379 research outputs found

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    Program for the 40th annual Fay B. Kaigler Children\u27s Book Festiva

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    Program for the 44th Annual Fay B. Kaigler Children\u27s Book Festiva

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    Program for the 41st annual Fay B. Kaigler Children\u27s Book Festiva

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    Program for the 43rd annual Fay B. Kaigler Children\u27s Book Festiva

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    Program for the 40th annual Fay B. Kaigler Children\u27s Book Festiva

    ComputerĂą Guided Immediate Implant Placement and Predigitally Designed Immediate Provisionalization

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    Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142440/1/cap10007_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142440/2/cap10007.pd

    Comparative analysis of dental implant treatment outcomes following mandibular reconstruction with double‐barrel fibula bone grafting or vertical distraction osteogenesis fibula: a retrospective study

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    PurposeThe purpose of this study was twofold: (i) to compare vertical bone height (VBH) after tumor resection through grafting with either a double‐barrel fibula (DBF) technique or vertical distraction osteogenesis of the fibula (VDOF); (ii) to compare the performance of loaded dental implants following either DBF or VDOF with special focus on implant survival, implant success, and bone resorption.Materials and methodsThis retrospective clinical study involved 19 patients who underwent implant placement following DBF (group A, n = 9) or VDOF (group B, n = 10) for mandibular reconstruction from March 2006 to May 2008. Clinical and radiographic assessments, including VBH, modified Plaque Index (mPI), modified Sulcus Bleeding Index (mSBI), and marginal bone level (MBL), were taken for both groups after delivery of the final prostheses and annually thereafter.ResultsNine patients underwent DBF with 24 implants placed and 10 patients underwent VDOF with 27 implants placed for mandibular reconstruction after tumor resection. Overall, all DBF and VDOF procedures were successful for group A and group B. VBH for group A and group B were 20 and 17 mm. There was no statistically significant difference of mSBI scores between group A and group B in the 3‐year follow‐up (P = 0.40). In four cases with eight implants of group A and two cases with three implants of group B, granulomatous soft tissue grew. There was no statistically significant differences of MBL between group A and group B in the 3‐year follow‐up (p = 0.736). The cumulative survival and success rates of implants for group A were 100% and 87.5%, and for group B were 100% and 85.2% in 3‐year follow‐up, respectively.ConclusionsOn the basis of the study of 19 patients who received a total of 51 implants, reconstruction of the mandible with DBF flap or VDOF flap, combined with dental implant therapy, was considered a predictable option. Compared with implants placed in VDOF bone, implants placed in DBF bone had a relative higher incidence of associated gingival inflammation. The DBF bone seems more resistant to peri‐implant resorption processes than VDOF bone during functional loading.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/110599/1/clr12300.pd

    Role of Vascular Endothelial Growth Factor in Bone Marrow Stromal Cell Modulation of Endothelial Cells

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    One of the fundamental principles that underlies tissue-engineering strategies using cell transplantation is that a newly formed tissue must acquire and maintain sufficient vascularization in order to support its growth. Enhancing angiogenesis through delivery of growth factors is one approach to establishing a vascular network to these tissues. In this study, we tested the potential of bone marrow stromal cells (BMSCs) to modulate the growth and differentiation activities of blood vessel precursors, endothelial cells (ECs), by their secretion of soluble angiogenic factors. The growth and differentiation of cultured ECs were enhanced in response to exposure to BMSC conditioned medium (CM). Enzyme-linked immunosorbent assays demonstrated that both mouse and human BMSCs secreted significant quantities of vascular endothelial growth factor (VEGF) (2.4-3.1 ng/106 cells per day). Furthermore, eliminating the activity of BMSC-secreted VEGF with blocking antibodies completely blocked the CM effects on cultured ECs. These data demonstrate that human BMSCs secrete sufficient quantities of VEGF to enhance survival and differentiation of endothelial cells in vitro, and suggest they may be capable of directly orchestrating angiogenesis in vivo.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63256/1/107632703762687573.pd
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