High Serum Levels of Procollagen Type III-N-terminal Amino Peptide in Patients with Congenital Heart Disease

Abstract Objective: The serum concentration of amino-terminal procollagen type III (PIIIP) is considered a useful marker of tissue fibrogenesis. The present study tested the hypothesis that: 1) serum PIIIP levels are elevated in patients with congenital heart disease (CHD) and abnormal hemodynamic loading and/or hypoxemia, 2) PIIIP levels are associated with severity of hemodynamic load or hypoxemia, both of which enhance myocardial fibrosis. Methods and Results: Serum PIIIP levels were measured in 5 groups of CHD patients [42 patients with ventricular septal defect (VSD), 26 with coarctation of the aorta (COA, n=19) or aortic stenosis (AS, n=7), 36 with atrial septal defect (ASD), 39 with pulmonary stenosis (PS) and 20 with tetralogy of Fallot (TOF)]. PIIIP levels of CHD patients were significantly higher than those of 42 control subjects (p<0.05, each). Serum PIIIP levels increased in parallel with increased ventricular volume load in VSD and ASD, and with severity of PS. In TOF patients, PIIIP levels correlated negatively with arterial oxygen saturation. Treatment with angiotensin converting enzyme inhibitor (ACEI) was associated with low levels of PIIIP in COA/AS patients despite existing hemodynamic load. Conclusion: The increased serum PIIIP levels in proportion with the severity of ventricular load or cyanosis suggest enhanced myocardial synthesis of collagen type III in patients with CHD. Suppression of PIIIP level by ACEI suggests the involvement of the renin-angiotensin-aldosterone system in myocardial fibrosis. These data provide the basis for the development of new diagnostic and therapeutic strategies in patients with CHD

Research and Design of a Routing Protocol in Large-Scale Wireless Sensor Networks

无线传感器网络，作为全球未来十大技术之一，集成了传感器技术、嵌入式计算技术、分布式信息处理和自组织网技术，可实时感知、采集、处理、传输网络分布区域内的各种信息数据，在军事国防、生物医疗、环境监测、抢险救灾、防恐反恐、危险区域远程控制等领域具有十分广阔的应用前景。 本文研究分析了无线传感器网络的已有路由协议，并针对大规模的无线传感器网络设计了一种树状路由协议，它根据节点地址信息来形成路由，从而简化了复杂繁冗的路由表查找和维护，节省了不必要的开销，提高了路由效率，实现了快速有效的数据传输。 为支持此路由协议本文提出了一种自适应动态地址分配算——ADAR（AdaptiveDynamicAddre...As one of the ten high technologies in the future, wireless sensor network, which is the integration of micro-sensors, embedded computing, modern network and Ad Hoc technologies, can apperceive, collect, process and transmit various information data within the region. It can be used in military defense, biomedical, environmental monitoring, disaster relief, counter-terrorism, remote control of haz...学位：工学硕士院系专业：信息科学与技术学院通信工程系_通信与信息系统学号：2332007115216

Volume Overload and Pressure Overload due to Left-to-Right Shunt-Induced Myocardial Injury: Evaluation Using a Highly Sensitive Cardiac Troponin-I Assay in Children With Congenital Heart Disease (左-右短絡による容量負荷と圧負荷により誘発される心筋障害-高感度心臓トロポニン-I測定を利用した先天性心疾患小児の評価)

雑誌掲載版心臓トロポニンI(cTnI)急性冠症候群や急性心筋梗塞における最も感度と特異度が高い生物標識である。本研究では、小児の心房中隔欠損症(ASD)30例、心室中隔欠損症(VSD)32例と健康小児350例の血清cTnIを測定した。血清cTnIはASD及びVSDの小児では健康小児より有意に高値で(それぞれP<0.05、P<0.01)、VSD小児では血清cTnIは心カテーテル法で測定した肺動脈血/全身動脈圧比と有意の相関があった(r=0.745、P<0.001

Gait oscillation analysis during gait and stair-stepping in elder patients with knee osteoarthritis

Abstract Background Evaluation of knee and lower limb function alone is not sufficient to assess gait. For accurate assessment of gait abnormality, gait oscillation should also be measured. The goal of this analysis was to assess the influence of the knee joint on gait oscillation during gait and stair-stepping in patients with osteoarthritis of the knee. Methods In 33 patients diagnosed with knee osteoarthritis and 33 healthy adults as the control group, we examined acceleration (anterior and lateral directions) and gait barycentric factors (single-support phase and ratio of center of gravity maximum values) during gait and stair-stepping. Results Acceleration in the anterior direction in the sacral region was greater in healthy adults than in osteoarthritis (OA) patients during gait and stair-down. Acceleration in the anterior direction in the dorsal vertebral region was greater in OA patients than in healthy adults during (up and down) stair-stepping. Acceleration in the lateral direction in the sacral region was greater in healthy adults than in OA patients during stair-up. Acceleration in the lateral direction in the dorsal vertebral region was greater in OA patients than in healthy adults during stair-stepping. The single-support phase was close to 1 for gait and stair-stepping in healthy adults and OA patients. The single-support time was largely the same for gait and stair-stepping in healthy adults. On the other hand, the single-support time was longer for stair-stepping than for gait in OA patients. The ratio of the center of gravity maximum values was greater for the sacral region than for the dorsal vertebral region. There was a significant difference in the stair-stepping ratio of the center of gravity maximum values between healthy adults and OA patients for the sacral region. Conclusion We considered that knee OA influenced acceleration in the anterior and lateral direction in the dorsal vertebral and the ratio of the center of gravity maximum values on gait oscillation

The Role of N-Terminal Pro-B-Type Natriuretic Peptide in the Diagnosis of Congestive Heart Failure in Children: Correlation With the Heart Failure Score and Comparison With B-Type Natriuretic Peptide (小児のうっ血性心不全診断におけるN-末端Pro-B型Na利尿ペプチドの役割 心不全評点との相関及びB型Na利尿ペプチドとの比較)

雑誌掲載版うっ血性心不全(CHF)の小児181例と健康小児232例の血漿B型Na利尿ペプチド(BNP)との血清N末端Pro-B型Na利尿ペプチド(NT-ProBNP)を測定した。心不全はRoss評点変法によりI、II、III、IV度に分類した。BNPもNT-ProBNPも心不全重症度が重くなるとともに有意に増加し、BNPとNT-ProBNPの間には高度の正相関があった(r=0.856、P<0.005)。しかし、NT-ProBNPの心不全重症度による分割値を3歳未満と3歳以上とで別々に定めると、受信者動作特性解析による感度、特異度ともBNPよりも有意に良好であった