Linear Regression Models Used for the Description of Long-Term Epizootic Process in Tuvinian Natural Plague Focus (Karginsk Mezofocus)

The results of modeling showed the dependence of epizootic activity in Tuvinian natural plague focus on climatic conditions (average monthly amount of precipitations in the current year and the preceding four years and temperatures in the current and the preceding three years). The multiple linear regression models were used to predict the activity of zoonosis development within a year. The models obtained by means of stepwise regression were most approximated to the natural zoonotic process. The amount of precipitations in winter months and temperature in spring and summer were of the greatest significance for epizootic activity

The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination pattern

The extent and patterns of linkage disequilibrium (LD) determine the feasibility of association studies to map genes that underlie complex traits. Here we present a comparison of the patterns of LD across four major human populations (African-American, Caucasian, Chinese, and Japanese) with a high-resolution single-nucleotide polymorphism (SNP) map covering almost the entire length of chromosomes 6, 21, and 22. We constructed metric LD maps formulated such that the units measure the extent of useful LD for association mapping. LD reaches almost twice as far in chromosome 6 as in chromosomes 21 or 22, in agreement with their differences in recombination rates. By all measures used, out-of-Africa populations showed over a third more LD than African-Americans, highlighting the role of the population's demography in shaping the patterns of LD. Despite those differences, the long-range contour of the LD maps is remarkably similar across the four populations, presumably reflecting common localization of recombination hot spots. Our results have practical implications for the rational design and selection of SNPs for disease association studies

Notes

The linkage disequilibrium maps of three human chromosomes across four populations reflect their demographic history and a common underlying recombination patter