HIF-1 response to exposure to high altitude in No-AMS and AMS+ groups.

* Significant difference between AMS and No-AMS groups, ** Significant different vs. Sea level, # Significant different vs. 1 h after exposure to high altitude. Sig≤0.05, values are Mean±SD.</p

ELISA data set of Orexin, HIF-1, VEGF and Endothelin-1.

ELISA data set of Orexin, HIF-1, VEGF and Endothelin-1.</p

SpO₂ changes in response to exposure to high altitude in No-AMS and AMS+, * show significant difference between AMS+ and No-AMS groups.

SpO2 changes in response to exposure to high altitude in No-AMS and AMS+, * show significant difference between AMS+ and No-AMS groups.</p

VEGF response to exposure to high altitude in No-AMS and AMS+ groups.

* Significant difference between AMS and No-AMS groups, ** Significant different vs. Sea level, # Significant different vs. 1 h after exposure to high altitude. Sig≤0.05, values are Mean±SD.</p

Orexin-A response to exposure to high altitude in No-AMS and AMS+ groups.

* Significant difference between AMS and No-AMS groups, ** Significant different vs. Sea level, # Significant different vs. 1 h after exposure to high altitude. Sig≤0.05, values are Mean±SD.</p

Lake Louise score after exposure to high altitude (3550 m).

Lake Louise score after exposure to high altitude (3550 m).</p

Baseline characteristics of the subjects.

Acute mountain sickness (AMS) is caused by rapid ascent to altitude (>2500 m) and remains a poorly understood pathophysiological condition. Accordingly, we investigated the relationship between acute exposure to high altitude and hypoxia related biochemical proteins. 21 healthy subjects (Female (8) and male (13), Age: 36.7±8.5, BMI: 23.2±3.1) volunteers participated in this project and fasting blood samples were taken before (sea level) and after 1 and 24-h exposure to high altitude (3,550 m). Blood oxygen saturation (SpO2), AMS status (Lake Louise Score) and serum HIF-1, Endothelin-1, VEGF and Orexin-A were measured (via ELISA) at 1, 6 and 24 h after exposure to high altitude. Pre-ascent measurement of hypoxia related proteins (Orexin-A, HIF-1, VEGF and Endothelin-1) where all significantly (2 levels (77.7±0.4 vs. 83.5±0.3 respectively, p</div

The correlation between hypoxia related proteins with LLS at sea level and 1 and 24 hrs after exposure to high altitude.

The correlation between hypoxia related proteins with LLS at sea level and 1 and 24 hrs after exposure to high altitude.</p

Endothelin-1 response to exposure to high altitude in No-AMS and AMS+ groups.

* Significant difference between AMS and No-AMS groups, ** Significant different vs. Sea level, # Significant different vs. 1 h after exposure to high altitude. Sig≤0.05, values are Mean±SD.</p