The parallax distorsion via a weak microlensing effect

Parallax measurements allow distances to celestial objects to be determined. Coupled with measurement of their position on the celestial sphere, it gives a full three-dimensional picture of the location of the objects relative to the observer. The distortion of the parallax value of a remote source affected by a weak microlensing is considered. This means that the weak microlensing leads to distortion of the distance scale. It is shown that the distortions to appear may change strongly the parallax values in case they amount to several microseconds of arc. In particular, at this accuracy many measured values of the parallaxes must be negative.Comment: 34 LaTeX pages, 12 PostScript figure (epsfig.sty

Microarcsecond instability of the celestial reference frame

The fluctuation of the angular positions of reference extragalactic radio and optical sources under the influence of the irregular gravitational field of visible Galactic stars is considered. It is shown that these angular fluctuations range from a few up to hundreds of microarcseconds. This leads to a small rotation of the celestial reference frame. The nondiagonal coefficients of the rotation matrix are of the order of a microarcsecond. The temporal variation of these coefficients due to the proper motion of the foreground stars is of the order of one microsecond per 20 years. Therefore, the celestial reference frame can be considered inertial and homogeneous only to microarcsecond accuracy. Astrometric catalogues with microarcsecond accuracy will be unstable, and must be reestablished every 20 years.Comment: 5 pages, 2 figures, accepted to MNRA

Methodological aspects of the use of dry components of chicken eggs for feeding children with phenylketonuria

Currently, one of the most important tasks facing science and production is the creation of functional product technologies for use in different diets of the population in order to preserve and improve health, as well as reduce the risks and consequences of various diseases, including hereditary ones, such as phenylketonuria (PKU). The All-Russian Research Institute of Starch Products develops technologies for the production of low-protein starch-based products/semi-products enriched with functional ingredients and intended for therapeutic nutrition of patients with PKU. As part of the pilot production, the production of these products is organized. Purpose of work:to justify the possibility of using dry components of chicken eggs (melange, protein, yolk) to enrich low-protein starch products (noodles, vermichel, «spider») intended for feeding children over 3 years old with phenylketonuria;evaluate organoleptic properties and efficiency of low-protein starch products enriched in hypophenylalanine diet of patients with phenylketonuria older than 3 years

Medico-social rationale for adaptation of regional drug supply systems to personalized pharmaceutical care for persons of different ages

In this study, we identified indicators of the state of personalized pharmaceutical care for target population groups at the regional level, in a model region, with the aim to develop a differentiated approach to such care. The rationale for the choice of Moscow Region as a model region is based on its specific socioeconomic indicators and a comparison of these with respective average Russian values. A need was shown to modernize patient-oriented pharmaceutical care, especially for certain population groups, such as children, women of working age (mothers), and the elderl

БИБЛИОТЕРАПИЯ КАК ЭФФЕКТИВНЫЙ МЕТОД РАБОТЫ С ДЕПРЕССИВНЫМИ СОСТОЯНИЯМИ

The article reveals the problem of depressive states of young students and its relevance today in the work of the psychological and pedagogical service of the university. Bibliotherapy is presented as one of the effective art-therapeutic methods in work with depressive states. Two directions of bibliotherapy on the degree of client involvement in the psychothe­rapeutic process are presented. The diagnostic and therapeutic potential of bibliotherapy is described. An attempt has been made to describe the use of bibliotherapy in working with depressive states of modern students.В статье раскрыта проблема депрессивных состояний учащейся молодежи и ее актуальность на сегодняшний день в работе психолого-педагогической службы вуза. Библиотерапия представлена, как один из эффективных арт-терапевтических методов в работе с депрессивными состояниями. Представлено два направления библиотерапии по степени включенности клиента в психотерапевтический процесс. Описан диагностический и терапевтический потенциал библиотерапии. Предпринята попытка описания использования библиотерапии в работе с деприссивными состояниями современной учащейся молодежи

THE MODERN CONCEPTIONS ABOUT IMMUNOPATHOGENESIS OF INFECTION CAUSED BY THE EPSTEIN–BARR VIRUS

Abstract. The current review summarizes modern data about structural and functional organization of the Epstein–Barr virus (EBV) and stages of its reproduction. The information concerning immune pathogenesis and clinical features of infection caused by EBV and EBV-associated diseases is presented in the article

Tyrosine hydroxylase of the brain and it’s regulation by glucocorticoids

Early life stress events can produce long-lasting changes in neurochemistry and behaviors related to monoamine systems, with increased risks of cardiovascular, metabolic, neuroendocrine, psychiatric disorders, generalized anxiety and depression in adulthood. Tyrosine hydroxylase (TH), the key enzyme for catecholamine synthesis, also plays an important role in the activity of the noradrenergic system and may be a target for glucocorticoids during the perinatal programming of physiological functions and behavior. Administration of hydrocortisone or dexamethasone to female rats on day 20 of pregnancy and to 3-day-old neonatal pups significantly increased TH mRNA levels (real-time PCR) and enzyme activity as well as protein levels determined by ICH in the locus coeruleus. Moreover, our treatment led to increase in TH mRNA levels in 25- and 70-day-old animals, as well as an increase in enzyme activity in the brainstem and cerebral cortex of adult rats. The long-term changes in TH expression are limited by the perinatal period of development. Administration of hormones on day 8 of life was not accompanied by changes in TH mRNA levels or enzyme activity. Glucocorticoids use several mechanisms to bring about transactivation or transrepression of genes. The main mechanism includes direct binding of the hormone-activated GRs to glucocorticoid responsive elements (GREs) in the promoter region of genes. However, despite optimistic claims made the classical GRE was not found in the TH gene promoter. Protein – protein interactions between hormone-activated GR and other transcription factors, for example, AP-1, provide an additional mechanism for the effects of glucocorticoids on gene expression. An important feature of this mechanism is its dependence on the composition of proteins formed by AP-1. Hormone-activated GRs are able to enhance gene expression when AP-1 consists of the Jun / Jun homodimer, but do not do that when AP-1 appears as the Jun / Fos heterodimer. Furthermore, as has been shown recently, the GRE / AP-1 composite site is the major site of interaction of glucocorticoids with  the TH gene in the pheochromocytoma cell line. Ontogenetic variation in the expression of Fos and Jun family proteins, which affects their ratio, can be one of the reasons for the TH gene regulation by glucocorticoids at near-term fetuses and neonates. However, to date this hypothesis has been supported only by in vitro data, and the existence of this mechanism in in vivo conditions needs to be explored in further studies