GENETIC POTENTIAL OF APPLE-TREE BREEDING IN THE SOUTH OF WEST SIBERIA

The results of apple breeding in the south of West Siberia according to the main economically useful features are presented in the paper. On the basis of hybridological analysis, 30 donors and sources of high winter hardiness, 16 sources of polygenic scab resistance and 13 heterozygous sources of monogenic resistance as well as productive varietal samples for breeding for yield and high fruit quality have been selected. Brief characteristics of 34 apple varieties of Gorno-Altaisk breeding are given

Medico-social rationale for adaptation of regional drug supply systems to personalized pharmaceutical care for persons of different ages

In this study, we identified indicators of the state of personalized pharmaceutical care for target population groups at the regional level, in a model region, with the aim to develop a differentiated approach to such care. The rationale for the choice of Moscow Region as a model region is based on its specific socioeconomic indicators and a comparison of these with respective average Russian values. A need was shown to modernize patient-oriented pharmaceutical care, especially for certain population groups, such as children, women of working age (mothers), and the elderl

Prognosis of Adverse Outcomes in the Research of Coronary Blood Flow During Echocardiography

Aim. The goals of this research are to define the frequency of the coronary arteries visualization possibilities depending on various factors at routine echocardiography and estimate to the relation of coronary flow ultrasound parameters to prognosis of the adverse outcomes in the subsequent year.Material and methods. The study comprises 581 consecutive patients. All patients performed echocardiography following standard method with an additional tab called «Coronary» which was set to visualize coronary arteries. Also all patients underwent a standard examination and debriefing of anamnesis. Observation of patients was the next year after echocardiography. The end points in the study – death from any cause, myocardial infarction (MI), death/ MI, myocardial revascularization operations - stenting and aortocoronary bypass (CABG). The analysis of clinical outcomes was carried out using the study of medical history and outpatient cards, interviewing patients at the time of admission, as well as the method of telephone survey of patients or their next of kin. ROC analysis as well as subgroup survival analysis using the Kaplan-Meier method was performed.Results. The possibility to visualize the segments of coronary arteries and to estimate the coronary flow was in 91% of cases, or 526 patients. Women predominated among the patients (59.7% versus 40.3%). During follow-up, 73 patients recorded endpoints: 23 people died, 4 patients suffered non-fatal MI. 24 patients underwent CABG, 22 patients – myocardial revascularization. Depending on the quartile distribution by body mass index and age, a significant difference in visualization was not identified. Mortality was observed significantly more frequent when the flow velocity in the left coronary artery/proximal left artery descending/circumflex artery was higher than 64 cm/s. Flow velocity in left coronary artery /proximal left artery descending 64 cm/s was the cut-off value predicting MI with 100% sensitivity, 73,4% specificity (p<0.0001). Conclusion. Coronary flow velocity parameters provide long-term prognostic value that can be used to identify individuals with high risk of developing adverse cardiovascular events. Key words: coronary flow velocity, echocardiography, coronary artery, adverse events>˂0.0001).Conclusion. Coronary flow velocity parameters provide long-term prognostic value that can be used to identify individuals with high risk of developing adverse cardiovascular events

PROBLEMATICS OF ENTERPRISE DEVELOPMENT IN THE ECONOMY OF KNOWLEDGE BASED ON LOGISTIC APPROACH

The theoretical approach of the knowledge economy to the development of the strategy of industrial enterprises on the basis of the logistical methodology are covered. The definition of strategy and strategic planning for the knowledge economy is presented. The process of strategy development is characterized and the algorithm of strategic planning of an industrial enterprise is proposed taking into account the knowledge economy

History of development of neurosurgery in Scientific Center of Reconstructive and Restorative Surgery SB RAMS - combination of science and practice

The article is devoted to the description of all main milestones of development of neurosurgical ward from the foundation of Scientific Research nstitute of Traumatology and Orthopaedics in İ946 to nowadays. The problems of development of the ward, scientific and practical paradigm of scientific-clinical department of neurosurgery of Scientific Center of Reconstructive and Restorative Surgery SB RAMS are reviewed in the article. The periods of activity of Scientific Research Institute of Traumatology and Orthopaedics from the positions of clinical and scientific achievements are observed. The article presents the facts on the work of clinical and scientific officers that prove close connection of scientific researches and clinical developments in different spheres of neurosurgery. The stages of formation of professional growth of Scientific Research Institute of Traumatology and Orthopaedics in close relation with periods of the development of the country. Also the article presents main dissertation researches performed by the employees of Scientific Research Institute of Traumatology and Orthopaedics, shows their significance in science and clinical work and also illustrates main problems of development of neurosurgery nowadays and determines ways of their solving

INVESTMENTS IN DEVELOPMENT OF SUPPLY CHAINS

The problems of investment in the development of supply chains are considered. The trends that are characteristic of investment processes in the industry are investigated, and problems of investing in the supply chain are highlighted, namely, the lack of a wellcoordinated partnership between the state and private business, underestimation of projects due to incomplete information about the characteristics of investment projects and underdeveloped investment assessment methodology. The authors confirmed the thesis that the development of investment in innovative solutions for supply chains is ensured by more active participation of stakeholders in the investment process