6 research outputs found
Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis‑associated bone loss: a prospective cohort study
The potential link between infection with Chlamydia
pneumoniae or Helicobacter pylori and osteoporosis
has not been investigated in population-based longitudinal
studies. A total of 250 healthy postmenopausal women
who participated in a prospective cohort study were evaluated
for IgG antibodies directed against C. pneumoniae and
H. pylori, osteoprotegerin (OPG), the receptor activator of
nuclear factor kappa B ligand (RANKL), CrossLaps, and
osteocalcin. Bone mineral density (BMD) was measured at
the femoral neck and lumbar spine at baseline and at follow-
up 5.8 years later. There were no significant differences
in age-adjusted bone turnover markers, OPG, RANKL,
the RANKL/OPG ratio, and BMD between the C. pneumoniae
and H. pylori IgG seropositive and seronegative
subjects (P > 0.05). Neither C. pneumoniae nor H. pylori
IgG seropositivity was associated with age-and body mass index-adjusted BMD at the femoral neck and lumbar spine
or bone loss at the 5.8-year follow-up. In logistic regression
analysis, neither C. pneumoniae nor H. pylori IgG seropositivities
predicted incident lumbar or spine osteoporosis
5.8 years later. In conclusion, neither C. pneumoniae nor
H. pylori IgG seropositivity was associated with bone turnover
markers, the RANKL/OPG ratio, BMD, or bone loss
in postmenopausal women. In addition, chronic infection
with C. pneumoniae or H. pylori did not predict incident
osteoporosis among this group of women
The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study
The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the
cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating
levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1,
visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal
women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and
high-sensitivity C-reactive protein (hs-CRP) levels weremeasured with the highly specific enzyme-linked
immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase,
osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized
β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive
correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and
BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes
mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlationswere found between IGF-1, adiponectin,
and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausalwomen
beyondmetabolic syndrome, type 2 diabetes, bone formationmarkers, and hs-CRP levels.
The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a
physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects
Omentin-1, visfatin and adiponectin levels in relation to bone mineral density in Iranian postmenopausal women
The potential link between infection with Chlamydia
pneumoniae or Helicobacter pylori and osteoporosis
has not been investigated in population-based longitudinal
studies. A total of 250 healthy postmenopausal women
who participated in a prospective cohort study were evaluated
for IgG antibodies directed against C. pneumoniae and
H. pylori, osteoprotegerin (OPG), the receptor activator of
nuclear factor kappa B ligand (RANKL), CrossLaps, and
osteocalcin. Bone mineral density (BMD) was measured at
the femoral neck and lumbar spine at baseline and at follow-
up 5.8 years later. There were no significant differences
in age-adjusted bone turnover markers, OPG, RANKL,
the RANKL/OPG ratio, and BMD between the C. pneumoniae
and H. pylori IgG seropositive and seronegative
subjects (P > 0.05). Neither C. pneumoniae nor H. pylori
IgG seropositivity was associated with age-and body massindex-adjusted BMD at the femoral neck and lumbar spine
or bone loss at the 5.8-year follow-up. In logistic regression
analysis, neither C. pneumoniae nor H. pylori IgG seropositivities
predicted incident lumbar or spine osteoporosis
5.8 years later. In conclusion, neither C. pneumoniae nor
H. pylori IgG seropositivity was associated with bone turnover
markers, the RANKL/OPG ratio, BMD, or bone loss
in postmenopausal women. In addition, chronic infection
with C. pneumoniae or H. pylori did not predict incident
osteoporosis among this group of women
Chlamydia pneumoniae and Helicobacter pylori IgG seropositivities are not predictors of osteoporosis‑associated bone loss: a prospective cohort study
The potential link between infection with Chlamydia
pneumoniae or Helicobacter pylori and osteoporosis
has not been investigated in population-based longitudinal
studies. A total of 250 healthy postmenopausal women
who participated in a prospective cohort study were evaluated
for IgG antibodies directed against C. pneumoniae and
H. pylori, osteoprotegerin (OPG), the receptor activator of
nuclear factor kappa B ligand (RANKL), CrossLaps, and
osteocalcin. Bone mineral density (BMD) was measured at
the femoral neck and lumbar spine at baseline and at follow-up
5.8 years later. There were no significant differences
in age-adjusted bone turnover markers, OPG, RANKL,
the RANKL/OPG ratio, and BMD between the C. pneumoniae
and H. pylori IgG seropositive and seronegative
subjects (P > 0.05). Neither C. pneumoniae nor H. pylori
IgG seropositivity was associated with age-and body mass
index-adjusted BMD at the femoral neck and lumbar spine
or bone loss at the 5.8-year follow-up. In logistic regression
analysis, neither C. pneumoniae nor H. pylori IgG seropositivities predicted incident lumbar or spine osteoporosis 5.8 years later. In conclusion, neither C. pneumoniae nor H. pylori IgG seropositivity was associated with bone turnover markers, the RANKL/OPG ratio, BMD, or bone loss
in postmenopausal women. In addition, chronic infection
with C. pneumoniae or H. pylori did not predict incident
osteoporosis among this group of women.
Keywords Chlamydia pneumoniae · Helicobacter
pylori · Bone mineral density · Osteoporosi
Peptide Receptor Radionuclide Therapy Using 177Lu-DOTATATE in Advanced Neuroendocrine Tumors (NETs) in a Limited-Resource Environment
Background This study was conducted to evaluate the clinical efficacy and safety of peptide receptor radionuclide therapy (PRRT) using 177Lu-DOTA0-Tyr3-octreotate (DOTATATE) in patients with neuroendocrine tumors (NETs).
Methods Sixteen patients with pathologically verified NETs including eight females and eight males were enrolled in this study. Before PRRT, the patients underwent 68Ga-DOTATATE positron emission tomography/computed tomography or 99mTc-octreotide scintigraphy for evaluation of somatostatin receptor expression. Response to treatment was assessed according to the Response Evaluation Criteria In Solid Tumors (RECIST) classified as complete response (CR), partial response (PR), stable disease (SD), and progressive disease (PD). In addition, for evaluation of toxicity, monthly blood analysis was performed including hematology, renal function (creatinine) test, and liver function test. The Eastern Cooperative Oncology Group (ECOG) status performance was applied to estimate the patients' general condition in a scale of 0 (fully active) to 5 (dead). In addition, overall survival (OS) was calculated as the time interval from the start of PRRT to death from any reason.
Results Sixteen patients including eight females and eight males with a median age of 60.5 years (range: 24–74) were enrolled in this study. The patients underwent PRRT with a median cycle of 3.5 (range: 1–7) and a median dose of 20.35 (range: 7.4–49.95 GBq). At the end of data collection, PR, CR, SD, and PD were seen in 11, 2, 1, and 2 patients according to the RECIST, respectively. Three patients expired during or after the PRRT period. The median ECOG and Karnofsky Performance Scale was 1.5 and 75 before PRRT, which improved significantly to 1 and 80 after PRRT, respectively (p < 0.05). According to the Kaplan–Meier test, the median OS was 23 months (95% confidence interval: 7.90–38.09). According to the National Cancer Institute's Common Terminology Criteria for Adverse Events, three patients showed grade I and three patients showed grade II leucopenia. Furthermore, three and seven patients had grade II and grade I anemia, respectively.
Conclusion Since PRRT using 177Lu-DOTATATE has a favorable response rate and few adverse effects and improves the quality of life in NETs, it can be used as an effective therapeutic option, especially in nonoperative, metastatic, and progressive NETs
The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study
The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with the highly specific enzyme-linked immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase, osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlations were found between IGF-1, adiponectin, and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausal women beyond metabolic syndrome, type 2 diabetes, bone formation markers, and hs-CRP levels. The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects