Changes of health-related quality of life within the 1st year after stroke – results from a prospective stroke cohort study

Introduction: As prospective data on long-term patient-reported outcome measures (PROMs) to assess Health related Quality of Life (HRQoL) after stroke are still scarce, this study examined the long-term course of PROMs and investigated influential factors such as recanalization therapies. Materials and Methods: A total of 945 (mean age 69 years; 56% male) stroke patients were enrolled with a personal interview and chart review performed at index event. One hundred forty (15%) patients received thrombolysis (IVT) and 53 (5%) patients received endovascular therapy (ET) or both treatments as bridging therapy (BT). After 3 and 12 months, a follow-up was conducted using a postal questionnaire including subjective quality of life EQ-5D-5L (European Quality of Life 5 Dimensions). At all time-points, Modified Rankin Scale (mRS) was additionally used to quantify functional stroke severity. Differences between therapy groups were identified using post-hoc-tests. Linear and logistic regression analyses were used to identify predictors of outcomes. Results: Recanalization therapies were associated with significant improvements of NIHSS (National Institutes of Health Stroke Scale [regression coefficient IVT 1.21 (p = 0.01) and ET/BT 7.6; p = 0.001] and mRS (modified Rankin Scale) [regression coefficient IVT 0.83; p = 0.001 and ET/BT 2.0; p = 0.001] between admission and discharge compared to patients with stroke unit therapy only, with a trend toward improvement of EQ-5D after 12 months [regression coefficient 4.67 (p = 0.17)] with IVT. HRQoL was considerably impaired by stroke and increased steadily in 3- and 12-months follow-up in patients with (mean EQ-5D from 56 to 68) and without recanalization therapy (mean EQ-5D from 62 to 68). In severe strokes a major and significant improvement was only detected during period of 3 to 12 months (p = 0.03 in patients with and p = 0.005 in patients without recanalization therapy). Conclusions: Despite significant and continuous improvements after stroke the HRQoL after 12 months remained below the age-matched general population, but was still unexpectedly high in view of the accumulation of permanent disabilities in up to 30% of the patients. Especially in severe strokes, it is important to evaluate HRQoL beyond a 3-months follow-up as improvements became significant only between 3 months and 1 year

Hydrology controls the carbon mass balance of a mountain lake in the eastern European Alps

Lakes and streams in mountain regions are important contributors to carbon (C) fluxes. However, detailed carbon balances of the stream‐lake continuum are rare. Combining eddy covariance (EC) measurements of lake‐atmosphere net ecosystem CO2 exchange with measurements of fluvial C fluxes (dissolved organic C, DOC; particulate organic C, POC; dissolved inorganic C, DIC), and in‐lake sedimentation, we here present a detailed annual C balance of an oligotrophic clearwater lake in the eastern European Alps. The C flux into the lake was 1522 Mg C year−1 by DIC (93%), DOC (6%), and POC (0.7%). The largest C losses were fluvial exports (1595 Mg C year−1) of DIC (93%), DOC (6%), and POC (0.8%), while sedimentation accounted for 7.3 Mg C year−1. The residual of all fluvial and sedimentation fluxes revealed the lake as a net sink of atmospheric CO2 of 77 Mg C year−1. The EC measurement confirmed a small positive or negative contribution of atmospheric exchange to the lake C balance. In‐lake transfer among C pools was only significant for the flux from DIC to POC (8.4 Mg C year−1), which, following our model, is the transfer through primary production in summer. Fluvial DOC and DIC fluxes were controlled by discharge; POC retention and sedimentation depended on the meteorological season and in‐lake residence time. Following our findings, we conclude that hydrology acted as the most important control for the C balance of this clearwater mountain lake by controlling inflow, outflow, and sedimentation fluxes

Climate-induced hydrological variation controls the transformation of dissolved organic matter in a subalpine lake

Lakes are an inherent component of the global carbon cycle. They receive dissolved organic matter (DOM) from the catchment, which is stored, transformed and respired, or delivered downstream. In this study, we show that a subalpine lake shifts its role from DOM “transporter” to “transformer” depending on season and climate. We monitored dissolved organic carbon (DOC) concentration and DOM optical properties at the inlet and outlet of subalpine Lake Lunz (Austria) at high frequency during two contrasting years: an extreme drought in 2015, and regular precipitation regime in 2016. During both years, the DOC mass balance revealed that inflowing and outflowing DOC loads were nearly balanced (16.57% and 11.70% DOC production in 2015 and 2016, respectively). However, DOM optical properties revealed an in-lake turnover of DOM compounds, so that the terrestrial and aromatic signature of inflowing DOM was modified into autochthonous, protein-like DOM. The magnitude of this transformation varied seasonally, being maximal in summer and minimal in winter, presumably following periods of high and low primary production and photodegradation. Inter-annually, we found that drought further increased DOM transformation during summer by extending the lake water residence time. Finally, our results demonstrate a rapid response of DOM dynamics to hydrological and meteorological changes at both seasonal and inter-annual scales, suggesting that carbon cycling in clear-water mountain lakes may be highly sensitive to hydrological variation

Zerstörungsfreie archäologische Prospektion des römischen Carnuntum : erste Ergebnisse des Forschungsprojekts „ArchPro Carnuntum“

Over the course of four years (2012–2015) the Ludwig Boltzmann Institute for Archaeological Prospection and Virtual Archeology (LBI ArchPro), in collaboration with the Central Institute for Meteorology and Geodynamics (ZAMG) and on behalf of the provincial government of Lower Austria, has conducted the comprehensive, non-invasive archaeological prospection project entitled “ArchPro Carnuntum”. The purpose of this project has been to generate a basis for future archaeological research and the sustainable spatial planning and cultural heritage management in the area. By combining new information on buried archaeology using different aerial and ground-based archaeological prospection methods and a thorough archaeological interpretation of the combined data within the framework of a GIS environment, it was possible to document Carnuntum’s archaeological heritage, which is threatened by a dramatic increase in erosion and destruction through ploughing, infrastructure development and looting by treasure hunters. In total, an area covering eight square kilometres was explored at very high sampling resolution using magnetic prospection methods, while 2.5 square kilometres were mapped with ultra-high resolution ground-penetrating radar measurements. The results of the project and the spatio-temporal analysis and interpretation of the prospection data are presented here as a preliminary report