Decision Making: Don't Risk a Delay

Decisions under risk and choices between delayed outcomes are usually treated as two separate problems. A new study suggests that these two classes of decision making are more related than previously thought, and that delay discounting may tune an animal's attitude towards risky choices

Why We Should Use Animals to Study Economic Decision Making – A Perspective

Despite the rich tradition in psychology and biology, animals as research subjects have never gained a similar acceptance in microeconomics research. With this article, we counter this trend of negligence and try to convey the message that animal models are an indispensible complement to the literature on human economic decision making. This perspective review departs from a description of the similarities in economic and evolutionary theories of human and animal decision making, with particular emphasis on the optimality aspect that both classes of theories have in common. In a second part, we outline that actual, empirically observed decisions often do not conform to the normative ideals of economic and ecological models, and that many of the behavioral violations found in humans can also be found in animals. In a third part, we make a case that the sense or nonsense of the behavioral violations of optimality principles in humans can best be understood from an evolutionary perspective, thus requiring animal research. Finally, we conclude with a critical discussion of the parallels and inherent differences in human and animal research

Neural Signatures of Intransitive Preferences

It is often assumed that decisions are made by rank-ordering and thus comparing the available choice options based on their subjective values. Rank-ordering requires that the alternatives’ subjective values are mentally represented at least on an ordinal scale. Because one alternative cannot be at the same time better and worse than another alternative, choices should satisfy transitivity (if alternative A is preferred over B, and B is preferred over C, A should be preferred over C). Yet, individuals often demonstrate striking violations of transitivity (preferring C over A). We used functional magnetic resonance imaging to study the neural correlates of intransitive choices between gambles varying in magnitude and probability of financial gains. Behavioral intransitivities were common. They occurred because participants did not evaluate the gambles independently, but in comparison with the alternative gamble presented. Neural value signals in prefrontal and parietal cortex were not ordinal-scaled and transitive, but reflected fluctuations in the gambles’ local, pairing-dependent preference-ranks. Detailed behavioral analysis of gamble preferences showed that, depending on the difference in the offered gambles’ attributes, participants gave variable priority to magnitude or probability and thus shifted between preferring richer or safer gambles. The variable, context-dependent priority given to magnitude and probability was tracked by insula (magnitude) and posterior cingulate (probability). Their activation-balance may reflect the individual decision rules leading to intransitivities. Thus, the phenomenon of intransitivity is reflected in the organization of the neural systems involved in risky decision-making

Integrating Early Results on Ventral Striatal Gamma Oscillations in the Rat

A vast literature implicates the ventral striatum in the processing of reward-related information and in mediating the impact of such information on behavior. It is characterized by heterogeneity at the local circuit, connectivity, and functional levels. A tool for dissecting this complex structure that has received relatively little attention until recently is the analysis of ventral striatal local field potential oscillations, which are more prominent in the gamma band compared to the dorsal striatum. Here we review recent results on gamma oscillations recorded from freely moving rats. Ventral striatal gamma separates into distinct frequency bands (gamma-50 and gamma-80) with distinct behavioral correlates, relationships to different inputs, and separate populations of phase-locked putative fast-spiking interneurons. Fast switching between gamma-50 and gamma-80 occurs spontaneously but is influenced by reward delivery as well as the application of dopaminergic drugs. These results provide novel insights into ventral striatal processing and highlight the importance of considering fast-timescale dynamics of ventral striatal activity

Distinct Profiles of 50 kHz Vocalizations Differentiate Between Social Versus Non-social Reward Approach and Consumption

Social animals tend to possess an elaborate vocal communication repertoire, and rats are no exception. Rats utilize ultrasonic vocalizations (USVs) to communicate information about a wide range of socially relevant cues, as well as information regarding the valence of the behavior and/or surrounding environment. Both quantitative and qualitative acoustic properties of these USVs are thought to communicate context-specific information to conspecifics. Rat USVs have been broadly categorized into 22 and 50 kHz call categories, which can be further classified into subtypes based on their sonographic features. Recent research indicates that the 50 kHz calls and their various subtype profiles may be related to the processing of social and non-social rewards. However, only a handful of studies have investigated USV elicitation in the context of both social and non-social rewards. Here, we employ a novel behavioral paradigm, the social-sucrose preference test, that allowed us to measure rats’ vocal responses to both non-social (i.e., 2, 5, and 10% sucrose) and social reward (interact with a Juvenile rat), presented concurrently. We analyzed adult male Long-Evans rats’ vocal responses toward social and non-social rewards, with a specific focus on 50 kHz calls and their 14 subtypes. We demonstrate that rats’ preference and their vocal responses toward a social reward were both influenced by the concentration of the non-social reward in the maze. In other words, rats showed a trade-off between time spent with non-social or social stimuli along with increasing concentrations of sucrose, and also, we found a clear difference in the emission of flat and frequency-modulated calls in the social and non-social reward zones. Furthermore, we report that the proportion of individual subtypes of 50 kHz calls, as well as the total USV counts, showed variation across different types of rewards as well. Our findings provide a thorough overview of rat vocal responses toward non-social and social rewards and are a clear depiction of the variability in the rat vocalization repertoire, establishing the role of call subtypes as key players driving context-specific vocal responses of rats

The role of the avian prefrontal cortex (Nidopallium Caudolaterale) in decision-making

Impulsivität und Selbstkontrolle sind zwei antagonistische Entscheidungsdispositionen. In dieser Dissertation wurde die neuronale Basis untersucht, die dieser Art von Wahlverhalten bei Tauben zugrunde liegt. In der ersten Studie wurde gezeigt, daß das Nidopallium caudolaterale (NCL), der Präfrontalkortex von Vögeln, eine Rolle bei der Generierung von belohnungsabhängigen Entscheidungsmustern spielte. In einer zweiten Studie wurden Einzelzellen im NCL identifiziert, die den zeitlich devaluierten subjektiven Belohnungswert bei impulsiven Entscheidungen repräsentierten. Zwei weitere Experimente belegten die Bedeutung des NCLs für Verhaltenskontrolle: NCL Neurone spiegelten die Strategie der passiven Antwortunterdrückung in einem Go-NoGo Task, und reflektierten die zeitliche Planung einer Reaktionsinhibition bei aktiver Verhaltenskontrolle. Diese vier Studien belegen, daß das NCL Teil eines Netzwerks zur Bildung und Kontrolle von impulsiven und selbstkontrollierten Entscheidungen ist.Impulsivity and self-control are two antagonistic choice dispositions. In this thesis, the neural basis underlying this type of decision-making in pigeons was investigated. The first study revealed that the nidopallium caudolaterale (NCL), the avian prefrontal cortex, was relevant for generating reward-related choice patterns. A second study showed that single NCL neurons represented the temporally discounted subjective reward values during impulsive decision making. Two follow-up experiments indicated that the NCL was also involved in action control. NCL neurons mirrored the animals default response omission strategy in a delayed Go-NoGo task, and single cells also reflected the temporal scheduling of the response suppression in an active response inhibition task. In conclusion, this thesis has shown that the NCL plays a role in both making and controlling appropriate decisions, and is thus part of a network involved in generating impulsive and self-controlled choice behaviour

Variations in progesterone and estradiol across the menstrual cycle predict generosity toward socially close others

The human tendency to share goods with others at personal costs declines across the perceived social distance to them, an observation termed social discounting. Cumulating evidence suggests that social preferences are influenced by the agent's neurohormonal state. Here we tested whether endogenous fluctuations in steroid hormone compositions across the menstrual cycle were associated with differences in generosity in a social discounting task. Adult healthy, normally-cycling, women made incentivized decisions between high selfish rewards for themselves and lower generous rewards for themselves but also for other individuals at variable social distances from their social environment. We determined participants' current levels of menstrual-cycle-dependent steroid hormones via salivary sampling. Results revealed that the increase in progesterone levels as well as the decrease in estradiol levels, but not changes in testosterone or cortisol, across the menstrual cycle, accounted for increased generosity specifically toward socially close others, but not toward remote strangers

Influence of memory processes on choice consistency

Choice-consistency is considered a hallmark of rational value-based choice. However, because the cognitive apparatus supporting decision-making is imperfect, real decision-makers often show some degree of choice inconsistency. Cognitive models are necessary to complement idealized choice axioms with attention, perception and memory processes. Specifically, compelling theoretical work suggests that the (imperfect) retention of choice-relevant memories might be important for choice-consistency, but this hypothesis has not been tested directly. We used a novel multi-attribute visual choice (MAVC) paradigm to experimentally test the influence of memory retrieval of exemplars on choice-consistency. Our manipulation check confirmed that our retention interval manipulation successfully reduced memory representation strength. Given this, we found strong evidence against our hypothesis that choice-consistency decreases with increasing retention time. However, quality controls indicated that the choice-consistency of our participants was non-discernable from random behavior. In addition, an exploratory analysis showed essentially no test-retest reliability of choice-consistency between two observations. Taken together, this suggests the presence of a floor effect in our data and, thus, low data quality for conclusively evaluating our hypotheses. Further exploration tentatively suggested a high difficulty of discriminating between the choice objects driving this floor effect