142 research outputs found

    Asymmetric magnetization splitting in diamond domain structure: Dependence on exchange interaction and anisotropy

    Full text link
    The distributions of magnetization orientation for both Landau and diamond domain structures in nano-rectangles have been investigated by micromagnetic simulation with various exchange coefficient and anisotropy constant. Both symmetric and asymmetric magnetization splitting are found in diamond domain structure, as well as only symmetric magnetization splitting in Landau structure. In the Landau structure, the splitting angle increases with the exchange coefficient but decreases slightly with the anisotropy constant, suggesting that the exchange interaction mainly contributes to the magnetization splitting in Landau structure. However in the diamond structure, the splitting angle increases with the anisotropy constant but derceases with the exchange coefficient, indicating that the magnetization splitting in diamond structure is resulted from magnetic anisotropy.Comment: 5 pages, 5 figure

    Wake‐effect aware optimal online control of wind farms : an explicit solution

    Get PDF
    Wake effects impose significant aerodynamic interactions among wind turbines. To improve the wind farm operating performance, practical wind farm online control considering wake effects becomes very important. To achieve online optimal wind farm control while responding to grid demands, this paper proposes a novel optimal wind farm supervisory control (SC) model and its explicit solutions. From the controller modelling perspective, the two major wind farm operating modes, the maximum power point tracking mode and the set‐point tracking mode, are first analysed and unified in one optimisation model while considering wake effects. In this way, wind farm power production and rotor kinetic energy reserve can be simultaneously considered to conveniently modify the operation mode in response to different grid demands. Aside from controller modelling, the collocation method is first introduced to address the online application problem of such wake‐effect aware optimal WF control. Although a few optimisation algorithms have been proposed to find the optimum offline, online optimal control is still challenging because of the computational complexity brought by wake model non‐linearity and non‐convexity. The proposed collocation method explicitly approximates the optimal solutions to the proposed supervisory control model, through which only a direct algebraic operation is required for online optimal control instead of repeated optimisations. Case studies are carried out on different wind farms under various wind conditions, showing that the wind farm power production potential and releasable power reserve are improved compared to traditional greedy control in both modes. The accuracy of the collocation method is verified. A detailed analysis of the wind farm production capacity under different wind speeds and directions is also provided

    ABCB5+ mesenchymal stromal cells therapy protects from hypoxia by restoring Ca2+ homeostasis in vitro and in vivo

    Get PDF
    Background: Hypoxia in ischemic disease impairs Ca2+ homeostasis and may promote angiogenesis. The therapeutic efficacy of mesenchymal stromal cells (MSCs) in peripheral arterial occlusive disease is well established, yet its influence on cellular Ca2+ homeostasis remains to be elucidated. We addressed the influence of ATP-binding cassette subfamily B member 5 positive mesenchymal stromal cells (ABCB5+ MSCs) on Ca2+ homeostasis in hypoxic human umbilical vein endothelial cells (HUVECs) in vitro and in vivo. Methods: Hypoxia was induced in HUVECs by Cobalt (II) chloride (CoCl2) or Deferoxamine (DFO). Dynamic changes in the cytosolic- and endoplasmic reticulum (ER) Ca2+ and changes in reactive oxygen species were assessed by appropriate fluorescence-based sensors. Metabolic activity, cell migration, and tube formation were assessed by standard assays. Acute-on-chronic ischemia in Apolipoprotein E knock-out (ApoE−/−) mice was performed by double ligation of the right femoral artery (DFLA). ABCB5+ MSC cells were injected into the ischemic limb. Functional recovery after DFLA and histology of gastrocnemius and aorta were assessed. Results: Hypoxia-induced impairment of cytosolic and ER Ca2+ were restored by ABCB5+ MSCs or their conditioned medium. Similar was found for changes in intracellular ROS production, metabolic activity, migratory ability and tube formation. The restoration was paralleled by an increased expression of the Ca2+ transporter Sarco-/endoplasmic reticulum ATPase 2a (SERCA2a) and the phosphorylation of Phospholamban (PLN). In acute-on-chronic ischemia, ABCB5+ MSCs treated mice showed a higher microvascular density, increased SERCA2a expression and PLN phosphorylation relative to untreated controls. Conclusions: ABCB5+ MSCs therapy can restore cellular Ca2+ homeostasis, which may beneficially affect the angiogenic function of endothelial cells under hypoxia in vitro and in vivo

    Oral pyruvate prevents high-intensity interval exercise-induced metabolic acidosis in rats by promoting lactate dehydrogenase reaction

    Get PDF
    IntroductionThere is no denying the clinical benefits of exogenous pyruvate in the treatment of pathological metabolic acidosis. However, whether it can prevent exercise physiological metabolic acidosis, delay the occurrence of exercise fatigue, and improve the beneficial effects of exercise and its internal mechanism remain unclear.MethodsWe randomly divided 24 male SD rats into 3 groups: one group was a control without exercise (CC, n = 8), and the other two groups were supplemented with 616 mg/kg/day pyruvate (EP, n = 8) or distilled water of equal volume (EC, n = 8). These groups completed acute high-intensity interval exercise (HIIE) after 7 days of supplementation. The acid metabolism variables were measured immediately after exercise including blood pH (pHe), base excess (BE), HCO3−, blood lactic acid and skeletal muscle pH (pHi). The redox state was determined by measuring the oxidized coenzyme I/reduced coenzyme I (nicotinamide adenine dinucleotide [NAD+]/reduced NAD+ [NADH]) ratio and lactate/pyruvate (L/P) ratio. In addition, the activities of lactate dehydrogenase A (LDHA), hexokinase (HK), phosphofructokinase (PFK) and pyruvate kinase (PK) were determined by ELISA.ResultsPyruvate supplementation significantly reversed the decrease of pHe, BE, HCO3− and pHi values after HIIE (p < 0.001), while significantly increased the activities of LDHA (p = 0.048), HK (p = 0.006), and PFK (p = 0.047). Compared with the CC, the NAD+/NADH (p = 0.008) ratio and the activities of LDHA (p = 0.002), HK (p < 0.001), PFK (p < 0.001), and PK (p = 0.006) were significantly improved in EP group.DiscussionThis study provides compelling evidence that oral pyruvate attenuates HIIE-induced intracellular and extracellular acidification, possibly due to increased activity of LDHA, which promotes the absorption of H+ in the LDH reaction. The beneficial effects of improving the redox state and glycolysis rate were also shown. Our results suggest that pyruvate can be used as an oral nutritional supplement to buffer HIIE induced metabolic acidosis

    Low-mass dark matter search results from full exposure of PandaX-I experiment

    Full text link
    We report the results of a weakly-interacting massive particle (WIMP) dark matter search using the full 80.1\;live-day exposure of the first stage of the PandaX experiment (PandaX-I) located in the China Jin-Ping Underground Laboratory. The PandaX-I detector has been optimized for detecting low-mass WIMPs, achieving a photon detection efficiency of 9.6\%. With a fiducial liquid xenon target mass of 54.0\,kg, no significant excess event were found above the expected background. A profile likelihood analysis confirms our earlier finding that the PandaX-I data disfavor all positive low-mass WIMP signals reported in the literature under standard assumptions. A stringent bound on the low mass WIMP is set at WIMP mass below 10\,GeV/c2^2, demonstrating that liquid xenon detectors can be competitive for low-mass WIMP searches.Comment: v3 as accepted by PRD. Minor update in the text in response to referee comments. Separating Fig. 11(a) and (b) into Fig. 11 and Fig. 12. Legend tweak in Fig. 9(b) and 9(c) as suggested by referee, as well as a missing legend for CRESST-II legend in Fig. 12 (now Fig. 13). Same version as submitted to PR
    • 

    corecore