68 research outputs found
Segmentresektionen, eine adäquate Therapie bei funktionell limitierten Patienten mit NSCLC unabhängig von der Tumorgröße
Lazarus-Type Tumour Response to Therapy with Nivolumab for Sarcomatoid Carcinomas of the Lung
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small-cell lung carcinoma with a poor prognosis and poor response to chemotherapy and radiotherapy. A previous study reported that psc expresses high levels of PD-L1, suggesting the potential efficacy of immune checkpoint inhibitors in these tumours. We report 2 cases of patients with a lung sarcomatoid carcinoma. Both patients initially underwent curative lung resection, but developed early recurrent disease. Because PD-L1 was highly expressed in the tumour cells, we initiated therapy with nivolumab, which showed good efficacy, almost complete radiologic tumour remission, and a remarkable improvement in the condition of those patients. Immune checkpoint inhibitors targeting PD-1 might be a valuable therapy option for PSCS
Lazarus-type tumour response to therapy with nivolumab for sarcomatoid carcinomas of the lung
Docetaxel/nindetanib as efficient treatment option after failure of immune checkpoint inhibition: Real-world evidence
- …