE/ARB group. Total plasma nitrite/nitrate (NO) levels were measured, endothelial function was evaluated by assessing flow meditated dilation (FMD). PBMC were isolated from peripheral whole blood, and gene expression (qRT-PCR) of bradykinin receptors and angiotensin converting enzyme were assessed. Results: Plasma total NO concentration in the ACEI group (24.66±16.28, µmol/l) was increased as compared to the ARB group (18.57±11.58, µmol/l, P=0.0046) and non-ACE/ARB group (16.83±8.64, µmol/l, P=0.0127) in patients between 40 to 90 years of age. However, FMD values (%) in the ACEI group (7.07±2.40, %) were similar as compared to the ARB (6.35±2.13, %) and non-ACE/ARB group (6.51±2.15, %), but significantly negatively correlated with age. Interestingly, BDKRB1 mRNA level was significantly higher and BDKRB2 mRNA level lower in the ACEI group (BDKRB1 3.88-fold±1.05, BDKRB2 0.22-fold±0.04) as compared to the non-ACE/ARB group (BDKRB1 1.00-fold±0.39, P<0.0001, BDKRB2 1.00-fold±0.45, P=0.0136). Conclusions: ACEI treatment enhances total nitrite/nitrate concentration, furthermore, upregulates BDKRB1 in PBMC, but downregulates BDKRB2 mRNA expression. FMD is a strong determinant of vascular aging and is sensitive to underlying heterogenous cardiovascular diseases.</jats:p&gt

    Hierarchical fabrication of silica cocoon with hexagonally ordered channel constructed wall via an emulsion-assisted process

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    Silica cocoons are synthesized via a cooperation of hexagonal P123 micelles and O/W emulsions. These silica cocoons are closed on one side but open on another side. The wall of these silica cocoons is hierarchically constructed by hexagonally ordered channels, which is produced by the aggregation of P123 micelles onto the emulsion droplets while the alternating protuberant and hollow wall of these silica cocoons result from a preferential silica condensation around the emulsion droplets. This paper provides a tunable route to synthesis hierarchically constructed nano-sized silica material with 200-500 nm long hexagonally ordered channels, which is determined by the size of the emulsion droplets. (C) 2011 Elsevier Inc. All rights reserved
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