2 research outputs found
Lycibarbarspermidines A–O, New Dicaffeoylspermidine Derivatives from Wolfberry, with Activities against Alzheimer’s Disease and Oxidation
Fifteen new dicaffeoylspermidine
derivatives, lycibarbarspermidines
A–O (<b>1</b>–<b>15</b>), were isolated
from the fruit of Lycium barbarum (wolfberry).
The structures were unambiguously determined by spectroscopic analyses
and chemical methods. Dicaffeoylspermidine derivatives, a rare kind
of plant secondary metabolites, are primarily distributed in the family
of Solanaceae. Only six compounds were structurally identified, and
all of them are acyclic aglycones. Compounds <b>1</b>–<b>15</b> are the first glycosidic products of dicaffeoylspermidine
derivatives, and compounds <b>14</b>–<b>15</b> are
the first cyclization products of dicaffeoylspermidine derivatives.
Moreover, dicaffeoylspermidine derivatives were first isolated and
identified from wolfberry. The short-term memory assay on a transgenic
fly Alzheimer’s disease (AD) model showed that <b>1</b>–<b>15</b> exhibited different levels of anti-AD activity.
The oxygen radical absorbance capacity assay revealed that <b>1</b>–<b>15</b> all displayed antioxidant capacity. Both
anti-AD and antioxidant functions are related to the effects of wolfberry.
Therefore, dicaffeoylspermidine derivatives are considered beneficial
constituents responsible for the antiaging, neuroprotective, anti-AD,
and antioxidant effects of wolfberry
Houttuynoid M, an Anti-HSV Active Houttuynoid from <i>Houttuynia cordata</i> Featuring a Bis-houttuynin Chain Tethered to a Flavonoid Core
Houttuynoid M (<b>1</b>), a
new houttuynoid, and the related
known compound houttuynoid A (<b>2</b>) were isolated from <i>Houttuynia cordata</i>. Their structures were defined using
NMR data analysis, HR-MS<sup><i>n</i></sup> experiment,
and chemical derivatization. Houttuynoid M is the first example of
a houttuynoid with a bis-houttuynin chain tethered to a flavonoid
core. A putative biosynthetic pathway of houttuynoid M (<b>1</b>) is proposed. The anti-herpes simplex virus (anti-HSV) activities
of <b>1</b> and <b>2</b> (IC<sub>50</sub> values of 17.72
and 12.42 μM, respectively) were evaluated using a plaque formation
assay with acyclovir as the positive control