A Case of Necrotizing Sialometaplasia of the Hard Palate Treated with Tranexamic Acid and Sodium Azulene Sulfonate

Necrotizing sialometaplasia is a benign lesion affecting the minor salivary glands of the hard palate. This lesion may be clinically and histopathologically confused with malignant lesions. A case of a 47-year-old man who presented with necrotizing sialometaplasia on the left side of the hard palate is herein reported. A biopsy was performed, and the condition was diagnosed based on immunohistochemistry. The lesion receded following treatment with tranexamic acid and sodium azulene sulfonate. The symptom of painful swelling on the hard palate subsided within 10 days. The palatal lesion had disappeared completely 4 months later

Solitary fibrous tumor of the buccal mucosa: A case report

Solitary fibrous tumors （SFTs） were reported in 1931 as tumors derived from mesenchymal tissue. They occur mainly in the pleura and peritoneum and rarely in the oral and maxillary regions. This report presents the case of a 48-year-old woman with a tumor in the left buccal mucosa. We suspected a salivary gland tumor or hemangioma. Excision was performed under general anesthesia. The lesion was removed as a single mass. Histopathological and immunohistochemical analyses led to the diagnosis of SFT. We report this case based on a literature review

Tumor protein D54: A promising marker of mucoepidermoid carcinoma

A definitive diagnosis of salivary gland tumors is extremely difficult to make without evaluating the entire tumor and conducting immunohistochemical examinations. In this study, we aimed to examine and compare the expression patterns of the tumor protein （TP） D52 family, including TPD52, TPD53, and TPD54, in salivary gland tumor cells by using immunohistochemical staining. Among over 30 benign and malignant salivary gland tumors with extensive and diverse morphological features and overlapping histological similarities, we selected Warthin’s tumor and pleomorphic adenoma to represent benign salivary gland tumors and mucoepidermoid carcinoma to represent malignant ones. Tumor samples were fixed in 10％ buffered formalin and embedded in paraffin. Then, immunohistochemical staining was performed using antibodies against TPD52, TPD53, and TPD54. Neither the benign salivary gland tumors nor mucoepidermoid carcinoma stained for TPD52. However, the intensity of TPD53 and TPD54 staining was found to be low in the benign salivary gland tumors and high in mucoepidermoid carcinoma. TPD54 may serve as a pathological indicator of benign salivary gland tumors and mucoepidermoid carcinoma

A Case of Spontaneous Passage of Salivary Calculus from the Parotid Gland Duct into the Oral Cavity

Sialolithiasis most commonly affects the submandibular glands, followed by the parotid and sublingual glands. Sialolithiasis is a condition characterized by the obstruction of a salivary gland or its excretory duct due to calculi. Herein we describe a case of a 72-year-old male patient with a painful swelling of the parotid gland region. Parotitis due to sialolithiasis in the parotid gland duct was diagnosed based on computed tomography findings of a calculus (12×6×5mm) in the parotid gland duct. The calculus was spontaneously discharged from the parotid gland duct with viscous pus into the oral cavity after the inflammation had decreased. Thereafter, the parotitis quickly decreased more markedly. This case indicates that a calculus may be discharged spontaneously into the mouth, even if its diameter is>5mm

Carcinoma of the dorsum of the tongue with lung carcinoma and duodenal carcinoma in one patient

Introduction: Squamous cell carcinoma (SCC) of the tongue is a common cancer of the oral region, generally occurring on the lateral surface of the tongue.Case report: We present a case of SCC of the dorsum of the tongue along with the development of two other primary cancers with different histologies in a 61-year-old Japanese woman, who presented with a mass on the dorsum of her tongue in 2017. Intraoral examination revealed a 2.5 × 1.5-cm tumor on the dorsum of the tongue without induration and covered with normal epithelium. She was previously diagnosed with carcinoma in an adenoma of the duodenum in 2013 and adenocarcinoma of the right lung in 2016. Computed tomography and magnetic resonance imaging revealed no evidence of malignant tumors in the head and neck region. The lesion of the tongue was surgically excised with a safe margin. Histological examination revealed well-differentiated SCCs that were completely excised.Discussion: This is a rare case of three primary cancers with different histologies in one patient. Clinicians should consider SCC of the dorsum of the tongue during diagnosis, since it is a rare region and the tumor may mimic benign tumors. Keywords: Adenocarcinoma of the lung, Squamous cell carcinoma of the tongue, Carcinoma in adenoma of the duodenum, Dorsum of the tongue, Triple carcinom

The Effects of Desflurane Versus Conventional Maintenance Anesthetics on the Incidence of Post-Operative Nausea and Vomiting in Patients Undergoing Laparoscopic Surgery―A Network Meta-Analysis of 4 Randomized Controlled Trials―

It is not fully known if there are significant differences in the incidence of post-operative nausea and vomiting（PONV）in patients undergoing laparoscopic surgery under general anesthesia following administration of desflurane compared to other conventional maintenance anesthetics, such as sevoflurane and propofol. This study was aimed to address this issue using network meta-analysis of relevant randomized controlled trials. Summary effect sizes were calculated as odds ratios（ORs）with 95％ confidence intervals（CIs）. The incidence of PONV after administration of different anesthetics was compared by surface under the cumulative ranking curve（SUCRA）analysis. The odds of desflurane vs sevoflurane, desflurane vs propofol, and sevoflurane vs propofol contributing to the incidence of PONV were 0.44（95％ CI, 0.12-1.61）, 2.43（95％ CI, 0.72-8.26）, and 5.50（95％ CI, 1.78-16.93）, respectively. The SUCRA scores for desflurane, sevoflurane, and propofol were 48.3, 5.6, and 96.1, respectively. The incidence of PONV after desflurane administration did not differ significantly from that after sevoflurane and propofol administration. However, the odds of PONV occurring after sevoflurane administration were significantly higher than those after propofol administration. Moreover, the SUCRA score after desflurane administration was greater than that after sevoflurane administration. These results confirm the safety of desflurane regarding PONV in patients undergoing laparoscopic surgery under general anesthesia