A green bio-organic catalyst (taurine) promoted one-pot synthesis of (R/S)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches

Owing to the massive importance of dihydropyrimidine (DHPMs) scaffolds in the pharmaceutical industry and other areas, we developed an effective and sustainable one-pot reaction protocol for the synthesis of (R/S)-2-thioxo-DHPM-5-carboxanilides via the Biginelli-type cyclo-condensation reaction of aryl aldehydes, thiourea and various acetoacetanilide derivatives in ethanol at 100 °C. In this protocol, taurine was used as a green and reusable bio-organic catalyst. Twenty-three novel derivatives of (R/S)-TDHPM-5-carboxanilides and their structures were confirmed by various spectroscopy techniques. The aforementioned compounds were synthesized via the formation of one asymmetric centre, one new C–C bond, and two new C–N bonds in the final product. All the newly synthesized compounds were obtained in their racemic form with up to 99% yield. In addition, the separation of the racemic mixture of all the newly synthesized compounds was carried out by chiral HPLC (Prep LC), which provided up to 99.99% purity. The absolute configuration of all the enantiomerically pure isomers was determined using a circular dichroism study and validated by a computational approach. With up to 99% yield of 4d, this one-pot synthetic approach can also be useful for large-scale industrial production. One of the separated isomers (4R)-(+)-4S developed as a single crystal, and it was found that this crystal structure was orthorhombic

A green bio-organic catalyst (taurine) promoted one-pot synthesis of (R/S)-2-thioxo-3,4-dihydropyrimidine(TDHPM)-5-carboxanilides: chiral investigations using circular dichroism and validation by computational approaches

Owing to the massive importance of dihydropyrimidine (DHPMs) scaffolds in the pharmaceutical industry and other areas, we developed an effective and sustainable one-pot reaction protocol for the synthesis of (R/S)-2-thioxo-DHPM-5-carboxanilides via the Biginelli-type cyclo-condensation reaction of aryl aldehydes, thiourea and various acetoacetanilide derivatives in ethanol at 100 °C. In this protocol, taurine was used as a green and reusable bio-organic catalyst. Twenty-three novel derivatives of (R/S)-TDHPM-5-carboxanilides and their structures were confirmed by various spectroscopy techniques. The aforementioned compounds were synthesized via the formation of one asymmetric centre, one new C–C bond, and two new C–N bonds in the final product. All the newly synthesized compounds were obtained in their racemic form with up to 99% yield. In addition, the separation of the racemic mixture of all the newly synthesized compounds was carried out by chiral HPLC (Prep LC), which provided up to 99.99% purity. The absolute configuration of all the enantiomerically pure isomers was determined using a circular dichroism study and validated by a computational approach. With up to 99% yield of 4d, this one-pot synthetic approach can also be useful for large-scale industrial production. One of the separated isomers (4R)-(+)-4S developed as a single crystal, and it was found that this crystal structure was orthorhombic

Assessment of denture hygiene maintenance among elderly patients in Nizamabad (Telangana) population: A survey

Objective: To determine the denture cleanliness and denture hygiene habits in complete denture wearers in Nizamabad′s population. Materials and Methods: In this study, a self-administered structured questionnaire was developed to know the attitude of the patients from the Department of Prosthodontics regarding denture hygiene. The study sample consisted of a total of 200 subjects, which included 110 (55%) males and 90 (45%) females. Results: Nearly half of the subjects cleaned their dentures daily (70%). Participants from the younger age group and who had been wearing dentures from 0 years to 5 years maintained a better frequency of cleaning. The majority of these subjects used brush and toothpaste for denture cleansing. After seeing the condition, approximately half of the dentures were rated as dirty (48%). Around 41% of patients were not satisfied with their cleansing methods and 78.5% of the patients claimed that their dentists did not inform them about how to clean their dentures. Older dentures tended to be dirtier than the newer ones (P = 0.0001) and had a higher incidence rate of accompanying denture stomatitis (P = .0001). Conclusion: The poor condition of complete dentures seen in the population was mainly due to irregular cleansing habits and also less usage of cleansing solutions. Dentists should give proper instructions regarding the maintenance of denture hygiene

Nickel Catalyzed Selective Arylation of Geminal Dinitriles: Direct Access to α‑Cyano Carbonyl Compounds

The catalytic intermolecular arylation of disubstituted geminal dinitriles with in situ generated arylnickel complexes is disclosed. This method efficiently provides various all-carbon substituted α-cyanocarbonyl compounds without additives and an inert atmosphere. It also demonstrates the arylation of R-BINOL and S-BINOL derived geminal dinitriles, preserving optical purity. Mechanistic studies proved that the in situ generated organonickel complex is involved in arylation

Nickel Catalyzed Selective Arylation of Geminal Dinitriles: Direct Access to α‑Cyano Carbonyl Compounds

The catalytic intermolecular arylation of disubstituted geminal dinitriles with in situ generated arylnickel complexes is disclosed. This method efficiently provides various all-carbon substituted α-cyanocarbonyl compounds without additives and an inert atmosphere. It also demonstrates the arylation of R-BINOL and S-BINOL derived geminal dinitriles, preserving optical purity. Mechanistic studies proved that the in situ generated organonickel complex is involved in arylation