A characterization of weighted approximations by the Post–Widder and the Gamma operators, II

AbstractWe present a characterization of the approximation errors of the Post–Widder and the Gamma operators in Lp(0,∞),1≤p≤∞, with a weight xγ0(1+x)γ∞−γ0 with arbitrary real γ0,γ∞. Characteristics of two types are used — weighted K-functionals of the approximated function itself and the classical fixed-step moduli of smoothness taken on simple modifications of it

High signal-to-noise spectral characterization of the planetary-mass object HD 106906 b

We spectroscopically characterize the atmosphere of HD 106906b, a young low-mass companion near the deuterium burning limit. The wide separation from its host star of 7.1" makes it an ideal candidate for high S/N and high-resolution spectroscopy. We aim to derive new constraints on the spectral type, effective temperature, and luminosity of HD106906b and also to provide a high S/N template spectrum for future characterization of extrasolar planets. We obtained 1.1-2.5 $\mu$m integral field spectroscopy with the VLT/SINFONI instrument with a spectral resolution of R~2000-4000. New estimates of the parameters of HD 106906b are derived by analyzing spectral features, comparing the extracted spectra to spectral catalogs of other low-mass objects, and fitting with theoretical isochrones. We identify several spectral absorption lines that are consistent with a low mass for HD 106906b. We derive a new spectral type of L1.5$\pm$1.0, one subclass earlier than previous estimates. Through comparison with other young low-mass objects, this translates to a luminosity of log($L/L_\odot$)=$-3.65\pm0.08$ and an effective temperature of Teff=$1820\pm240$ K. Our new mass estimates range between $M=11.9^{+1.7}_{-0.8} M_{\rm Jup}$ (hot start) and $M=14.0^{+0.2}_{-0.5} M_{\rm Jup}$ (cold start). These limits take into account a possibly finite formation time, i.e., HD 106906b is allowed to be 0--3 Myr younger than its host star. We exclude accretion onto HD 106906b at rates $\dot{M}>4.8\times10^{-10} M_{\rm Jup}$yr$^{-1}$ based on the fact that we observe no hydrogen (Paschen-$\beta$, Brackett-$\gamma$) emission. This is indicative of little or no circumplanetary gas. With our new observations, HD 106906b is the planetary-mass object with one of the highest S/N spectra yet. We make the spectrum available for future comparison with data from existing and next-generation (e.g., ELT and JWST) spectrographs.Comment: 11 pages, 5 figures. Accepted for publication in Astronomy & Astrophysics. Fully reduced spectra will be made available for download on CD

Molecular Beams

Contains reports on four research projects.Lincoln Laboratory, Purchase Order DDL B-00283U. S. ArmyU. S. NavyU. S. Air Force under Air Force Contract AF 19(604)-520

Pedunculopontine tegmental nucleus. Part I: cytoarchitecture, transmitters, development and connections

The present review compiles data on the cytoarchitecture, transmitters, development, afferent and efferent connections of the pedunculopontine tegmental nucleus (PPN). PPN is a reticular formation nucleus, located in the pontomesencephalic tegmentum, closely associated with the ascending limb of the superior cerebellar peduncle. Its most typical cells are cholinergic and comprise the Ch5 neuronal group of Mesulam. It contains also glutamatergic neurons that may contain glutamate as a sole transmitter or as a co-transmitter of acetylcholine. The cholinergic neurons use also the gaseous transmitter nitric oxide, being the most prominent nitrergic neurons in the central nervous system (CNS). In aged animals, there is practically no cell loss but there are certain drastic changes in the somatodendritic morphology. PPN has an extremely rich afferent input. All basal ganglia send axons to PPN, the strongest connection being from the substantia nigra (SN), followed by pathways arising from the subthalamic nucleus (STN) and from both pallidal segments (PAL). PPN receives afferents also from the cerebral cortex, from areas of the limbic system and hypothalamus, from the cerebellum, from the brainstem - particularly serotoninergic axons from the raphe nuclei and noradrenergic axons from the locus ceruleus - as well as from the spinal cord. The efferent connections of PPN are extremely diverse, and some of them are carried out by axons that emit divergent collaterals to two different structures. The heaviest efferent pathway of PPN is destined to the thalamus, innervating virtually all thalamic nuclei, and especially the "nonspecific" intralaminar nuclei, that innervate broad ares of the cerebral cortex. All basal ganglia are innervated and in most cases the connection is bilateral. The most significant pathway innervates the dopaminergic neurons of SN, followed by a connection to STN and PAL. Other PPN efferent connections reach the cerebellum, the superior colliculus, nuclei of cranial nerves, the reticular formation, and the spinal cord. The reviewed connections of PPN suggest that it is involved significantly in the arousal systems, and is implicated in the disturbances of sleep and wakefulness. PPN is also involved in the motor functions of CNS, as well as in the movement disorders.Biomedical Reviews 2003; 14: 95-120

Leydig cell-immune cell interaction: an example of neuroendocrine-immune communication in testis

In her paper "Tilings will never be the same again" Dr Kathleen L. Wishner quoted Alvin Toffler's book Future Shock written in 1970. Toffler defined "future shock" as a time phenomenon, a product of the greatly accelerated change in society. The scientific research itself is a demonstration of this accelerated change. In particular, data systematized by Davidoff et al in this volume of Biomedical Reviews indicate the change in the understanding of the nature and origin of Leydig cells of the human testis.Biomedical Reviews 1996; 6: 1-4

Cigarette smoking disparities among sexual minority cancer survivors

AbstractObjectiveSexual minority (i.e., lesbian, gay, and bisexual) adults smoke cigarettes at higher rates than heterosexual adults. Smoking after receiving a cancer diagnosis is a major health concern, yet risk of continued smoking among sexual minority cancer survivors is as yet unknown. The current study examines current smoking among sexual minority vs. heterosexual adult cancer survivors.MethodData drawn from the 2010 Behavioral Risk Factor Surveillance System survey in five states (Alaska, California, Massachusetts, New Mexico, and Wisconsin) included items about sexual orientation, cancer diagnosis, and tobacco use. The analytic sample included 124 sexual minority and 248 propensity score matched heterosexual adult cancer survivors.ResultsBivariate analysis showed that sexual minority cancer survivors had twice the odds of current smoking as their heterosexual counterparts (OR=2.03, 95%CI:1.09–3.80). In exploratory analyses stratified by sex, sexual minority disparities in prevalence of smoking post-cancer showed a trend toward significance among females, not males.ConclusionThe current study offers preliminary evidence that sexual minority status is one variable among many that must be taken into account when assessing health behaviors post-cancer diagnosis. Future research should identify mechanisms leading from sexual minority status to increased rates of smoking and develop tailored smoking cessation interventions

A suggestive neurotrophic potential of mast cells in heart and submandibular glands of the rat

According to the neurotrophic theory, the nerve growth factor (NGF) is widely distributed in the effector tissues of peripheral sympathetic and sensory neurons, suggesting that the density of innervation is controlled by effector derived NGF. Sympathetic neurons require access to NGF for survival throughout life, whereas sensory neurons are dependent on NGF only during restricted period of embryonic development. This development-related feature of sympathetic neurons suggests that they crucially depend on plasticity of NGF biology, including secretion, availability, and utilization, to maintain appropriate neuronal function in adult life, and even in old age. While most previous studies on the cellular source of NGF have focused on neuronal and nonneuronal effector cells, it was recently demonstrated that NGF secretion is not only restricted to cells receiving a direct innervation. Immune cells, including mast cells (MC), lymphocytes and macrophages, for example, produce and release NGF as well as NGF secretion-inducing cytokines. Likewise, since the first evidence that NGF treatment causes a significant increase in the number and size of MC has been published by Aloe and Levi-Montalcini in 1977, it has been repeatedly shown that these cells are also NGF-responsive cells, thus providing further evidence for a widely investigated MC-nerve interaction. Further on this trophobiological line, a positive correlation of the amount of NGF and expression of NGF mRNA with the density of sympathetic innervation was demonstrated in a variety of organs. In the rat heart, one such example, the atrium contains a higher amount of NGF corresponding to a denser sympathetic nerve supply compared to the ventricle. Such a correlation was also revealed in the submandibular glands (SMG) and iris. Likewise, the density of MC in the ankle joint capsule, which is heavily innervated, is greater than in the capsule of the knee, which is less densely innervated, and the MC number in the synovial joint of spontaneously hypertensive rats, which have increased sympathetic nerve supply, is significantly greater than in normotensive rats. A summing-up of the above mentioned data shows that (i) MC are NGF secreting/responsive cells and frequently colocalized with nerves, and (ii) a higher NGF amount correlates with a denser sympathetic innervation of a tissue . This, in our eyes, brings into question the sole contribution of the "classical" effector cells to neurotrophic support of sympathetic nerve-innervated tissues. Consequently, we suggest that MC, through their own and/or cytokine-induced NGF secretion, may also be implicated in the neurotrophic potential in these tissues.Biomedical Reviews 1998; 9: 143-145

Noradrenergic-dependent functions are associated with age-related locus coeruleus signal intensity differences.

The locus coeruleus (LC), the origin of noradrenergic modulation of cognitive and behavioral function, may play an important role healthy ageing and in neurodegenerative conditions. We investigated the functional significance of age-related differences in mean normalized LC signal intensity values (LC-CR) in magnetization-transfer (MT) images from the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) cohort - an open-access, population-based dataset. Using structural equation modelling, we tested the pre-registered hypothesis that putatively noradrenergic (NA)-dependent functions would be more strongly associated with LC-CR in older versus younger adults. A unidimensional model (within which LC-CR related to a single factor representing all cognitive and behavioral measures) was a better fit with the data than the a priori two-factor model (within which LC-CR related to separate NA-dependent and NA-independent factors). Our findings support the concept that age-related reduction of LC structural integrity is associated with impaired cognitive and behavioral function