Morphological changes in bone tissue around titanium implants subjected to micro-arc oxidation in alkaline electrolytes with and without the use of «CollapAn-gel»

<p>The purpose of the article is to conduct comparative study of the features of reparative processes in the bone during installation of titanium implants with sandblasted exposed microarc subsequent oxidation in alkaline electrolyte using osteoinductive formulation without the use of this preparation. Material and Methods. Histologically examined tissue samples from 24 adult rabbits in the region of titanium implant with osteoinductive formulation and without after 7, 14, 28, 56 and 112 days postoperatively. Results. It has been revealed that the installation of titanium implants subjected to micro-arc oxidation in alkaline electrolytes without the use of osteoinductive preparation leads to a moderate inflammatory response and the processes of bone formation take more time. When using identical implants with osteoinductive preparation «CollapAn-gel» led to a less expressed inflammatory response and a more active process of bone formation. Conclusion. The use of titanium implants subjected to sandblasting followed microarc oxidation in alkaline electrolytes is optimally combined with osteoinductive agents as it provides the best clinical results and highlights shorter time of bone regeneration.</p

Morphological changes of tissue in implantation of xenopericardium and polypropylene net after surgical intervention

The purpose: Comparative study of rehabilitation processes after implantation of synthetic and biological materials into the tissue of abdominal wall. Materials and Methods: Histological methods have been used to study tissue samples from 15 implantation area of xenopericardial plate and polypropylene net of adult rabbits in 3, 6 and 12 months after the surgery. Results: It has been found out that polypropylene net implantation in the tissue of anterior abdominal wall causes inflammation and growth of connective tissue only around it. Xenopericardial plate implantation is accompanied by lesser inflammation an3 it connects with surrounding connective tissue. Conclusion: It has been revealed that xenopericardium is more likely to use in herniologythan synthetic net. It provides greater mechanical strength of abdominal wall in the later periods after the surgical intervention

The Animalistic Gullet and the Godlike Soul: Reframing Sacrifice in Midrash Leviticus Rabbah

This article proposes an analysis of two homiletic units in the Palestinian Midrash Leviticus Rabbah, which revolve around biblical chapters pertaining to sacrifices. A theme that pervades these units is that of eating as an animalistic activity that often entails moral depravity. In contrast, the act of sacrificing is constructed in these units as one in which one is willing to give up one's own nourishment, and in a sense one's own “soul,” in order to offer it to God. Many of the motifs used to vilify eating in the Midrash can be traced in moralistic Greek, Roman, and early Christian diatribes preaching for moderation in eating or for asceticism; the homilists in Leviticus Rabbah, however, utilize these popular motifs in order to present sacrifice as the spiritual contrary of eating, and thus to give the obsolete practice of sacrifice cultural cachet and compelling meanings

TOWARDS PARTICIPATORY DIGITAL SOCIETY USING THE DIGITAL TWIN PARADIGM: CITIZEN DATA MODEL

Historically, societal challenges have been handled as complicated ones by dividing responsibilities into various organizations that are then mandated to provide needed solutions and services from their own perspective. It has also defined the enterprise architecture that has had a tendency to mimic organizational structures and its responsibilities. Today, modern societies are facing complex challenges, such as climate change, that can’t be solved without a paradigm shift of problem-solving. It also challenges information systems capabilities to co-operate in a cross-sectoral manner. Advances in ICT and its adaptation and penetration rate in every part of society introduce new possibilities that can only be benefitted in full by providing more integrated information systems. Moreover, the level of citizens’ expectation has raised due to other systems that liberally connect data from different sources. To meet new goals, societal services should become more proactive and personalized, satisfying citizens’ needs as they emerge. In this paper, we propose using a holistic model of digital twin paradigm for societal applications. The proposal builds on using a citizen 360-data model that reflects the characteristics of citizens that act as service users. Based on the data model, societal information systems can propose actions and provide proactive services that are mass-tailored to meet individuals’ needs

Male Skeleton from Burial No. 7 of the Mordva-Moksha Bednodemyanovsk Burial Ground of the XIII–XIV Centuries

The article presents the complex characteristic of the skeleton from burial № 7 of the Bednodemyanovsk burial ground of the Mordva-Moksha. The archeological site is dated to the Golden Horde period (XIII–XIV centuries) and is located in Upper Moksha river. The skeleton belonged to the man aged 35–55 years. The aim of the study was to make the most complete reconstruction of the morphological specifics of the individual and his life activity. For this purpose, the bones were carefully studied visually and metrically. Cone beam computed tomography was performed on a VATECH PAX 1 3D device with Ez3D-i64 software. The approximate body length of the individual was determined (about 169.0 cm). The longitudinal measurements of the long tubular bones were the base for it. The skeleton showed multiple traces of pathological changes and indicators of mechanical stress. The individual (apparently in infancy) had the foot trauma. The fracture of the right clavicle in the middle third of the body was in adulthood. A specific characteristic of the individual was spastic contraction of the facial muscles of the lower right side of the face, possibly as a result of facial nerve injury. It was habitual for the individual to move with tensely flexed legs. This may have been related to labor activity or may have been the result of pathology. The characteristic structure of the sternum suggests that the individual was engaged in heavy lifting using a strap across the chest. The arms were slightly bent at the forearms to hold the weight. The hands were tensely flexed at the same time. The study of the skeleton from burial № 7 will let know the lot about the life of the medieval Mordvins and the level of medicine of that time

Injuries and Diseases of the Population of the Upper Sura and Moksha Rivers in the 17th–18th CC

The article characterizes the anthropological materials with traces of pathological changes. All material has been discovered in the territory of the Upper Sura and Moksha rivers, and dated the 17th-18th centuries. Two osteological collections from older cemeteries were studied. The first collection was found in the territory of Penza city, and the second collection was found discovered in Narovchat town. Traces of post-traumatic changes are often identified on the bones. They are localized on the cranial vault, in the orbit region, etc. Traces of fractures on the clavicles are often revealed. Traces of oncology disease are relatively rare. There are nu­merous bones with traces of syphilis pathological changes in the materials from the territory of Penza. These traces are discovered on the skulls and bones of the postcranial skeleton (mostly the tibia). The materials from Narovchat feature two skulls with tooth incision pathologies. In one case, there were signs of anomalies in the development of pelvic bones as a result of rhizomelic spondylitis

Use of National Standards to Monitor HIV Care and Treatment in a High Prevalence City-Washington, DC.

We sought to benchmark the quality of HIV care being received by persons living with HIV in care in Washington, DC and identify individual-level and structural-level differences. Data from the DC Cohort, an observational HIV cohort of persons receiving outpatient care in DC, were used to estimate the Institute of Medicine (IOM) and Department of Health and Human Services (HHS) quality of care measures. Differences in care by demographics and clinic type were assessed using χ2 tests and multivariable regression models. Among 8,047 participants, by HHS standards, 69% of participants were retained in care (RIC), 95% were prescribed antiretroviral therapy (ART), and 84% were virally suppressed (VS). By IOM standards, 84% were in continuous care; and 78% and 80% underwent regular CD4 and VL monitoring, respectively. Screening for syphilis, chlamydia, and gonorrhea was 51%, 31%, and 26%, respectively. Older participants were 1.5 times more likely to be RIC compared to younger participants (OR: 1.5; 95% CI: 1.3, 1.8). Participants enrolled in community-based clinics were more likely to be RIC (OR: 1.7; 95% CI: 1.4, 2.0) versus those enrolled at hospital-based clinics. Older participants were more likely to achieve VS than younger participants (OR: 1.8; 95% CI: 1.5, 2.2) while Black participants were less likely compared to white participants (OR: 0.4; 95% CI: 0.3, 0.5). Despite high measures of quality of care, disparities remain. Continued monitoring of the quality of HIV care and treatment can inform the development of public health programs and interventions to optimize care delivery

Association between the luteinizing hormone/chorionic gonadotropin receptor (LHCGR) rs4073366 polymorphism and ovarian hyperstimulation syndrome during controlled ovarian hyperstimulation

Background The aim of this study was to determine the relationship between a purported luteinizing hormone/chorionic gonadotropin (LHCGR) high function polymorphism (rs4539842/insLQ) and outcome to controlled ovarian hyperstimulation (COH). Methods This was a prospective study of 172 patients undergoing COH at the Fertility and IVF Center at GWU. DNA was isolated from blood samples and a region encompassing the insLQ polymorphism was sequenced. We also investigated a polymorphism (rs4073366 G \u3e C) that was 142 bp frominsLQ. The association of the insLQ and rs4073366 alleles and outcome to COH (number of mature follicles, estradiol level on day of human chorionic gonadotropin (hCG) administration, the number of eggs retrieved and ovarian hyperstimulation syndrome (OHSS)) was determined. Results Increasing age and higher day 3 (basal) FSH levels were significantly associated with poorer response to COH. We found that both insLQ and rs4073366 were in linkage disequilibrium (LD) and no patients were homozygous for both recessive alleles (insLQ/insLQ; C/C). The insLQ variant was not significantly associated with any of the main outcomes to COH. Carrier status for the rs4073366 C variant was associated (P = 0.033) with an increased risk (OR 2.95, 95% CI = 1.09-7.96) of developing OHSS. Conclusions While age and day 3 FSH levels were predictive of outcome, we found no association betweeninsLQ and patient response to COH. Interestingly, rs4073366 C variant carrier status was associated with OHSS risk. To the best of our knowledge, this is the first report suggesting thatLHCGR genetic variation might function in patient risk for OHSS

Incident obstructive lung disease and mortality among people with HIV and a history of injecting drugs

Objective:People with HIV (PWH) experience increased prevalence of obstructive lung disease (OLD), regardless of greater observed smoking behaviors. We investigated whether the effect of incident OLD on mortality differed by HIV and HIV viral suppression among persons who inject drugs (PWID) and report smoking history.Design:ALIVE is a longitudinal, observational cohort study of HIV-positive and seronegative PWID. This analysis included participants who had at least one spirometry measure to assess OLD between 2007 and 2016, excluding those who never smoked (5%, n = 62) or had baseline OLD (17%, n = 269).Methods:Incident OLD occurred when the first prebronchodilator forced expiratory volume in one second (FEV1)/forced vital capacity (FVC) less than 0.70 during follow-up. The effect of incident OLD on all-cause mortality was estimated in PWH and seronegative participants using inverse-probability-of-treatment-weighted marginal structural models controlling for baseline (age, race, sex, calendar year, smoking pack-years) and time-varying (smoking intensity, viral suppression, and calendar time) confounders.Results:Among 1204 participants, 269 (22.3%) and 157 (13.0%) experienced incident OLD and death, respectively, over a median of five person-years of follow-up. There was no effect of OLD on mortality among seronegative participants [hazard ratio = 0.84, 95% confidence interval (CI): 0.47-1.48]; however, PWH diagnosed with OLD experienced an increased mortality risk (hazard ratio = 1.71, 95% CI: 1.04-2.80) during follow-up. HIV viral suppression did not confound or modify the effect of OLD on mortality among PWH.Conclusion:There was an apparent effect of OLD on all-cause mortality irrespective of viral suppression among PWH but not among seronegative persons, after accounting for baseline and time-varying confounders. These results highlight the need for enhanced screening and management of OLD among PWH