The evaluation and management of recurrent abdominal pain in childhood

Recurrent abdominal pain (RAP) is a common complaint in children. Previously considered a single entity, RAP is now used as a descriptive term and sub-classified in the recently published Rome IV criteria, into four functional abdominal pain disorders (FAPD), including functional dyspepsia and irritable bowel syndrome. All share common pathogenic mechanisms of visceral hypersensitivity and central hypervigilance, resulting from disruption of the microbiota–gut–brain axis and abnormal enteric neuro–immune interactions. Although FAPDs are benign in nature, the persistence of symptoms and effects on everyday life can have significant secondary effects including psychosocial morbidity. The diagnosis of FAPDs is based on careful history and examination looking for ‘alarm signs’, although a limited battery of laboratory investigations to screen for organic disease may be of value. The management of FAPDs should be multidisciplinary and based on the bio-psychosocial model of care with careful education and engagement of patients/parents. There is currently little evidence to support the routine use of pharmacotherapy, probiotics or diet and a significant placebo effect should be considered when assessing treatment effect. Hypnotherapy has been shown to be an effective therapy. Approximately 50% of FAPDs cases will achieve resolution, especially those that have engaged with the appropriate model of management

Graft-versus-host disease in paediatric liver transplantation: A review of the literature

Background. Graft versus host disease (GvHD) is a major complication after haematopoietic stem-cell transplantation but much less common after solid organ transplant and rare after liver transplantation. Early symptoms can resemble viral infections or drug-reactions and thus it may be under-investigated. There are no standard treatment guidelines for GvHD after paediatric liver transplantation.Objectives. To review all cases of GvHD reported to date after paediatric liver transplant.Methods. Literature review of all English-language full-text articles published between 1990 and 2017Results. Case series articles and case reports were reviewed and collated. Symptoms, diagnostic investigations, treatments and outcomes were described for all reported cases.Conclusion. GvHD in paediatric liver transplantation is difficult to treat and has a high mortality, but better recognition and understanding with novel therapies available offer hope for the future

Graftversushost disease in paediatric liver transplantation: A review of the literature

Background. Graft versus host disease (GvHD) is a major complication after haematopoietic stem-cell transplantation but much less common after solid organ transplant and rare after liver transplantation. Early symptoms can resemble viral infections or drug-reactions and thus it may be under-investigated. There are no standard treatment guidelines for GvHD after paediatric liver transplantation.Objectives. To review all cases of GvHD reported to date after paediatric liver transplant.Methods. Literature review of all English-language full-text articles published between 1990 and 2017Results. Case series articles and case reports were reviewed and collated. Symptoms, diagnostic investigations, treatments and outcomes were described for all reported cases.Conclusion. GvHD in paediatric liver transplantation is difficult to treat and has a high mortality, but better recognition and understanding with novel therapies available offer hope for the future