3,149 research outputs found
Ovarian cancer classification based on dimensionality reduction for SELDI-TOF data
<p>Abstract</p> <p>Background</p> <p>Recent advances in proteomics technologies such as SELDI-TOF mass spectrometry has shown promise in the detection of early stage cancers. However, dimensionality reduction and classification are considerable challenges in statistical machine learning. We therefore propose a novel approach for dimensionality reduction and tested it using published high-resolution SELDI-TOF data for ovarian cancer.</p> <p>Results</p> <p>We propose a method based on statistical moments to reduce feature dimensions. After refining and <it>t</it>-testing, SELDI-TOF data are divided into several intervals. Four statistical moments (mean, variance, skewness and kurtosis) are calculated for each interval and are used as representative variables. The high dimensionality of the data can thus be rapidly reduced. To improve efficiency and classification performance, the data are further used in kernel PLS models. The method achieved average sensitivity of 0.9950, specificity of 0.9916, accuracy of 0.9935 and a correlation coefficient of 0.9869 for 100 five-fold cross validations. Furthermore, only one control was misclassified in leave-one-out cross validation.</p> <p>Conclusion</p> <p>The proposed method is suitable for analyzing high-throughput proteomics data.</p
Tungsten disulfide-gold nanohole hybrid metasurfaces for nonlinear metalens in the visible region
Recently, nonlinear hybrid metasurface comes into an attractive new concept
in the research of nanophotonics and nanotechnology. It is composed of
semiconductors with an intrinsically large nonlinear susceptibility and
traditional plasmonic metasurfaces, offering opportunities for efficiently
generating and manipulating nonlinear optical responses. A high second-harmonic
generation (SHG) conversion efficiency has been demonstrated in the
mid-infrared region by using multi-quantum-well (MQW) based plasmonic
metasurfaces. However, it has yet to be demonstrated in the visible region.
Here we present a new type of nonlinear hybrid metasurfaces for the visible
region, which consists of a single layer of tungsten disulfide (WS2) and a
phased gold nanohole array. The results indicate that a large SHG
susceptibility of ~0.1 nm/V at 810 nm is achieved, which is 2~3 orders of
magnitude larger than that of typical plasmonic metasurfaces. Nonlinear
metalenses with the focal lengths of 30 {\mu}m, 50 {\mu}m and 100 {\mu}m are
demonstrated experimentally, providing a direct evidence for both generating
and manipulating SH signals based on the nonlinear hybrid metasurfaces. It
shows great potential applications in designing of integrated, ultra-thin,
compacted and efficient nonlinear optical devices, such as frequency
converters, nonlinear holography and generation of nonlinear optical vortex
beam
Terminal Deletion of Chromosome 6q
Terminal deletions of chromosome 6q are rare. Clinical features associated with 6q terminal deletion syndrome include psychomotor retardation, seizures, hypotonia, short neck, and facial abnormalities, as well as various case-specific anomalies. Here, we describe a girl with 6q terminal deletion syndrome and unusually short stature. Features of previously described patients are also summarized
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