Serum Leptin Levels in Asthma, COPD and Bronchiectasis

KISA, Ucler/0000-0002-8131-6810WOS: 000215591800008Aim: The aim of the present study is to compare body mass indexes (BMI) and serum leptin levels of most frequently observed three chronic airway diseases; namely, Asthma, Chronic Obstructive Pulmonary Disease (COPD) and bronchiectasis. Material and Method: The study included a total of 216 people, 78 asthma, 67 COPD, and 37 bronchiectasis patients who were in stable period and 34 healthy individuals all aged above 18. Control group consisted of non-smokers and non-corticosteroid users. Of all the participants, the blood samples were taken in order to determine serum leptin levels and BMI were calculated, and pulmonary function tests measured at rest. Results: The BMI levels of all the groups was above >25 kg/m2. There were no statistical differences between the control and patient groups with regard to BMI (p>0.05). Comparing patient groups, the BMI of asthma patients was higher than those with COPD and bronchiectasis (29.84 +/- 6.46, 25.78 +/- 4.96, 27.64 +/- 5.19, p=0.0001, p=0.20). FEV1 results of COPD patients were lower than those with asthma and bronchiectasis (63.25 +/- 19.26, 76.73 +/- 20.35, 72.75 +/- 20.17 and p=0.0001, p=0.06). Serum leptin levels of asthma patients were higher than the COPD, bronchiectasis patients, as well as that of the control group (12.36 +/- 11.16 ng/ml, 3.35 +/- 4.71 ng/ml, 8.49 +/- 7.85 ng/ml and 5.21 +/- 6.83 ng/ml, p=0.0001, p=0.09 and p=0.0001, respectively). Serum leptin level of COPD patients was lower than control group, but it was not statistically significant (p=0.71). Serum leptin levels of the patients with bronchiectasis were higher than healthy control group members; yet, not statistical significant (p=0.34). However serum leptin levels of the patients with bronchiectasis were higher than the patient COPD groups and this was statisticaly significant (p=0.01). Istatistically significant different emerge on comparing serum leptin levels and BMI of the asthma, COPD and bronchiectasis patients in the Lineear regression analysis made (beta=0.80, p=0.0001, beta=0.32, p=0.006 ve beta=0.82, p=0.0001 respectively). The relation between serum leptin levels and BMI of the healty control group members were not found statistically significant (beta=0.36, p=0.13). Discussion: Among the chronic airway disesases, only in patient with asthma serum leptin levels could be considered and a predictor