51 research outputs found
Activation of the kynurenine pathway and increased production of the excitotoxin quinolinic acid following traumatic brain injury in humans
Neuroprotective effects of intrastriatal injection of rapamycin in a mouse model of excitotoxicity induced by quinolinic acid
Evaluation of Bronchial Inflammatory Response Via Expression of NF-κB & IL-1β in Mice Airways by TAK-242 and LPS Administration: Targeting TLR4/MD2 Signalling Pathway
Optimization of animal model of asthma via toll like receptors-4 (TLR4) activation for bacterial exacerbation of asthma. LPS contributes to asthma exacerbations. Ovalbumin protein sensitization & challenge were examined after LPS exposure. Present research aimed, TLR4 stimulation mediated TLR4/MD2 complex formation is inhibited by TAK-242, a newer compound, for bacterial asthma management in a mouse model. Swiss Albino mice were induced with OVA (10µg, i.p. and 50 µg, i.n.) and LPS (20 µg, i.p. and 4 µg, i.n.), stimulates TLR4 receptor mediated TLR4-MD2 complex formation in toxic groups. Animals were sensitized (i.p.) on 0, 7th and 14th day and challenged (i.n.) followed by TAK-242 treatment (0.1 mg/kg, 1 mg/kg &10 mg/kg i.p.) given on 21st and 22nd days, followed by euthanasia and samples; BALF and lung tissue were collected on 23rd day. Further analysis such as total leukocyte count & differential leukocyte cell count, lung histopathology & immunohistochemistry of NF-κB, proteins like Interleukin-1β in BALF and lungs in toxic, treatment groups in comparison with control group were carried out. TAK-242 reduced TLC/DLC values in BALF, including eosinophil, neutrophil, lymphocyte, macrophage counts, lung histological alterations and immunohistochemical positivity of NF-κB and IL-1β proteins expression. 
Expression of Concern: Role of LOX/COX pathways in 3‐nitropropionic acid‐induced Huntington's Disease‐like symptoms in rats: protective effect of licofelone
Viscosity of high concentration protein formulations of monoclonal antibodies of the IgG1 and IgG4 subclass - Prediction of viscosity through protein-protein interaction measurements
Interfacial Adsorption of a Monoclonal Antibody and Its Fab and Fc Fragments at the Oil/Water Interface
Neurodegeneration Alters Metabolic Profile and Sirt 1 Signaling in High-Fat-Induced Obese Mice
Targeting Neuro-Inflammatory Cytokines and Oxidative Stress by Minocycline Attenuates Quinolinic-Acid-Induced Huntington’s Disease-Like Symptoms in Rats
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