Uticaj ekološkog zagađenja izazvanog delovanjem NATO alijanse na prostorima Srbije na fiziološki status proizvoda tipa 'Radler'

Beer-based drinks, 'Radler' type products in particular, arouse interest for a number of reasons. These newly produced drinks were obtained by mixing beer and soft drinks and are intended for a larger number of target groups than their each single component. Also, they combine advantages of both components in physiological respect. They have lower alcohol content than beer, are more palatable and refreshing, can be consumed in larger amounts, retaining beneficial and physiological value of beer. As NATO air strikes resulted in heavy environmental contamination, the question is raised about the safety of these drinks and the level of toxic elements in them as well about the level of micro- and macro-elements having beneficial effects on the body. The paper gives the analysis results for 35 samples of different 'Radler' Beer-based products manufactured by domestic producers. The level of elements belonging to three distinct groups of heavy metals and that of the most important micro- and macro-elements, of therapeutic and physiological value for the body, were determined. The obtained values were compares with available data on similar products in the world, with values obtained for domestic products in the period preceding environmental contamination, and, in the case of biologically important elements, with their contents in one of oligomineral-vitamin products.Pića na bazi piva, a pogotovo proizvodi tipa 'Radler' interesantni su sa vise aspekata. Predstavljaju jedan nov proizvod dobijen kombinacijom piva i gaziranih bezalkoholnih pica namenjen većem broju ciljnih grupa od pojedinačnih komponenata od kojih su proizvedeni, a ujedno sa fiziološkog aspekta objedinjuju prednosti svakog od njih. Sadrže niži sadržaj alkohola od piva, pitkija su i vise osvežavaju, mogu se piti u većim količinama, a istovremeno u određenoj meri zadržavaju blagotvorna i fiziološki vrlo povoljna svojstva piva. Upravo iz tog razloga postavlja se pitanje njihove zdravstvene ispravnosti i prisustva pojedinih toksičnih elemenata kao posledica ekološkog zagađenja uzrokovanog vazdušnim dejstvima NATO alijanse, odnosno mikro- i makro elemenata čiji sadržaj ima povoljno delovanje na organizam. U radu su prikazani rezultati analize 35 uzoraka različitih 'Radler' proizvoda dobijenih na bazi piva različitih domaćih proizvođača. Određen je sadržaj elemenata koji spadaju u tri karakteristične grupe teških metala kao i najznačajnijih mikro- i makroelemenata koji imaju terapeutski i fiziološki značaj za organizam. Rezultati analize 35 uzoraka proizvoda tipa 'Radler' proizvedenih nakon završetka ratnih dejstava, pokazuju da u pogledu ni jednog toksičnog elementa nije došlo do porasta sadržaja i da su nađene vrednosti u granicama, ili čak ispod vrednosti karakterističnih za proizvode ove vrste na domaćem tržištu. Vrednosti su znatno ispod zakonski regulisanih maksimuma i u granicama koje se sreću i u srodnim proizvodima u svetu. Sa druge strane, interesantni su podaci koji se odnose na prisustvo biogenih elemenata koji su uzrok povoljnog delovanja piva na organizam. Njihov sadržaj u proizvodima tipa 'Radler' je niži u odnosu na pivo i ovi proizvodi se ne mogu tretirati kao njihov izvor. Međutim, poređenje sa oligomineralnim vitaminskim preparatom 'Oligovitom' (ICN) ukazuje na neke interesantne činjenice. Unošenjem 1 l ovih proizvoda unosi se 10% Mg, 10-60% Mn, 30% Cu, 50% Zn i 50% Co koja se inače unosi pilulom 'Oligovita' kao preporučena dnevna dopuna svakodnevne ishrane dece i odraslih

Novel insights to the anti-proliferative activity of rosemary (Rosmarinus officinalis L.) co-treatment

The aim of this study was to characterize volatile and non-volatile compounds of rosemary from the North Adriatic region and to determine its antiproliferative activity, alone or in combination with radiomimetic bleomycin (BLM) on three malignant and one non-transformed human cell line. Chemical analysis of the volatile compounds revealed the presence of monoterpenes (93.8%), in which 1.8-cineol (32.9%) and camphor (15.5%) were the dominant compounds. Also, obtained results showed that the major polyphenolic constituents in rosemary extract were phenolic acids (rosmarinic acid and its derivatives up to 69.2 mg 100 g-1), as well as flavones and flavonols in the following order: luteolin>isorhamnetin>quercetin>kaempferol>apigenin. Cell growth test showed that rosemary extract alone exerted moderate antiproliferative activity, as well as a synergistic antiproliferative effect with bleomycin (EC50 344.3-461.5 µg mL-1 and 58.6-292 µg mL-1, respectively). The anti-tumor effect of rosemary extract in combination with BLM was much stronger, compared to BLM itself on the breast cancer cells. Through their proposed sensitizing effect, rosemary extracts, in combination with the standard chemotherapeutics, could be used for the investigations of possible therapeutic modalities

SUMMARY

Contemporary cancer chemotherapy need to be active against malignant cell (selectivity), to be based on the molecular biology of the cancer cell, to enhance immune response to cancer, and to stop development of resistance to drug. Research in this field is expensive, as well as the cost of newly discovered drugs. Targeted therapies are registered in the Republic of Serbia and their applications are controlled by the state authority. At the Oncology Institute of Vojvodina smaller number of patients was treated with targeted therapy than with classical chemotherapy. However, our costs for treating patients with monoclonal therapies are at the level of those worldwide. Key words: Economics, Pharmaceutical; Medical Oncology; Drug Delivery Systems The current chemotherapy is not selective in destroying malignant cells. It has no influence to basic molecular changes in cancer cells, has no power to eliminate all malignant cells, and thus makes possible for malignant cells to develop resistance to anticancer drugs (1)

Uticaj ekološkog zagađenja izazvanog delovanjem NATO alijanse na prostorima Srbije na fiziološki status proizvoda tipa "Radler"

Beer-based drinks, 'Radler' type products in particular, arouse interest for a number of reasons. These newly produced drinks were obtained by mixing beer and soft drinks and are intended for a larger number of target groups than their each single component. Also, they combine advantages of both components in physiological respect. They have lower alcohol content than beer, are more palatable and refreshing, can be consumed in larger amounts, retaining beneficial and physiological value of beer. As NATO air strikes resulted in heavy environmental contamination, the question is raised about the safety of these drinks and the level of toxic elements in them as well about the level of micro- and macro-elements having beneficial effects on the body. The paper gives the analysis results for 35 samples of different 'Radler' Beer-based products manufactured by domestic producers. The level of elements belonging to three distinct groups of heavy metals and that of the most important micro- and macro-elements, of therapeutic and physiological value for the body, were determined. The obtained values were compares with available data on similar products in the world, with values obtained for domestic products in the period preceding environmental contamination, and, in the case of biologically important elements, with their contents in one of oligomineral-vitamin products.Pića na bazi piva, a pogotovo proizvodi tipa „Radler" interesantni su sa više aspekata. Predstavljaju jedan nov proizvod dobijen kombinacijom piva i gaziranih bezalkoholnih pića namenjen većem broju ciljnih grupa od pojedinačnih komponenata od kojih su proizvedeni, a ujedno sa fiziološkog aspekta objedinjuju prednosti svakog od njih. Sadrže niži sadržaj alkohola od piva, pitkija su i više osvežavaju, mogu se piti u većim količinama, a istovremeno u određenoj meri zadržavaju blagotvorna i fiziološki vrlo povoljna svojstva piva. Upravo iz tog razloga postavlja se pitanje njihove zdravstvene ispravnosti i prisustva pojedinih toksičnih elemenata kao posledica ekološkog zagađenja uzrokovanog vazdušnim dejstvima NATO alijanse, odnosno mikro- i makro elemenata čiji sadržaj ima povoljno delovanje na organizam. U radu su prikazani rezultati analize 35 uzoraka različitih Radler proizvoda dobijenih na bazi piva različitih domaćih proizvođača. Određen je sadržaj elemenata koji spadaju u tri karakteristične grupe teških metala kao i najznačajnijih mikro- i makroelemenata koji imaju terapeutski i fiziološki značaj za organizam. Rezultati analize 35 uzoraka proizvoda tipa „Radler" proizvedenih nakon završetka ratnih dejstava, pokazuju da u pogledu ni jednog toksičnog elementa nije došlo do porasta sadržaja i da su nađene vrednosti u granicama, ili čak ispod vrednosti karakterističnih za proizvode ove vrste na domaćem tržištu. Vrednosti su znatno ispod zakonski regulisanih maksimuma i u granicama koje se sreću i u srodnim proizvodima u svetu. Sa druge strane, interesantni su podaci koji se odnose na prisustvo biogenih elemenata koji su uzrok povoljnog delovanja piva na organizam. Njihov sadržaj u proizvodima tipa „Radler" je niži u odnosu na pivo i ovi proizvodi se ne mogu tretirati kao njihov izvor. Međutim, poređenje sa oligomineralnim vitaminskim preparatom „Oligovitom" (ICN) ukazuje na neke interesantne činjenice. Unošenjem 1 l ovih proizvoda unosi se 10% Mg, 10-60% Mn, 30% Cu, 50% Zn i 50% Co koja se inače unosi pilulom „Oligovita" kao preporučena dnevna dopuna svakodnevne ishrane dece i odraslih