Synthesis and Application of MOF-808 Decorated with Folic Acid-Conjugated Chitosan as a Strong Nanocarrier for the Targeted Drug Delivery of Quercetin

Herein, MOF-808 (MOF = metal–organic framework) based on zirconium tricarboxylate was synthesized to investigate the influence of decorating groups of folic acid-conjugated chitosan (CS-FA) on drug-delivery efficiency. Quercetin (QU) was loaded on nondecorated MOF-808 and then decorated with a folic acid–chitosan conjugate. The properties and activities of modified MOF-808 were compared with unmodified MOF-808. QU@MOF-808@CS-FA exhibited favorable drug-release properties, high drug-loading capacity, efficient targeting capability, and pH-dependent release behavior, highlighting the critical role of organic modification. A variety of characterization techniques were used to characterize MOF nanoparticles, including Fourier transform infrared, powder X-ray diffraction, field-emission scanning electron microscopy, energy-dispersive X-ray, transmission electron microscopy, Brunauer–Emmett–Teller, ζ potential, and 1H NMR. Additionally, Monte Carlo simulation calculations were carried out to examine the interactions between the structures of MOF-808 and QU. An in vitro cytotoxicity test was conducted, and the results identified that QU@MOF-808@CS-FA demonstrated more superior therapeutics than QU@MOF-808 on FR-positive MCF7 cancerous cells. On the basis of the results, QU@MOF-808@CS-FA is a promising drug carrier by selective targeting and sustained release

Solid-State Structural Transformations of Two Ag^I Supramolecular Polymorphs to Another Polymer upon Absorption of HNO₃ Vapors

Solid-state structural transformation of two polymorphic forms of [Ag­(8-HqH)­(8-Hq)]_<i>n</i> (<b>1α</b> and <b>1β</b>, where 8-HqH = 8-hydroxyquinoline and 8-Hq^– = 8-hydroxyquinolate) to {[Ag­(8-HqH)₂]­NO₃}_<i>n</i> (<b>2</b>) has been observed upon solid–gas reaction of compounds <b>1α</b> and <b>1β</b> with HNO₃ vapors. Solid–gas reaction of compound <b>2</b> with hydrated vapors of NH₃ results in the formation of only the <b>1β</b> polymorph, while solid–solid reaction of compound <b>2</b> with KOH results in the formation of a <b>1α</b> and <b>1β</b> mixture with chiral and achiral space groups of <i>P</i>2₁2₁2₁ and <i>Pbcn</i>, respectively

Computational Simulation of CO₂/CH₄ Separation on a Three-Dimensional Cd-Based Metal–Organic Framework

Natural gas purification and biogas recovery require efficient separation of CO2 from CH4, as CH4 is increasingly being recognized as a promising substitute for petroleum due to its environmentally sustainable nature, abundance in natural resources, and economic benefits. In the present work, a 3D Cd-based metal–organic framework, [Cd2(DBrTPA)2(DMF)3] (MUT-11) 2,5-[dibromoterephthalic acid (DBrTPA) and dimethyl formamide (DMF)] was synthesized using a combination of different synthetic methods and fully characterized via several techniques. Additionally, a variety of organic solvents were employed to perform the solvent stability test. The MUT-11 structure was subjected to Grand Canonical Monte Carlo and molecular dynamics simulations to study the adsorption characteristics of CO2 and CH4 gases in both pure and binary states. The results acquired through the simulation-based analysis revealed that the adsorption of CO2 is dominant in all pressure and temperature conditions