Anesthetics disrupt brain development via actions on the mTOR pathway

This work was supported by an ACCM StAAR Award and NIH 1R01GM120519-01 to C.D.M, NARSAD to E.K., a grant from the Chinese Scholarship Council to J.X.Non peer reviewedPublisher PD

Rheb1 mediates DISC1-dependent regulation of new neuron development in the adult hippocampus

Acknowledgments: We thank D. Weinberger, D. St. Clair and D. Valle for discussion, Jaden Shin for gene expression analyses, members of Ming and Song Laboratories for help and critical comments, L. Liu, Y. Cai, Q. Hussaini, and M. Jardine-Alborz for technical support. Funding: This work was supported by NIH (NS048271, MH105128), NARSAD, and MSCRF to G-l.M., by NIH (NS047344 and NS093772) and MSCRF to H.S., by NARSAD and NIH (NS093772) to K.C., and by NARSAD to E.K.Peer reviewedPublisher PD

An Update on Preclinical Research in Anesthetic-Induced Developmental Neurotoxicity in Nonhuman Primate and Rodent Models

Funding Information: Supported by NIH R01GM137213-01 to CDM.Peer reviewedPostprin

Brain-specific Crmp2 deletion leads to neuronal development deficits and behavioural impairments in mice

Acknowledgements: This work was supported by grants from NSF (31430037/31271156/ 31270826) and MOST (2014CB942801/2012CB517904/2012YQ03026006) to Z.X.; from NIH (NS048271, MH105128) to G.-l.M., from NIH (NS047344) to H.S., and from NRASAD to E.K. and K.M.C. Author notes: Hongsheng Zhang, Eunchai Kang and Yaqing Wang: These authors contributed equally to this work.Peer reviewedPublisher PD

Interplay between a Mental Disorder Risk Gene and Developmental Polarity Switch of GABA Action Leads to Excitation-Inhibition Imbalance

Acknowledgments: We thank members of the Ming and Song laboratories for comments and suggestions, D. Johnson for technical support, and J. Schnoll for lab coordination. This work was supported by grants from the National Institutes of Health (NIH) (R01MH105128 and R35NS097370 to G.-L.M. and R37NS047344 to H.S.) and from the National Alliance for Research on Schizophrenia and Depression (NARSAD) to G.-L.M., H.S., and E.K. Author Contributions: E.K. and J.S contributed equally to this work. J.S. performed electrophysiological analysis and E.K. performed morphological analysis. Y.L. and K.-S.H. contributed to electrophysiology data collection, Y.G. and S.G. helped with some of the retrovirus production, and B.B. helped with rabies synaptic tracing. J.P., J.H.L., Q.H., W.L., and K.M.C. contributed to additional data collection. E.K., J.S., H.S., and G-L.M. designed the project and wrote the manuscript.Peer reviewedPublisher PD

Early postnatal exposure to isoflurane causes cognitive deficits and disrupts development of newborn hippocampal neurons via activation of the mTOR pathway

Funding: Johns Hopkins ACCM Department anesthesiology.hopkinsmedicine.org (grant number StAAR) to CDM. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH-NIGMS www.nih.gov (grant number 1R01GM120519-01 and 1K08GM104329-01) to CDM. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH www.nih.gov (grant number NS048271 and MH105128) to GLM. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. NIH www.nih.gov (grant number NS047344) to HS. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments: We would like to acknowledge the helpful contributions of Sunu Kim (technical assistance) and Allan Gottschalk (critical commentary).Peer reviewedPublisher PD