第665回 千葉医学会例会・第18回 佐藤外科例会 6.

Estimates of Diptychus maculatus divergence times obtained with BEASTv1.8.0. (DOCX 86 kb

Additional file 3: Table S2. of Genomic signature of highland adaptation in fish: a case study in Tibetan Schizothoracinae species

Annotation of assembled unigenes in G. p. ganzihonensis transcriptome. (XLS 41915 kb

Additional file 8: Table S5. of Genomic signature of highland adaptation in fish: a case study in Tibetan Schizothoracinae species

Positively selected genes (PSGs) identified in G. p. ganzihonensis. (XLS 64 kb

Additional file 6: Table S3. of Genomic signature of highland adaptation in fish: a case study in Tibetan Schizothoracinae species

Species distribution is calculated as a percentage of the total homologous sequences. (XLS 27 kb

Additional file 1: Table S1. of Genomic signature of highland adaptation in fish: a case study in Tibetan Schizothoracinae species

Summary of sequencing, assembly and analysis of G. p. ganzihonensis transcriptome. (DOC 36 kb

Additional file 7: Table S4. of Genomic signature of highland adaptation in fish: a case study in Tibetan Schizothoracinae species

GO categories showing accelerated evolutionary rates within G. p. ganzihonensis and Danio rerio. (XLS 104 kb

Additional file 5: Figure S3. of Genomic signature of highland adaptation in fish: a case study in Tibetan Schizothoracinae species

GO classification of assembled unigenes in G. p. ganzihonensis transcriptome. (PDF 21 kb

Additional file 4: Figure S2. of Genomic signature of highland adaptation in fish: a case study in Tibetan Schizothoracinae species

COG classification of assembled unigenes in G. p. ganzihonensis transcriptome. (PDF 22 kb

TRIM26 Negatively Regulates Interferon-β Production and Antiviral Response through Polyubiquitination and Degradation of Nuclear IRF3

<div><p>Virus infection leads to the activation of transcription factor IRF3 and subsequent production of type I inteferons, which induce the transcription of various antiviral genes called interferon stimulated genes (ISGs) to eliminate viral infection. IRF3 activation requires phosphorylation, dimerization and nuclear translocation. However, the mechanisms for the termination of IRF3 activation in nucleus are elusive. Here we report the identification of TRIM26 to negatively regulate IFN-β production and antiviral response by targeting nuclear IRF3. TRIM26 bound to IRF3 and promoted its K48-linked polyubiquitination and degradation in nucleus. TRIM26 degraded WT IRF3 and the constitutive active mutant IRF3 5D, but not the phosphorylation deficient mutant IRF3 5A. Furthermore, IRF3 mutant in the Nuclear Localization Signal (NLS), which could not move into nucleus, was not degraded by TRIM26. Importantly, virus infection promoted TRIM26 nuclear translocation, which was required for IRF3 degradation. As a consequence, TRIM26 attenuated IFN-β promoter activation and IFN-β production downstream of TLR3/4, RLR and DNA sensing pathways. TRIM26 transgenic mice showed much less IRF3 activation and IFN-β production, while increased virus replication. Our findings delineate a novel mechanism for the termination of IRF3 activation in nucleus through TRIM26-mediated IRF3 ubiquitination and degradation.</p></div

Amorphous/Nanocrystalline, Lightweight, Wave-Transparent Boron Nitride Nanobelt Aerogel for Thermal Insulation

At present, the new generation of aircraft is developing in the direction of high speed, long endurance, high mobility, and repeatability. Some studies have shown that the surface temperature of the radome can reach even 1800 °C as the flight speed of the aircraft increases. However, the antenna inside the radome cannot serve at this temperature. Consequently, a thermal insulation system with electromagnetic wave-transparent ability and high-temperature resistance is urgently needed to protect the antenna from working normally. An aerogel material is known as “solid smoke,” with the lowest density currently. Because of its high porosity (>90%) and the characteristics of nanopore size, its application in the field of thermal insulation always draws the attention of researchers. In this work, a novel amorphous/nanocrystalline boron nitride (BN) nanobelt aerogel was synthesized successfully. The BN aerogel shows lightweight (18 mg/cm3), good thermal stability (1400 °C under an inert atmosphere and 750 °C under an air atmosphere), wideband wave-transparent performance (dielectric constant of 1.03 and dielectric loss of 0.016 at 4–18 GHz), and thermal insulation property (43 mW/(m·K) at room temperature and 73 mW/(m·K) at 600 °C). The BN aerogel is a suitable candidate as an electromagnetic wave-transparent thermal insulator and fire-resistant material. What is more, the structural stability of the BN aerogel is good (Young’s modulus remains basically constant during the fatigue tests), and the energy loss coefficient (∼0.56) is high; it also has the potential to be a mechanical energy dissipative material. The study on the amorphous/nanocrystalline BN nanobelt aerogel provides a new idea for structure design and performance optimization of a high-temperature electromagnetic functional insulation material