1 research outputs found
Synthetic Polymer with a Structure-Driven Hepatic Deposition and Curative Pharmacological Activity in Hepatic Cells
Synthetic
polymers make strong contributions as tools for delivery
of biological drugs and chemotherapeutics. The most praised characteristic
of polymers in these applications is complete lack of pharmacological
function such as to minimize the side effects within the human body.
In contrast, synthetic polymers with curative pharmacological activity
are truly rare. Moreover, such activity is typically nonspecific rather
than structure-defined. In this work, we present the discovery of
poly(ethylacrylic acid) (PEAA) as a polymer with a suit of structure-defined,
unexpected, pharmacological, and pharmacokinetic properties not observed
in close structural analogues. Specifically, PEAA reveals capacity
to bind to albumin with ensuing natural hepatic deposition in vivo
and exhibits concurrent inhibitory activity against the hepatitis
C virus and inflammation in hepatic cells. Our findings provide a
view on synthetic polymers as curative, functional agents and present
PEAA as a unique biomedical tool with applications related to health
of the human liver