Formulation and evaluation of microemulsion containing miconazole nitrate

The aim of the present research is to formulate a microemulsion containing miconazole nitrate as it provides various advantages over conventional dosage form. It also put forward the idea for the formulation of microemulsion containing miconazole nitrate with the use of varying surfactant and co- surfactants   with an objective to increase the better drug loading, high transparency, high thermodynamic stability, better bioavailability and ease of preparation. Miconazole nitrate is hydrophobic imidazole antifungal agent. The studies show that it is highly effective in the topical treatment of fungal infections. Due to the presence of both lipophilic and hydrophilic domains, a wide range of lipophilic and hydrophilic domains are incorporated in these systems

Formulation and evaluation of microemulsion containing griseofulvin

The aim of the following research is to formulate a microemulsion containing drug Griseofulvin. Griseofulvin is an antifungal agent which inhibits the mitosis. It is recommended orally for treatment of fungal disease.  It is used to treat skin infections such as jock itch, athletes foot and ringworm. Also it is used to treat the fungal infections of scalp, toenails and fingernails. Griseofulvin is a BCS II class drug. It is highly lipophilic poorly soluble drug with low oral bioavailability. The present aim was to increase the solubility by microemulsion system for topical delivery. Microemulsions are clear, stable and isotropic liquid. They show advantages such as spontaneous preparation, scale up, ease of preparation, improving drug solubility of hydrophobic drugs. It is also used to increase the bioavailability of drug. These also aim at controlling the bioavailability of various drug molecules. The review put forward the development in microemulsion containing system. They improve solubility, chemical stability and oral bioavailability of poorly water soluble drugs. There is formulation of four different batches. The batches differ in quantity of surfactant and co- surfactants

Formulation and evaluation of econazole nitrate microemulsion

Econazole Nitrate microemulsion is presently considered as the novel drug delivery system. It shows prolonged action. It is considered as the imidazole antifungal agent which shows broad spectrum activity. Antifungal agent contains the lipophilic groups which are administered in the microemulsions as they are able to penetrate the system easily. It belongs to BCS Class II drug. i.e., low soluble and highly permeable. The drug efficacy of topical formulation is limited to instability due to poor solubility and low permeability. These are the basic reasons which increase the scope for designing of microemulsion. The topical microemulsion containing Econazole Nitrate prepared using oleic acid as the oil phase, tween 20 as surfactant and propylene glycol as co- surfactant. The optimized formulation B1 was evaluated for various tests such as Particle size, Zeta potential, pH, Viscosity, Scanning electron microscopy and Electrical conductivity

Formulation and Evaluation of Microemulsion Containing Miconazole Nitrate

The aim of the present research is to formulate a microemulsion containing miconazole nitrate as it provides various advantages over conventional dosage form. It also put forward the idea for the formulation of microemulsion containing miconazole nitrate with the use of varying surfactant and co- surfactants   with an objective to increase the better drug loading, high transparency, high thermodynamic stability, better bioavailability and ease of preparation. Miconazole nitrate is hydrophobic imidazole antifungal agent. The studies show that it is highly effective in the topical treatment of fungal infections. Due to the presence of both lipophilic and hydrophilic domains, a wide range of lipophilic and hydrophilic domains are incorporated in these systems