1,225 research outputs found
IgG_{4} Pf NPNA-1 a human anti-Plasmodium falciparum sporozoite monoclonal antibody cloned from a protected individual inhibits parasite invasion of hepatocytes
Malaria is one of the world's most devastating diseases, and Plasmodium falciparum (Pf) causes significant mortalities particularly in Sub-Saharan Africa. The rise and spread of multi-drug resistant strains of the parasite has coincided with an era of increased travel to malaria endemic regions. In the absence of an effective vaccine against malaria it may be possible to utilize human monoclonal antibodies against the stage transmitted by mosquito bites (sporozoites) as a prophylactic to prevent infection. We report the characterization of an engineered human IgG_{4} monoclonal antibody against Pf sporozoite cloned from a protected individual recognized the sporozoite surface and inhibited sporozoite invasion of human hepatocytes in vitro.
The fully human monoclonal antibody PfNPNA-1 IgG_{4} against (NPNA)_{3} specifically labels Plasmodium falciparum in an IFA. This antibody also inhibits Plasmodium falciparum sporozoite invasion of human hepatocytes HepG2-A16 in a dose dependent manner in an in vitro assay. PfNPNA-1 IgG_{4} is a promising candidate for evaluation for the prevention of malaria
A hybrid neuro--wavelet predictor for QoS control and stability
For distributed systems to properly react to peaks of requests, their
adaptation activities would benefit from the estimation of the amount of
requests. This paper proposes a solution to produce a short-term forecast based
on data characterising user behaviour of online services. We use \emph{wavelet
analysis}, providing compression and denoising on the observed time series of
the amount of past user requests; and a \emph{recurrent neural network} trained
with observed data and designed so as to provide well-timed estimations of
future requests. The said ensemble has the ability to predict the amount of
future user requests with a root mean squared error below 0.06\%. Thanks to
prediction, advance resource provision can be performed for the duration of a
request peak and for just the right amount of resources, hence avoiding
over-provisioning and associated costs. Moreover, reliable provision lets users
enjoy a level of availability of services unaffected by load variations
Suppression of Superconducting Critical Current Density by Small Flux Jumps in Thin Films
By doing magnetization measurements during magnetic field sweeps on thin
films of the new superconductor , it is found that in a low temperature
and low field region small flux jumps are taking place. This effect strongly
suppresses the central magnetization peak leading to reduced nominal
superconducting critical current density at low temperatures. A borderline for
this effect to occur is determined on the field-temperature (H-T) phase
diagram. It is suggested that the small size of the flux jumps in films is due
to the higher density of small defects and the relatively easy thermal
diffusion in thin films in comparison with bulk samples.Comment: 7 figures Phys. Rev. B accepted scheduled issue: 01 Feb 200
Observation of nano-indent induced strain fields and dislocation generation in silicon wafers using micro-raman spectroscopy and white beam x-ray topography
In the semiconductor manufacturing industry, wafer handling introduces micro-cracks at the wafer edge. During heat treatment these can produce larger, long-range cracks in the wafer which can cause wafer breakage during manufacture. Two complimentary techniques, micro-Raman spectroscopy (μRS) and White Beam Synchrotron X-ray Topography (WBSXRT) were employed to study both the micro-cracks and the associated strain fields produced by nano-indentations in Si wafers, which were used as a means of introducing controlled strain in the wafers. It is shown that both the spatial lateral and depth distribution of these long range strain fields are relatively isotropic in nature. The Raman spectra suggest the presence of a region under tensile strain beneath the indents, which can indicate a crack beneath the indent and the data strongly suggests that there exists a minimum critical applied load below which cracking will not initiate
Development of KAISTSAT-4 Expanding the Role of Small Satellite for Scientific Research
The fourth Korean small satellite, KAISTSAT-4, is under development by Satellite Technology Research Center (SaTReC) of the Korea Advanced Institute of Science and Technology (KAIST). The KAISTSAT-4 program was commenced on October 1998 with multiple mission objectives, which include exploring space science, deploying satellite-based data collection system and development of precision star sensor. Despite severe constraints on mass and size, these advanced science and engineering payloads are expected to deliver various useful results and exhibit the unique role of small satellite. We present an overview of the KAISTSAT-4 mission and describe its current status. Finally the prospect of future small satellite programs is briefly introduced
Local threshold field for dendritic instability in superconducting MgB2 films
Using magneto-optical imaging the phenomenon of dendritic flux penetration in
superconducting films was studied. Flux dendrites were abruptly formed in a 300
nm thick film of MgB2 by applying a perpendicular magnetic field. Detailed
measurements of flux density distributions show that there exists a local
threshold field controlling the nucleation and termination of the dendritic
growth. At 4 K the local threshold field is close to 12 mT in this sample,
where the critical current density is 10^7 A/cm^2. The dendritic instability in
thin films is believed to be of thermo-magnetic origin, but the existence of a
local threshold field, and its small value are features that distinctly
contrast the thermo-magnetic instability (flux jumps) in bulk superconductors.Comment: 6 pages, 6 figures, submitted to Phys. Rev.
Vertical Confinement and Evolution of Reentrant Insulating Transition in the Fractional Quantum Hall Regime
We have observed an anomalous shift of the high field reentrant insulating
phases in a two-dimensional electron system (2DES) tightly confined within a
narrow GaAs/AlGaAs quantum well. Instead of the well-known transitions into the
high field insulating states centered around , the 2DES confined
within an 80\AA-wide quantum well exhibits the transition at .
Comparably large quantum lifetime of the 2DES in narrow well discounts the
effect of disorder and points to confinement as the primary driving force
behind the evolution of the reentrant transition.Comment: 5 pages, 4 figure
Photoelectron diffraction: from phenomenological demonstration to practical tool
The potential of photoelectron diffraction—exploiting the coherent interference of directly-emitted and elastically scattered components of the photoelectron wavefield emitted from a core level of a surface atom to obtain structural information—was first appreciated in the 1970s. The first demonstrations of the effect were published towards the end of that decade, but the method has now entered the mainstream armoury of surface structure determination. This short review has two objectives: First, to outline the way that the idea emerged and the way this evolved in my own collaboration with Neville Smith and his colleagues at Bell Labs in the early years: Second, to provide some insight into the current state-of-the art in application of (scanned-energy mode) photoelectron diffraction to address two key issue in quantitative surface structure determination, namely, complexity and precision. In this regard a particularly powerful aspect of photoelectron diffraction is its elemental and chemical-state specificity
Scaling Behavior of Anomalous Hall Effect and Longitudinal Nonlinear Response in High-Tc Superconductors
Based on existing theoretical model and by considering our longitudinal
nonlinear response function, we derive a nonliear equation in which the mixed
state Hall resistivity can be expressed as an analytical function of magnetic
field, temperature and applied current. This equation enables one to compare
quantitatively the experimental data with theoretical model. We also find some
new scaling relations of the temperature and field dependency of Hall
resistivity. The comparison between our theoretical curves and experimental
data shows a fair agreement.Comment: 4 pages, 3 figure
Magnetic Fields, Relativistic Particles, and Shock Waves in Cluster Outskirts
It is only now, with low-frequency radio telescopes, long exposures with
high-resolution X-ray satellites and gamma-ray telescopes, that we are
beginning to learn about the physics in the periphery of galaxy clusters. In
the coming years, Sunyaev-Zeldovich telescopes are going to deliver further
great insights into the plasma physics of these special regions in the
Universe. The last years have already shown tremendous progress with detections
of shocks, estimates of magnetic field strengths and constraints on the
particle acceleration efficiency. X-ray observations have revealed shock fronts
in cluster outskirts which have allowed inferences about the microphysical
structure of shocks fronts in such extreme environments. The best indications
for magnetic fields and relativistic particles in cluster outskirts come from
observations of so-called radio relics, which are megaparsec-sized regions of
radio emission from the edges of galaxy clusters. As these are difficult to
detect due to their low surface brightness, only few of these objects are
known. But they have provided unprecedented evidence for the acceleration of
relativistic particles at shock fronts and the existence of muG strength fields
as far out as the virial radius of clusters. In this review we summarise the
observational and theoretical state of our knowledge of magnetic fields,
relativistic particles and shocks in cluster outskirts.Comment: 34 pages, to be published in Space Science Review
- …