Сравнительная оценка эффективности и безопасности внутрисуставного введения препаратов гиалуроновой кислоты и глюкокортикоидов в комплексной терапии остеоартрита

Improving the treatment of knee (KN) osteoarthritis (OA) remains an urgent problem.Objective: to compare the efficacy and tolerability of intra-articular (i/a) administration of long-acting glucocorticoids (GCs) and Armaviscon®Forte and Armaviscon®Platinum hyaluronates in patients with knee OA.Material and methods. From November 2019 to April 2022, we examined and treated 60 patients (26 men and 34 women, mean age 41.32±3.71 years) suffering from primary KN OA. Study participants were randomly divided into three groups of 20 patients each. In the 1st group, a longacting GCs in combination with a local anesthetic was administered once i/a into the KN, in the 2nd – Armaviscon®Forte 2.3%, and in the 3rd – Armaviscon®Platinum 3%.Patients were examined at baseline, on the 14th and 60th day after a single injection of the drug. The intensity of pain was assessed on a visual analog scale (VAS), the Lequesne index, the KOOS, WOMAC, and EQ-5D questionnaires were used. When studying tolerability, the number of adverse reactions (ARs) was taken into account.Results. By the end of the observation period in the study groups, there was a decrease in the severity of pain and an increase in functionality with positive dynamics of the Lequesne and WOMAC indices. Both hyaluronic acid drugs had a positive effect on the functional state of the joints according to KOOS, improved the quality of life according to EQ-5D. The need for non-steroidal anti-inflammatory drugs in patients of the 2nd and 3rd groups decreased down to their complete cancellation. No adverse events requiring discontinuation of therapy have been reported. The advantage of i/a administration of hyaluronates in comparison with long-acting GCs was shown.Conclusion. In real clinical practice, in patients with symptomatic OA, i/a administration of hyaluronates allows obtaining more favorable results than the use of long-acting HA.Совершенствование терапии остеоартрита (ОА) коленных суставов (КС) остается актуальной проблемой.Цель исследования – сравнительная оценка эффективности и переносимости внутрисуставного (в/с) введения глюкокортикоидов (ГК) пролонгированного действия и гиалуронатов Армавискона®Форте и Армавискона®Platinum у пациентов с ОА КС.Материал и методы. С ноября 2019 г. по апрель 2022 г. проведено обследование и лечение 60 пациентов (26 мужчин и 34 женщин, средний возраст – 41,32±3,71 года), страдающих первичным ОА КС. Участники исследования были случайным образом разделены на три группы по 20 больных. В 1-й группе в КС однократно вводился ГК пролонгированного действия в сочетании с местным анестетиком, во 2-й – Армавискон®Форте 2,3%, а в 3-й – Армавискон®Platinum 3%. Пациентов обследовали исходно, на 14-й и 60-й дни после однократного введения препарата. Оценивалась интенсивность боли по визуальной аналоговой шкале, использовался индекс Лекена, опросники KOOS, WOMAC и EQ-5D. При изучении переносимости учитывали число неблагоприятных реакций (НР).Результаты и обсуждение. К моменту завершения наблюдения в исследуемых группах отмечались уменьшение выраженности боли и расширение функциональных возможностей с положительной динамикой индексов Лекена и WOMAC. Оба препарата гиалуроновой кислоты оказывали положительное влияние на функциональное состояние суставов по KOOS, улучшали качество жизни по EQ-5D. Потребность в нестероидных противовоспалительных препаратах у пациентов 2-й и 3-й групп уменьшалась вплоть до полной их отмены. НР, требующие прекращения терапии, не зарегистрированы. Показано преимущество в/с введения гиалуронатов по сравнению с ГК пролонгированного действия.Заключение. В реальной клинической практике у пациентов с симптоматическим ОА в/с введение гиалуронатов позволяет получать более благоприятные результаты, чем использование ГК пролонгированного действия

Biodiversity surveys of grassland and coastal habitats in 2021 as a documentation of pre-war status in southern Ukraine

Background This paper presents two sampling-event datasets with occurrences of vascular plants, bryophytes and lichens collected in May-June 2021 in southern Ukraine. We aimed to collect high-quality biodiversity data in an understudied region and contribute it to international databases and networks. The study was carried out during the 15th Eurasian Dry Grassland Group (EDGG) Field Workshop in southern Ukraine and the Dark Diversity Network (DarkDivNet) sampling in the Kamianska Sich National Nature Park. By chance, these datasets were collected shortly before the major escalation of the Russian invasion in Ukraine. Surveyed areas in Kherson and Mykolaiv Regions, including established monitoring plots, were severely affected by military actions in 2022. Therefore, collected data are of significant value in the context of biodiversity documentation. The knowledge about the biodiversity of this area will help to assess the environmental impact of the war and plan restoration of the damaged or destroyed habitats. The first preliminary analysis of collected data demonstrates the biodiversity richness and conservation value of studied grassland habitats. New information We provide sampling-event datasets with 7467 occurrences, which represent 708 taxa (vascular plants, bryophytes and lichens) collected in 275 vegetation relevés. Amongst them, vascular plants are represented by 6665 occurrences (610 taxa), lichens - 420 (46) and bryophytes - 381 (51). Several new species were reported for the first time at the national or regional level. In particular, one vascular plant species (Torilis pseudonodosa) and two lichen species (Cladonia conista, Endocarpon loscosii) were new to Ukraine. One vascular plant (Stipa tirsa), two species of bryophytes (Rhynchostegium megapolitanum, Ptychostomum torquescens) and three species of lichens (Cladonia cervicornis, C. symphycarpa, Involucropyrenium breussi) were recorded for the first time for the Kherson Region. Additionally, these datasets contain occurrences of taxa with narrow distribution, specialists of rare habitat types and, therefore, represented by a low number of occurrences in relevant biodiversity databases and particularly in GBIF. This publication highlights the diversity of natural vegetation and its flora in southern Ukraine and raises conservation concerns