70 research outputs found

    Loops under Strategies ... Continued

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    While there are many approaches for automatically proving termination of term rewrite systems, up to now there exist only few techniques to disprove their termination automatically. Almost all of these techniques try to find loops, where the existence of a loop implies non-termination of the rewrite system. However, most programming languages use specific evaluation strategies, whereas loop detection techniques usually do not take strategies into account. So even if a rewrite system has a loop, it may still be terminating under certain strategies. Therefore, our goal is to develop decision procedures which can determine whether a given loop is also a loop under the respective evaluation strategy. In earlier work, such procedures were presented for the strategies of innermost, outermost, and context-sensitive evaluation. In the current paper, we build upon this work and develop such decision procedures for important strategies like leftmost-innermost, leftmost-outermost, (max-)parallel-innermost, (max-)parallel-outermost, and forbidden patterns (which generalize innermost, outermost, and context-sensitive strategies). In this way, we obtain the first approach to disprove termination under these strategies automatically.Comment: In Proceedings IWS 2010, arXiv:1012.533

    Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases

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    The production of peroxide and superoxide is an inevitable consequence of aerobic metabolism, and while these particular "reactive oxygen species" (ROSs) can exhibit a number of biological effects, they are not of themselves excessively reactive and thus they are not especially damaging at physiological concentrations. However, their reactions with poorly liganded iron species can lead to the catalytic production of the very reactive and dangerous hydroxyl radical, which is exceptionally damaging, and a major cause of chronic inflammation. We review the considerable and wide-ranging evidence for the involvement of this combination of (su)peroxide and poorly liganded iron in a large number of physiological and indeed pathological processes and inflammatory disorders, especially those involving the progressive degradation of cellular and organismal performance. These diseases share a great many similarities and thus might be considered to have a common cause (i.e. iron-catalysed free radical and especially hydroxyl radical generation). The studies reviewed include those focused on a series of cardiovascular, metabolic and neurological diseases, where iron can be found at the sites of plaques and lesions, as well as studies showing the significance of iron to aging and longevity. The effective chelation of iron by natural or synthetic ligands is thus of major physiological (and potentially therapeutic) importance. As systems properties, we need to recognise that physiological observables have multiple molecular causes, and studying them in isolation leads to inconsistent patterns of apparent causality when it is the simultaneous combination of multiple factors that is responsible. This explains, for instance, the decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference

    Myocyte membrane and microdomain modifications in diabetes: determinants of ischemic tolerance and cardioprotection

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    STRUCTURE OF VENUS ATMOSPHERE FROM MODELING OF NIGHT-SIDE INFRARED-SPECTRA

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    The surface and lower atmosphere of Venus lie below long path-lengths of carbon dioxide and water vapour, and thick cloud layers that were, until recently, thought to be essentially opaque to electromagnetic radiation at wavelengths shorter than a few millimetres. It was unexpected, therefore, when Alien and Crawford 1 announced the detection of measurable quantities of near-infrared radiation leaving the night side. Here we investigate the origin of this radiation by calculating theoretical spectra which we compare with the observations. It is found that the observed radiation can be fully accounted for by thermal emission from the deep atmosphere, and that the intensities suggest surprisingly low abundances for water vapour and carbon monoxide in those layers. These results have implications for probing the atmospheric structure and composition on Venus from the Galileo spacecraft, which is scheduled to make a close encounter with Venus in February 1990. © 1988 Nature Publishing Group

    Millimeter and submillimeter measurements of asteroid (2867) Steins during the Rosetta fly-by

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    International audienceThe European Space Agency Rosetta Spacecraft passed within 803 km of the main belt asteroid (2867) Steins on 5 September 2008. The Rosetta Spacecraft carries a number of scientific instruments including a millimeter and submillimeter radiometer and spectrometer. The instrument, named MIRO (Microwave Instrument for the Rosetta Orbiter), consists of a 30-cm diameter, offset parabolic reflector telescope followed by two heterodyne receivers. Center-band operating frequencies of the receivers are near 190 GHz (1.6 mm) and 562 GHz (0.53 mm). Broadband continuum channels are implemented in both frequency bands for the measurement of near surface temperatures and temperature gradients. A 4096 channel CTS (chirp transform spectrometer) having 180 MHz total bandwidth and ˜44 kHz resolution is also connected to the submillimeter receiver. We present the continuum observations of asteroid (2867) Steins obtained during the fly-by with the MIRO instrument. Spectroscopic data were also collected during the fly-by using the MIRO spectrometer fixed-tuned to rotational lines of several molecules. Results of the spectroscopic investigation will be the topic of a separate publication. Comparative thermal models and radiative transfer calculations for Steins are presented. Emissivities of Steins were determined to be 0.6-0.7 and 0.85-0.9 at wavelengths of 0.53 and 1.6 mm, respectively. The thermal inertia of Steins was estimated to be in the range 450-850 J/(m 2 s 0.5 K). Assuming that the emissivity of Steins is determined by the Fresnel reflection coefficients of the surface material, the area-averaged dielectric constant of the surface material is in the range 4-20. These values are rock-like, and are unlike the powdered-regolith surface of the Moon
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