Surface immobilization of hexa-histidine-tagged adeno-associated viral vectors for localized gene delivery.

Adeno-associated viral (AAV) vectors, which are undergoing broad exploration in clinical trials, have significant promise for therapeutic gene delivery because of their safety and delivery efficiency. Gene delivery technologies capable of mediating localized gene expression may further enhance the potential of AAV in a variety of therapeutic applications by reducing spread outside a target region, which may thereby reduce off-target side effects. We have genetically engineered an AAV variant capable of binding to surfaces with high affinity through a hexa-histidine metal-binding interaction. This immobilized AAV vector system mediates high-efficiency delivery to cells that contact the surface and thus may have promise for localized gene delivery, which may aid numerous applications of AAV delivery to gene therapy

Integer quantum Hall effect on a six valley hydrogen-passivated silicon (111) surface

We report magneto-transport studies of a two-dimensional electron system formed in an inversion layer at the interface between a hydrogen-passivated Si(111) surface and vacuum. Measurements in the integer quantum Hall regime demonstrate the expected sixfold valley degeneracy for these surfaces is broken, resulting in an unequal occupation of the six valleys and anisotropy in the resistance. We hypothesize the misorientation of Si surface breaks the valley states into three unequally spaced pairs, but the observation of odd filling factors, is difficult to reconcile with non-interacting electron theory.Comment: 4 pages, 4 figures, to appear in Physical Review Letter

Resonant Tunneling Between Quantum Hall Edge States

Resonant tunneling between fractional quantum Hall edge states is studied in the Luttinger liquid picture. For the Laughlin parent states, the resonance line shape is a universal function whose width scales to zero at zero temperature. Extensive quantum Monte Carlo simulations are presented for $\nu = 1/3$ which confirm this picture and provide a parameter-free prediction for the line shape.Comment: 14 pages , revtex , IUCM93-00

The effect of inter-edge Coulomb interactions on the transport between quantum Hall edge states

In a recent experiment, Milliken {\em et al.} demonstrated possible evidence for a Luttinger liquid through measurements of the tunneling conductance between edge states in the $\nu=1/3$ quantum Hall plateau. However, at low temperatures, a discrepancy exists between the theoretical predictions based on Luttinger liquid theory and experiment. We consider the possibility that this is due to long-range Coulomb interactions which become dominant at low temperatures. Using renormalization group methods, we calculate the cross-over behaviour from Luttinger liquid to the Coulomb interaction dominated regime. The cross-over behaviour thus obtained seems to resolve one of the discrepancies, yielding good agreement with experiment.Comment: 4 pages, RevTex, 2 postscript figures, tex file and figures have been uuencode

Correlation effects of carbon nanotubes at boundaries: Spin polarization induced by zero-energy boundary states

When a carbon nanotube is truncated with a certain type of edges, boundary states localized near the edges appear at the fermi level. Starting from lattice models, low energy effective theories are constructed which describe electron correlation effects on the boundary states. We then focus on a thin metallic carbon nanotube which supports one or two boundary states, and discuss physical consequences of the interaction between the boundary states and bulk collective excitations. By the renormalization group analyses together with the open boundary bosonization, we show that the repulsive bulk interactions suppress the charge fluctuations at boundaries, and assist the spin polarization.Comment: 8 pages, 1 figur

Dynamical electron transport through a nanoelectromechanical wire in a magnetic field

We investigate dynamical transport properties of interacting electrons moving in a vibrating nanoelectromechanical wire in a magnetic field. We have built an exactly solvable model in which electric current and mechanical oscillation are treated fully quantum mechanically on an equal footing. Quantum mechanically fluctuating Aharonov-Bohm phases obtained by the electrons cause nontrivial contribution to mechanical vibration and electrical conduction of the wire. We demonstrate our theory by calculating the admittance of the wire which are influenced by the multiple interplay between the mechanical and the electrical energy scales, magnetic field strength, and the electron-electron interaction

Interaction effects in multi-subband quantum wires

We investigate the effect of electron-electron interactions on the transport properties of disordered quasi one-dimensional quantum wires with two or more subbands occupied. We apply two alternative methods to solve the logarithmic divergent problem, namely the parquet graph theory and a renormalization group calculation. We solve the group equations analytically in the weak coupling limit and find a power-law for the temperature dependent conductivity of a multi-channel system. The exponent is roughly equal to the inverse of the number of the occupied subbands.Comment: 4 pages, style-files included. No figure. Appears in J. Phys. Soc. Japan (Letter

Scaling and non-Abelian signature in fractional quantum Hall quasiparticle tunneling amplitude

We study the scaling behavior in the tunneling amplitude when quasiparticles tunnel along a straight path between the two edges of a fractional quantum Hall annulus. Such scaling behavior originates from the propagation and tunneling of charged quasielectrons and quasiholes in an effective field analysis. In the limit when the annulus deforms continuously into a quasi-one-dimensional ring, we conjecture the exact functional form of the tunneling amplitude for several cases, which reproduces the numerical results in finite systems exactly. The results for Abelian quasiparticle tunneling is consistent with the scaling anaysis; this allows for the extraction of the conformal dimensions of the quasiparticles. We analyze the scaling behavior of both Abelian and non-Abelian quasiparticles in the Read-Rezayi Z_k-parafermion states. Interestingly, the non-Abelian quasiparticle tunneling amplitudes exhibit nontrivial k-dependent corrections to the scaling exponent.Comment: 16 pages, 4 figure

Randomness at the Edge: Theory of Quantum Hall transport at filling ν=2/3\nu=2/3

Current Luttinger liquid edge state theories for filling $\nu=2/3$ predict a non-universal Hall conductance, in disagreement with experiment. Upon inclusion of random edge tunnelling we find a phase transition into a new disordered-dominated edge phase. An exact solution of the random model in this phase gives a quantized Hall conductance of 2/3 and a neutral mode propagating upstream. The presence of the neutral mode changes the predicted temperature dependence for tunnelling through a point contact from $T^{2/\nu -2}$ to $T^2$.Comment: 12 pages 1 postscript figure appended, REVTEX 3.

Anomalous tunneling conductances of a spin singlet \nu=2/3 edge states: Interplay of Zeeman splitting and Long Range Coulomb Interaction

The point contact tunneling conductance between edges of the spin singlet $\nu=2/3,\hat{K}=(3/3/0)$ quantum Hall states is studied both in the quasiparticle tunneling picture and in the electron tunneling picture. Due to the interplay of Zeeman splitting and the long range Coulomb interaction between edges of opposite chirality novel spin excitations emerge, and their effect is characterized by anomalous exponents of the charge and spin tunneling conductances in various temperature ranges. Depending on the kinds of scatterings at the point contact and the tunneling mechanism the anomalous interaction in spin sector may enhance or suppress the tunneling conductances. The effects of novel spin excitation are also relevant to the recent NMR experiments on quantum Hall edges.Comment: Revtex File, 7 pages: To be published in Physical Reviews